Search results for "Axe"
showing 10 items of 550 documents
Impact of Hypoxia-Related Tumor Acidosis on Cytotoxicity of Different Chemotherapeutic Drugs In Vitro and In Vivo
2014
Extracellular acidosis in tumors leads to an activation of the p-glycoprotein (Pgp) drug transporter. In the present study the cytotoxicity of different chemotherapeutic drugs and its dependence on the Pgp activity during acidosis were analyzed in vitro and in vivo. Treating R3327-AT1, Pgp-positive tumor cells at pH 7.4 with daunorubicin, cisplatin or docetaxel led to marked apoptosis induction and cell death. Under acidic (pH 6.6) conditions cytotoxicity of daunorubicin or docetaxel was significantly reduced whereas cisplatin-induced cell death was almost pH-independent. Inhibiting Pgp with verapamil reversed the acidosis-induced chemoresistance against daunorubicin and docetaxel. The Pgp …
Cetuximab, fluorouracil (5-FU), cisplatin, and docetaxel as first-line treatment in patients with recurrent and/or metastatic squamous cell carcinoma…
2013
e17021 Background: This study investigates efficacy and toxicity of docetaxel added to cetuximab, cisplatin and 5-FU for patients with R/M SCCHN. We here report a planned second interim analysis to compare response rates between arms in order to decide on continuing to full accrual. Methods: Inclusion criteria were: stage III/IV R/M SCCHN and ECOG 0-1. Patients were randomized to arm A: cetuximab (standard dose) plus a maximum of 6 cycles of docetaxel (40 mg/m², day 1+8), cisplatin (40 mg/m², day 1+8) and 5-FU (2000 mg/m², day 1+8) or to arm B: cetuximab (standard dose), cisplatin (100 mg/m², day 1) and 5-FU (1000 mg/m², day 1-4). Treatment was administered until progression or intolerabil…
Maximum weight relaxed cliques and Russian Doll Search revisited
2015
Trukhanov et al. [Trukhanov S, Balasubramaniam C, Balasundaram B, Butenko S (2013) Algorithms for detecting optimal hereditary structures in graphs, with application to clique relaxations. Comp. Opt. and Appl., 56(1), 113–130] used the Russian Doll Search (RDS) principle to effectively find maximum hereditary structures in graphs. Prominent examples of such hereditary structures are cliques and some clique relaxations intensely discussed and studied in network analysis. The effectiveness of the tailored RDS by Trukhanov et al. for s-plex and s-defective clique can be attributed to their cleverly designed incremental verification procedures used to distinguish feasible from infeasible struct…
Twitter comme « corpus » en sciences du langage : questions méthodologiques et pistes de recherche
2017
Doctoral; L’avènement des corpus et des travaux sur corpus en sciences du langage ont amené la discipline à décrire des ressources sans cesse diversifiées, qu’il s’agisse de corpus de référence ou ad hoc. Les formes de communication médiées par ordinateur (computer-mediated communication) n’échappent pas cette tendance et ce d’autant plus qu’il s’agit de données numériques natives. Parmi les différents types recensés à ce jour, cette communication s’intéressera spécifiquement à Twitter et à ses potentialités pour la recherche linguistique.A partir d’un corpus compilé à la Maison des Sciences de l’Homme de Dijon – mais aussi des autres initiatives documentées sur la plateforme Ortolang – il …
Recognition in multicultural societies. Intergroup relations as second-order recognition
2015
Since the 1990s, the notion of social recognition has developed into a key concept for sociological theory. Recognition theory seems especially promising as a means of understanding intercultural conflicts, as the sociology of intercultural relations often addresses claims of recognition of a specific identity that is different from that of the main society. The aim of this article is to show that recognition theory can be used as a key concept in examining group inclusion in multicultural societies. Nevertheless, the existing theoretical approaches to recognition are insufficient for that purpose. Therefore, I develop my own approach to the recognition of minority groups as second-order re…
Sémantique discursive cognitive.
2022
Langue et connaissances sont dans la recherche actuelle travaillées sous l’angle du discours. Son étude linguistique permet d’identifier des figements en tant qu’expressions de routines sociales et cognitives. Cette approche exploite deux outils : les constructions en tant qu’appariements de sens et de forme, et les frames en tant qu’unités minimales de connaissances partagées. Il convient alors de construire théoriquement cette association, encore inédite en analyse du discours. Un protocole méthodologique de linguistique du corpus opérationnalise l’approche développée. Puis, une analyse empirique d’un corpus de publicités du vin issues de prospectus de supermarchés autrichiens permet de v…
The diagnosis and management of gastric cancer: Expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, B…
2011
Well-recognized experts in the field of gastric cancer discussed during the 12th European Society Medical Oncology (ESMO)/World Congress Gastrointestinal Cancer (WCGIC) in Barcelona many important and controversial topics on the diagnosis and management of patients with gastric cancer. This article summarizes the recommendations and expert opinion on gastric cancer. It discusses and reflects on the regional differences in the incidence and care of gastric cancer, the definition of gastro-esophageal junction and its implication for treatment strategies and presents the latest recommendations in the staging and treatment of primary and metastatic gastric cancer. Recognition is given to the ne…
Créances fiscales. Les créances fiscales ne naissent pas pour les besoins de la procédure
2010
International audience; (Limoges, ch. civ., 4 févr. 2010, RG n° 08/01717, Direction générale des finances publiques d'Epinal c/ Sté ALCEE, Rev. sociétés 2010. 197, obs. P. Roussel Galle)
Towards a reconstructive approach in political philosophy : Rosanvallon and Honneth on the pathologies of todays democracy
2016
This paper compares the democratic theories of Pierre Rosanvallon and Axel Honneth. The aim is to show how their work could form the basis of a ‘reconstructivist’ approach in political philosophy that rehabilitates the insights of 19th-century thinkers such as Guizot and Hegel concerning the benefits of combining political philosophy with history and sociology. Whereas the dominant procedural approaches in political philosophy tend to disconnect normative theory from the actual study of society and its history, Rosanvallon and Honneth argue that in order to understand the problems that face our democratic societies today we need a closer connection between theory and practice. Both have the…
Democratic institutions and recognition of individual identities
2016
This paper draws from two central intuitions that characterize modern western societies. The first is the normative claim that our identities should be recognized in an authentic way. The second intuition is that our common matters are best organized through democratic decision-making and democratic institutions. It is argued here that while deliberative democracy is a promising candidate for just organization of recognition relationships, it cannot fulfil its promise if recognition is understood either as recognition of ‘authentic’ collective identities or as recognition of too atomistic or individualized subjects. If deliberative democracy is to be understood as successfully providing au…