Search results for "B-defensin"
showing 3 items of 3 documents
Valuation of Human,B-defensin 2 and 3 in sera of Helicobacter pylori infected patients
2013
In recent years, anti-microbial peptides have emerged as a critical component of host innate defense. These peptides are gene-encoded natural antibiotics expressed by immune and non-immune cell types including epithelia. Human beta defensin are disulphide linked, low molecular weight cationic peptides that are known to be a major components of innate immune defense mechanisms at mucosal surfaces. Their expression level differs between those that are constitutively expressed and those that are induced upon challenge with inflammatory or pathogen-derived stimuli. To date six members of the human-β-defensins (hBD1-6) family have been identified. Helicobacter pylori (H. pylori), a pathogenic bu…
LEVELS OF HBD2 AND HBD3 IN PATIENTS INFECTED AND NON-INFECTED BY HELICOBACTER PYLORI
2014
Introduction: Infection with Helicobacter pylori (H. pylori) evokes inflammatory and immune responses of the host, which most likely determine the clinical outcome of H. pylori infection. In the gastric epithelium, expression of human alpha-defensins, beta-defensins (hBD)-1, -2 and -3 has been detected in vivo. In particularly hBD3 as well hBD2 is known to be induced in gastric epithelial cells infection by the H. pylori and may be involved in the pathogenesis of H pylori-associated gastritis, possibly through its function as immune and inflammatory mediator. However, during prolonged infection, hBD3 was subsequently downregulated by the H. pylori virulence determinant CagA. Materials and M…
Polymorphisms of β-defensin genes in Valle del Belice dairy sheep
2011
The aim of this work was to study β-defensin 1 (SBD1) and β-defensin 2 (SBD2) genes in Valle del Belice dairy sheep in order to identify polymorphisms that can be utilized as markers of the analyzed genes, and search for the functional effects and roles of the identified polymorphisms (variation of the amino acid sequence of the protein and stability of mRNA molecule). The study was conducted on 300 randomly selected animals belonging to four flocks. A total of seven SNPs were identified, two in SBD1 and five in SBD2. The two SNPs identified in SBD2 coding region, at position 1659 and position 1667, were non-synonymous, leading to amino acid changes in the protein product. Nevertheless, the…