Search results for "Aurora"
showing 10 items of 41 documents
18P In vitro analysis of the combination of APR-246 and carboplatin in triple negative breast cancer (TNBC) and high grade serous ovarian cancer (HGS…
2021
DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells.
2013
Recent studies have highlighted an apparently paradoxical link between self-renewal and senescence triggered by DNA damage in certain cell types. In addition, the finding that TP53 can suppress senescence has caused a re-evaluation of its functional role in regulating these outcomes. To investigate these phenomena and their relationship to pluripotency and senescence, we examined the response of the TP53-competent embryonal carcinoma (EC) cell line PA-1 to etoposide-induced DNA damage. Nuclear POU5F1/OCT4A and P21CIP1 were upregulated in the same cells following etoposide-induced G 2M arrest. However, while accumulating in the karyosol, the amount of OCT4A was reduced in the chromatin fract…
HIF-1a induces downregulated expression of Aurora A in breast cancer cell lines
2012
Background: Aurora A (AURKA) is an oncogenic serine/treonine kinase that play a critical role during mitosis, governing the correct distribution of genetic material to the daughter cells. AURKA is overexpressed in many types of human tumors including breast cancer and its deregulated expression, inducing alteration of mitotic spindle, chromosomal segregation and aneuploidy can lead to malignant transformation of cells. Aims: Since hypoxia is a typical tumoral condition which influences the expression of various proteins involved in proliferation and cell cycle progression, aim of our study was to obtain new insights into AURKA regulation in breast cancer cell lines cultured under normoxic a…
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells
2013
In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from an epithelial to a highly invasive mesenchymal phenotype in estrogen receptor α-positive (ERα(+)) breast cancer cells. The transition from an epithelial- to a mesenchymal-like phenotype was characterized by reduced expression of ERα, HER-2/Neu overexpression and loss of CD24 surface receptor (CD24(-/low)). Importantly, expression of key epithelial-to-mesenchymal transition (EMT) markers and upregulation of the stemness gene SOX2 was linked to acquisition of stem cell-like properties such as the ab…
RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation
2009
BACKGROUND: Changes in chromosome number or structure as well as supernumerary centrosomes and multipolar mitoses are commonly observed in human tumors. Thus, centrosome amplification and mitotic checkpoint dysfunctions are believed possible causes of chromosomal instability. The Retinoblastoma tumor suppressor (RB) participates in the regulation of synchrony between DNA synthesis and centrosome duplication and it is involved in transcription regulation of some mitotic genes. Primary human fibroblasts were transfected transiently with short interfering RNA (siRNA) specific for human pRb to investigate the effects of pRb acute loss on chromosomal stability. RESULTS: Acutely pRb-depleted fibr…
Diálogos con la pintura de Pinazo
2017
El oro : símbolo de lo transcendente en la pintura gótica. Su capacidad como elemento transformador, espiritual y plástico
2011
Posada en valor de la pintura mural gòtica lineal a territori valencià. Un cas a descobrir: el Palau-Castell de Llutxent
2016
Entre air et terre: les éléments dans Aurora Leigh d'Elizabeth Barrett Browning
2010
Surprinsingly enough, despite the fact that it is strongly associated with femininity, Elizabeth Barrett Browning has no use for water as an element in her narrative of Aurora Leigh's progress as a poet in the eponymous poem. Fire is only used in its usual purifying function. But she does construct a complex architecture from the elements of aire and earth. She starts with the generally accepted duality of earth, both nurturing and a symbol of death. She multiplies the associations with air: angels and squirrels, wind and mountains, to cite only a few. She then examines and redefines the relationships between these two elements in liofe and in poetry and finally reaches a mystical union anc…
The Intimations of "Aurora Leigh" in Elizabeth Barrett's Love Letters
2008
The last letters in the courtship of Elizabeth Barrett and Robert Browning deal of course with all the practical aspects of what was to be the run away match of the century. But they also reveal feelings, attitudes and modes of writing that will grow and become the trademark of the mature Elizabeth Barrett Browning's poetry, in particular "Aurora Leigh". One finds in them an interest in ordinary people's lives, a sense of humour, a resistance to masculine authority and an assertion of equality between the genders that will all be at the heart of her great poem.