Search results for "Autism spectrum"
showing 10 items of 239 documents
Zinc Finger Proteins in Neuro-Related Diseases Progression
2021
Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, zinc finger proteins can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many zinc finger proteins are associated with neurological diseases. The purpose of this review is to summarize the types and roles of zinc finger proteins in neuropsychiatric disorders. We will describe the structure and classification of zinc finger proteins, then focus on the pathophysiological role of zinc finge…
Effect of a Service-Learning Program on the Active Lifestyle of Children with Autism Spectrum Disorder: A Pilot Study
2020
Background: active lifestyles and Physical Activity (PA) are closely related to health. Healthy habits such as being physically active should be consolidated during childhood. Children with Autism Spectrum Disorders (ASD) present fewer opportunities to be involved in PA. For this reason, we conducted a Service-Learning (SL) program to enhance the possibility of participating ASD children enjoying PA sessions. The aim of this study was to analyze and describe the evolution in terms of the frequency and intensity of PA performed by ASD children who participated in the SL program. Methods: we used a quasi-experimental design. The sample was formed by 26 children with ASD (Experimental group: n…
Autisma iezīmes, agresivitāte un vecāku – bērnu mijiedarbība bērniem vecumā no 22 līdz 30 mēnešiem
2018
Pētījuma ietvaros tika apzinātas sakarības starp autiskā spektra iezīmēm, agresivitāti un audzināšanas pieejām vecāku-bērnu mijiedarbībā bērniem 22-30 mēnešu vecumā, un noskaidrots, vai pastāv statistiski nozīmīgas atšķirības agresivitātes rādījumos bērniem ar un bez autiskā spektra traucējumu iezīmēm. Pētāmo izlase: 115 bērni vecumā no 22 līdz 30 mēnešiem, apakšizlasē 18 bērni. Tika izmantota bērna uzvedības novērtējuma anketa (Achenbach & Rescorla, 2000), adaptēta un pielietota „AS Detect” aptauja (Barbaro, 2016), Ģentes audzināšanas aptauja - vecāku versija (Van Leeuwen et.al., 2004), vecāku - bērnu mijiedarbības video novērojumi (Eyberg, 2002). Pētījuma rezultāti norāda uz statistiski n…
For a real job? : Views on the teaching of competence in working life by students with Autism Spectrum Disorder (ASD)
2021
In this study, twelve young students on the autism spectrum were interviewed on preparation for working life, employment guidance, the challenges and strengths of the autism spectrum, and suitable teaching methods. Interviews were supported by a structured and illustrated questionnaire. The data were analysed using key statistics. The results showed that, from the students’ perspective, the most important issues in preparation for work are familiarisation with different jobs, guidance in searching for a suitable job, evaluation of the suitability of the working environment, integration of occupational safety into work skills, and acquiring conversational skills in the workplace. The selecti…
1H-NMR-Based Metabolomics in Autism Spectrum Disorder and Pediatric Acute-Onset Neuropsychiatric Syndrome
2022
We recently described a unique plasma metabolite profile in subjects with pediatric acute-onset neuropsychiatric syndrome (PANS), suggesting pathogenic models involving specific patterns of neurotransmission, neuroinflammation, and oxidative stress. Here, we extend the analysis to a group of patients with autism spectrum disorder (ASD), as a consensus has recently emerged around its immune-mediated pathophysiology with a widespread involvement of brain networks. This observational case-control study enrolled patients referred for PANS and ASD from June 2019 to May 2020, as well as neurotypical age and gender-matched control subjects. Thirty-four PANS outpatients, fifteen ASD outpatients, an…
Diagnostic Tools for Autism Spectrum Disorders by Gender: Analysis of Current Status and Future Lines
2021
Studies on the prevalence of autism spectrum disorders have shown gender disproportion. In recent years, there has been an increasing interest in this investigation area. There are two main research lines; the first is focused mostly on gender-related biological reasons that could account for low ASD prevalence in women (i.e., related to some protective factors related to hormones or the immune system, among others), and the second research line studies possible diagnostic biases. In the present study, a review of the latter line of research is made based on two main objectives: (a) analysis of possible biases in diagnostic tools and (b) other nonbiological ASD prevalence explained by gende…
Early Intervention with Parents of Children with Autism Spectrum Disorders: A Review of Programs
2020
The aim of this article was to analyze the evidence regarding the effectiveness of intervention programs for children with autism based on the participation of their parents. To obtain the data, a systematic search was carried out in four databases (PsycARTICLES (ProQuest), ERIC (ProQuest), PubMed (ProQuest), and Scopus). The retrieved documents were refined under the inclusion/exclusion criteria, and a total of 51 empirical studies were selected. These studies were first classified according to the function of the intervention objective and, later, by the methodology applied (19 studies were based on comprehensive interventions, 11 focused on the nuclear symptoms of autism spectrum disorde…
Intensive music therapy process with a male adult client diagnosed with autism
2016
Autism spectrum disorder (also called ASD) is the fastest growing disability. Research shows that music is a relational, emotional, and motivational medium that plays an essential role in field of music therapy, specifically for individuals with autism. This Master’s thesis aims at describing the intensive music therapy process with a 24 year-old Turkish-Cypriot male client diagnosed with ASD in a group setting concentrating on his four main areas of impairments (verbal/non verbal, social interaction, organization/perception and aspects of behavior) and how Creative Music Therapy affected such impaired areas. Results were in correspondence with previous studies about music therapy in treatm…
Behavioral aspects in children's brothers affected by Autism Spectrum Disorders
2018
Introduction: Autistic Spectrum Disorder (ASD) is a permanent and complex disability arising within the first three years of life characterized by a socio-communicative disorder and by fixed interests and repetitive behaviors. The present pilot study aims to evaluate behavioral aspects in a small population of siblings of ASD children. Material and methods: Population: 5 school-aged children (2 males, 3 females) (mean age 9.235 ± 2.041) were enrolled, as siblings of ASD children, and for comparison, 12 healthy (7 males, 5 females) children (average age 9,528 ± 3,351). All subjects underwent evaluation of the behavioral with Child Behavior Checklist (CBCL) scale. Results: The two groups were…
BCL11A intellectual developmental disorder: defining the clinical spectrum and genotype-phenotype correlations
2021
AbstractPurposeHeterozygous variants in BCL11A underlie an intellectual developmental disorder with persistence of fetal hemoglobin (BCL11A-IDD, a.k.a. Dias-Logan syndrome). We sought to delineate the genotypic and phenotypic spectrum of BCL11A-IDD.MethodsWe performed an in-depth analysis of 42 patients with BCL11A-IDD ascertained through a collaborative network of clinical and research colleagues. We also reviewed 33 additional affected individuals previously reported in the literature or available through public repositories with clinical information.ResultsMolecular and clinical data analysis of 75 patients with BCL11A-IDD identified 60 unique variants (30 frameshift, 7 missense, 6 splic…