Search results for "Axel"
showing 10 items of 257 documents
The translocation of signaling molecules in dark adapting mammalian rod photoreceptor cells is dependent on the cytoskeleton.
2008
In vertebrate rod photoreceptor cells, arrestin and the visual G-protein transducin move between the inner segment and outer segment in response to changes in light. This stimulus dependent translocation of signalling molecules is assumed to participate in long term light adaptation of photoreceptors. So far the cellular basis for the transport mechanisms underlying these intracellular movements remains largely elusive. Here we investigated the dependency of these movements on actin filaments and the microtubule cytoskeleton of photoreceptor cells. Co-cultures of mouse retina and retinal pigment epithelium were incubated with drugs stabilizing and destabilizing the cytoskeleton. The actin a…
Impact of Hypoxia-Related Tumor Acidosis on Cytotoxicity of Different Chemotherapeutic Drugs In Vitro and In Vivo
2014
Extracellular acidosis in tumors leads to an activation of the p-glycoprotein (Pgp) drug transporter. In the present study the cytotoxicity of different chemotherapeutic drugs and its dependence on the Pgp activity during acidosis were analyzed in vitro and in vivo. Treating R3327-AT1, Pgp-positive tumor cells at pH 7.4 with daunorubicin, cisplatin or docetaxel led to marked apoptosis induction and cell death. Under acidic (pH 6.6) conditions cytotoxicity of daunorubicin or docetaxel was significantly reduced whereas cisplatin-induced cell death was almost pH-independent. Inhibiting Pgp with verapamil reversed the acidosis-induced chemoresistance against daunorubicin and docetaxel. The Pgp …
Cetuximab, fluorouracil (5-FU), cisplatin, and docetaxel as first-line treatment in patients with recurrent and/or metastatic squamous cell carcinoma…
2013
e17021 Background: This study investigates efficacy and toxicity of docetaxel added to cetuximab, cisplatin and 5-FU for patients with R/M SCCHN. We here report a planned second interim analysis to compare response rates between arms in order to decide on continuing to full accrual. Methods: Inclusion criteria were: stage III/IV R/M SCCHN and ECOG 0-1. Patients were randomized to arm A: cetuximab (standard dose) plus a maximum of 6 cycles of docetaxel (40 mg/m², day 1+8), cisplatin (40 mg/m², day 1+8) and 5-FU (2000 mg/m², day 1+8) or to arm B: cetuximab (standard dose), cisplatin (100 mg/m², day 1) and 5-FU (1000 mg/m², day 1-4). Treatment was administered until progression or intolerabil…
Recognition in multicultural societies. Intergroup relations as second-order recognition
2015
Since the 1990s, the notion of social recognition has developed into a key concept for sociological theory. Recognition theory seems especially promising as a means of understanding intercultural conflicts, as the sociology of intercultural relations often addresses claims of recognition of a specific identity that is different from that of the main society. The aim of this article is to show that recognition theory can be used as a key concept in examining group inclusion in multicultural societies. Nevertheless, the existing theoretical approaches to recognition are insufficient for that purpose. Therefore, I develop my own approach to the recognition of minority groups as second-order re…
The diagnosis and management of gastric cancer: Expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, B…
2011
Well-recognized experts in the field of gastric cancer discussed during the 12th European Society Medical Oncology (ESMO)/World Congress Gastrointestinal Cancer (WCGIC) in Barcelona many important and controversial topics on the diagnosis and management of patients with gastric cancer. This article summarizes the recommendations and expert opinion on gastric cancer. It discusses and reflects on the regional differences in the incidence and care of gastric cancer, the definition of gastro-esophageal junction and its implication for treatment strategies and presents the latest recommendations in the staging and treatment of primary and metastatic gastric cancer. Recognition is given to the ne…
Towards a reconstructive approach in political philosophy : Rosanvallon and Honneth on the pathologies of todays democracy
2016
This paper compares the democratic theories of Pierre Rosanvallon and Axel Honneth. The aim is to show how their work could form the basis of a ‘reconstructivist’ approach in political philosophy that rehabilitates the insights of 19th-century thinkers such as Guizot and Hegel concerning the benefits of combining political philosophy with history and sociology. Whereas the dominant procedural approaches in political philosophy tend to disconnect normative theory from the actual study of society and its history, Rosanvallon and Honneth argue that in order to understand the problems that face our democratic societies today we need a closer connection between theory and practice. Both have the…
Democratic institutions and recognition of individual identities
2016
This paper draws from two central intuitions that characterize modern western societies. The first is the normative claim that our identities should be recognized in an authentic way. The second intuition is that our common matters are best organized through democratic decision-making and democratic institutions. It is argued here that while deliberative democracy is a promising candidate for just organization of recognition relationships, it cannot fulfil its promise if recognition is understood either as recognition of ‘authentic’ collective identities or as recognition of too atomistic or individualized subjects. If deliberative democracy is to be understood as successfully providing au…
Insults, humour and freedom of speech
2016
In this article we argue that freedom of speech should be understood as a social freedom. In the public discussion after the Charlie Hebdo attacks, it has often been understood as an absolute right to say anything – to offend, to make a fool of others and of oneself, and to express any opinion regardless of the consequences. We challenge this view and propose that advocating freedom of speech without understanding its social foundations is misleading and counterproductive. Based on the critical social theories of Erich Fromm, Charles Taylor and Axel Honneth, we show that there is an alternative tradition in which freedom is fundamentally rooted in social relations and therefore requires re…
Low doses of paclitaxel potently induce apoptosis in human retinoblastoma Y79 cells by up-regulating E2F1.
2008
Paclitaxel (PTX) is an anticancer drug currently in phase II clinical trials. This study shows for the first time that low doses of PTX (5 nM) potently induce apoptosis in human retinoblastoma Y79 cells. The effect of PTX is accompanied by a potent induction of E2F1 which appears to play a critical role in the effects induced by PTX. PTX induced a dose- and time-dependent effect, with G2/M arrest, cyclines A, E and B1 accumulation and a marked modification in the status of Cdc2-cyclin B1 complex, the major player of the G2/M checkpoint. Apoptosis followed G2/M arrest. An early and prolonged increase in p53 expression with its stabilization by phosphorylation and acetylation and its nuclear …
Bronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosa
2014
The bronchial microbiome in severe COPD during stability and exacerbation in patients chronically colonised by Pseudomonas aeruginosa (PA), has not been defined. Our objective was to determine the characteristics of the bronchial microbiome of severe COPD patients colonised and not colonised by P. aeruginosa and its changes during exacerbation. COPD patients with severe disease and frequent exacerbations were categorised according to chronic colonisation by P. aeruginosa. Sputum samples were obtained in stability and exacerbation, cultured, and analysed by 16S rRNA gene amplification and pyrosequencing. Sixteen patients were included, 5 of them showing chronic colonisation by P. aeruginosa.…