Search results for "Azasteroids"

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Model‐based meta‐analysis of the time to first acute urinary retention or benign prostatic hyperplasia‐related surgery in patients with moderate or s…

2021

Aims Combination therapy of 5α‐reductase inhibitor and α‐blocker is a guideline‐endorsed therapeutic approach for patients with moderate‐to‐severe lower urinary tract symptoms or benign prostatic hyperplasia (LUTS/BPH) who are at risk of disease progression. We aimed to disentangle the contribution of clinical and demographic baseline characteristics affecting the risk of acute urinary retention or BPH‐related surgery (AUR/S) from the effect of treatment with drugs showing symptomatic and disease‐modifying properties. Methods A time‐to‐event model was developed using pooled data from patients (n = 10 238) enrolled into six clinical studies receiving placebo, tamsulosin, dutasteride or tamsu…

Malemedicine.medical_specialtydisease‐modifying propertiesCombination therapyProstatic HyperplasiaPlacebo030226 pharmacology & pharmacy03 medical and health scienceschemistry.chemical_compound0302 clinical medicinebaseline risk factorsLower urinary tract symptomsTamsulosinHumansMedicinePharmacology (medical)lower urinary tract symptoms030212 general & internal medicineacute urinary retentionPharmacologybenign prostatic hyperplasiadutasterideSulfonamidesbusiness.industryUrinary retentionHazard ratioOriginal ArticlesUrinary Retentionmedicine.diseaseDutasterideSurgeryTreatment OutcomechemistryAzasteroidstamsulosinOriginal ArticleDrug Therapy CombinationInternational Prostate Symptom Scoremedicine.symptombusinesstime‐to‐event modellingmedicine.drugBritish Journal of Clinical Pharmacology
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