Search results for "Audit"
showing 10 items of 1421 documents
Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products
2021
Funding Information: We would like to thank A. Löfhjelm and L. Saari for excellent technical assistance. This work was supported by a Sigrid Jusélius Foundation grant to H.K. and the Academy of Finland funding (321809) to T.S. We would also like to thank the Erkko Foundation and Nordforsk Nordic center of Excellency NordAqua (project number #82845) and University of Helsinki’s Doctoral Programme in Microbiology and Biotechnology funding to M.N.A. D.O.A. was supported by a postdoctoral research fellowship from the São Paulo Research Foundation (FAPESP #2018/01563-2). We thank Biocenter Kuopio for the use of their facilities for molecular modeling and MD simulations. We thank the DNA Sequenci…
Immuno-electron microscopic localization of the alpha(1) and beta(1)-subunits of soluble guanylyl cyclase in the guinea pig organ of corti.
2000
Guanylyl cyclases (GC) catalyze the formation of the intracellular signal molecule cyclic GMP from GTP. For some years it has been known that the heme-containing soluble guanylyl cyclase (sGC) is stimulated by NO and NO-containing compounds. The sGC enzyme consists of two subunits (alpha(1) and beta(1)). In the present study, the alpha(1) and beta(1)-subunits were identified in the guinea pig cochlea at the electron microscopic level using a post-embedding immuno-labeling procedure. Ultrathin sections of LR White embedded specimens were incubated with various concentrations of two rabbit polyclonal antibodies to the alpha(1)- and beta(1)-subunit, respectively. The immunoreactivity was visua…
Resectability, conversion, metastasectomy and outcome according to RAS and BRAF status for metastatic colorectal cancer in the prospective RAXO study
2022
Abstract Background Outcomes after metastasectomy for metastatic colorectal cancer (mCRC) vary with RAS and BRAF mutational status, but their effects on resectability and conversion rates have not been extensively studied. Methods This substudy of the prospective RAXO trial included 906 patients recruited between 2011 and 2018. We evaluated repeated centralised resectability assessment, conversion/resection rates and overall survival (OS), according to RAS and BRAF status. Results Patients included 289 with RAS and BRAF wild-type (RAS and BRAFwt), 529 with RAS mutated (RASmt) and 88 with BRAF mutated (BRAFmt) mCRC. Metastatic prevalence varied between the RAS and BRAFwt/RASmt/BRAFmt groups,…
Using an integrated social cognition model to predict COVID‐19 preventive behaviours
2020
ObjectivesRates of novel coronavirus disease 2019 (COVID-19) infections have rapidly increased worldwide and reached pandemic proportions. A suite of preventive behaviours have been recommended to minimize risk of COVID-19 infection in the general population. The present study utilized an integrated social cognition model to explain COVID-19 preventive behaviours in a sample from the Iranian general population.DesignThe study adopted a three-wave prospective correlational design.MethodsMembers of the general public (N = 1,718, Mage = 33.34, SD = 15.77, male = 796, female = 922) agreed to participate in the study. Participants completed self-report measures of demographic characteristics, i…
Pure-Tone Thresholds, Speech Understanding, and Their Correlates in Samples of Men of Different Ages1
1986
Pure-tone thresholds and speech understanding were studied in three samples of men of different ages (31-35, 51-55 and 71-75 years). The air-conducted pure-tone thresholds were measured at 125-8,000 Hz and speech understanding by the help of interrupted and masked speech tests. The audiological measures were related to measures of other sensory functions, psychomotor speed, cognitive functions, psychic well-being, occupational and educational background and health. The results indicated a clear decrement in all audiological measures when proceeding from younger to older age groups. The results of the speech-understanding tests correlated significantly with the pure-tone thresholds both at 4…
Nordic Comparison of 75-Year-Olds - Sensory and Psychomotor Functions
1993
Sensory and psychomotor functions were studied among 75-year-old men and women in three Nordic localities (Glostrup in Denmark, Gothenburg in Sweden, and Jyvaskyla in Finland) as part of a comparative study on functional capacity and health. Random samples were drawn from the population registers in Glostrup (n=550) and Gothenburg (n=450), whereas in Jyvaskyla all 75-year-old residents (n=388) were invited to participate in the study. Participation rates varied from 66.8% in Gothenburg to 79.1% in Jyvaskyla. Sensory functions studied included hearing (pure-tone thresholds at 125-8000 Hz), vision (visual acuity, refraction, intraocular pressure), balance (postural sway), and tactual sensitiv…
Mediators of change in online acceptance and commitment therapy for psychological symptoms of parents of children with chronic conditions : An invest…
2020
Highlights: Parents of children with chronic conditions can benefit from an ACT web intervention. Cognitive defusion and acting with awareness mediated effects on psychological symptoms. General psychological flexibility did not mediate effects on outcomes. Improving mindfulness skills aid in optimizing treatment effects in online interventions. peerReviewed
Industry specialization and audit fees: a meta-analytic approach
2015
Purpose The purpose of this paper is to provide a comprehensive review of the literature that links auditor’s industry specialization (AIS) and audit fees (AFs) in order to clarify the puzzle of published results and provide overall conclusions that would help in future research. Design/methodology/approach To achieve this goal, the authors applied meta-analysis techniques in order to summarize, quantify and evaluate the published data related to the association between AIS and AF. Findings The meta-results are more robust when the proxy for AIS is the audit firm’s market share above 20 percent or the audit firm is jointly the national and city leader. For US-based studies, results are hom…
Audiological Investigation of Otitis Media in Children with Atopy
2011
Otitis media (OM) describes an inflammatory process within the middle ear space that is generally associated with accumulation of fluid and that may lead to hearing loss, learning difficulties, and delays in language development. The pathogenesis of OM is multifactorial, involving the adaptive and native immune system, eustachian tube dysfunction, viral and bacterial load, and genetic and environmental factors. The involvement of IgE-mediated allergic reactions in the pathogenesis of OM has been suggested by clinical observations of a high prevalence of OM among patients with allergies. Evidence from studies involving tympanometric measurements, audiometric measurements, and otoscopic exami…
Assessment of the worldwide burden of critical illness: The Intensive Care Over Nations (ICON) audit
2014
Item does not contain fulltext BACKGROUND: Global epidemiological data regarding outcomes for patients in intensive care units (ICUs) are scarce, but are important in understanding the worldwide burden of critical illness. We, therefore, did an international audit of ICU patients worldwide and assessed variations between hospitals and countries in terms of ICU mortality. METHODS: 730 participating centres in 84 countries prospectively collected data on all adult (>16 years) patients admitted to their ICU between May 8 and May 18, 2012, except those admitted for fewer than 24 h for routine postoperative monitoring. Participation was voluntary. Data were collected daily for a maximum of 28 da…