Search results for "Autoimmunty"

Molecular approaches in autoimmunity and ageing: potential implications for future therapies.

My researches during my PhD were mainly focused on two aspects. The first one, was to study molecular aspects potentially implicated in autoimmunity pathogenesis, in order to identify new potential risk factors useful as therapeutic target. To this end, we focused on two severe and wasting systemic autoimmune diseases: systemic lupus erythematosus and systemic sclerosis. Pathogenesis of these diseases has still not clear and early diagnosis is difficult to identify because of complex and heterogeneous presentation of symptoms. A strong genetic association between HLA and disease susceptibility is well accept, nevertheless, other factors as oxidative stress, KIR and inflammatory cytokines ha…