Search results for "Aurora"
showing 10 items of 41 documents
Uzskaites sistēma lopkopībai
2018
Jāņa Luca kvalifikācijas darbā “Lopkopības uzskaites sistēma” ir izstrādāta lietotne Aurora. Lietotne ir paredzēta privātpersonām un uzņēmumiem, kas nodarbojas ar lopkopību un paša sistēma ir balstīta uz valsts lauksaimniecības datu centru un tā uzlabošanu. Lietotnes mērķis – atvieglot datu glabāšanu lopkopjiem un ieviest funkcionalitātes, ko nepiedāvā valsts lauksaimniecības datu centrs. Aurora lietotnē ir trīs galvenās datu kategorijas – dzīvnieki, ganāmpulki un novietnes. Katrai no šīm kategorijām ir datu izveide, datu dzēšana, datu rediģēšana un datu saraksts jeb tabula. Papildus šīm kategorijām ir datu meklēšanas filtri, lai atvieglotu meklēšanu liela apjoma datu daudzumam. Lietotne ir…
Aurora kinases in ovarian cancer
2020
Aurora kinases (AURK) are key regulators of the mitotic spindle formation. AURK is frequently overexpressed in ovarian cancer and this overexpression has been frequently associated with prognosis in these tumours. Interestingly, AURK have been shown to interact with DNA repair mechanisms and other cell cycle regulators. These functions have brought light to Aurora family as a potential target for anticancer therapy. In the last years, two clinical trials with different AURK inhibitors have shown activity in epithelial and clear-cell ovarian cancer. Although there is a lack of predictive factors of AURK inhibition activity, recent trials have identified some candidates. This review will focu…
Prognostic significance of interferon regulating factor 4 (IRF4) in node-negative breast cancer.
2014
620 Background: The transcription factor IRF4 (interferon regulating factor 4) regulates immunoglobulin class switch recombination as well as plasma cell differentiation. We examined the prognostic significance of IRF4 mRNA expression in node-negative breast cancer. Methods: Microarray based gene-expression data for IRF4 (204562_at) were analysed in four previously published cohorts (Mainz, Rotterdam, Transbig, Yu) of node-negative breast cancer patients not treated with adjuvant therapy (n=824). A meta-analysis of previously published cohorts was performed using a random effects model. Prognostic significance of IRF4 on metastasis-free survival (MFS) was examined in the whole cohort and in…
Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase
2011
Abstract The mitotic kinase Aurora A is an important therapeutic target for cancer therapy. This study evaluated new mechanism-based pharmacodynamic biomarkers in cancer patients in two phase I studies of MLN8054, a small-molecule inhibitor of Aurora A kinase. Patients with advanced solid tumors received MLN8054 orally for 7 consecutive days in escalating dose cohorts, with skin and tumor biopsies obtained before and after dosing. Skin biopsies were evaluated for increased mitotic cells within the basal epithelium. Tumor biopsies were assessed for accumulation of mitotic cells within proliferative tumor regions. Several patients in the highest dose cohorts showed marked increases in the ski…
Aurora-A Transcriptional Silencing and Vincristine Treatment Show a Synergistic Effect in Human Tumor Cells
2008
Aurora-A is a centrosome-associated serine/threonine kinase that is overexpressed in multiple types of human tumors. Primarily, Aurora-A functions in centrosome maturation and mitotic spindle assembly. Overexpression of Aurora-A induces centrosome amplification and G 2 /M cell cycle progression. Recently, it was observed that overexpression of Aurora-A renders cells resistant to cisplatin (CDDP)-, etoposide-, and paclitaxel-induced apoptosis.Our results indicate that already in initial stages of cancer progression Aurora-A overexpression could have a major role in inducing supernumerary centrosomes and aneuploidy, as shown by immunohistochemistry on tissue sections from various stages of hu…
Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
2012
Abstract Purpose: The limited supply of oxygen and nutrients is thought to result in rigorous selection of cells that will eventually form the tumor. Experimental Design: Nupr1 expression pattern was analyzed in human tissue microarray (TMA) and correlated with survival time of the patient. Microarray analysis was conducted on MiaPaCa2 cells subjected to metabolic stress in Nupr1-silenced conditions. DNA repair and cell cycle–associated gene expression was confirmed by real-time quantitative PCR (qRT-PCR). Nupr1 and AURKA protective role were analyzed using RNA interference (RNAi) silencing or overexpression. DNA damage and autophagy were analyzed by Western blot analysis and immunofluoresc…
HIF-1 is involved in the negative regulation of AURKA expression in breast cancer cell lines under hypoxic conditions
2013
Numerous microarray-based gene expression studies performed on several types of solid tumors revealed significant changes in key genes involved in progression and regulation of the cell cycle, including AURKA that is known to be overexpressed in many types of human malignancies. Tumor hypoxia is associated with poor prognosis in several cancer types, including breast cancer (BC). Since hypoxia is a condition that influences the expression of many genes involved in tumorigenesis, proliferation, and cell cycle regulation, we performed a microarray-based gene expression analysis in order to identify differentially expressed genes in BC cell lines exposed to hypoxia. This analysis showed that h…
AURKA (aurora kinase A)
2011
Review on AURKA (aurora kinase A), with data on DNA, on the protein encoded, and where the gene is implicated.
Gozos en alabanza de la mas esclarecida Aurora del Sol de Justicia la Virgen Maria : Venerada su hermosa Imagen en la Villa de Alcora
El full orlat Grav. xil. enmarcat de "N. S. del Rosario", situat entre les paraules del tít. i flanquejat per ornaments florals Text del goig a tres col.
Gozos a la Divina Aurora, venerada en la villa de Alcira
1849
El full orlat Grav. enmarcat de la Mare de Déu, flanquejat per ornaments florals Text del goig a tres col. separades per filets