Search results for "B.2.3"
showing 2 items of 12 documents
Preparation and characterisation of optical and optoelectronic devices based in two-dimensional semiconductors
2020
In the Materials Science field, two-dimensional materials have gained the scientific community attention in recent years. The change and the appearance of novel properties when their thickness is reduced to nanometric scale has special interest for its fundamental properties study for, from this base, the design and its implementation in devices. The wide variety of materials with the possibility of being exfoliated at the two-dimensional level opens the field to different applications, from optoelectronic devices, detection and sensing, energy storage, catalysis, medical applications and quantum information technologies, among others. This thesis gathers results in both directions: a funda…
SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B
2014
A proper balance between saturated and unsaturated fatty acids (FAs) is required for maintaining cell homeostasis. The increased demand of FAs to assemble the plasma membranes of continuously dividing cancer cells might unbalance this ratio and critically affect tumour outgrowth. We unveiled the role of the stearoyl-CoA desaturase SCD5 in converting saturated FAs into mono-unsaturated FAs during melanoma progression. SCD5 is down-regulated in advanced melanoma and its restored expression significantly reduced melanoma malignancy, both in vitro and in vivo, through a mechanism governing the secretion of extracellular matrix proteins, such as secreted protein acidic and rich in cysteine (SPAR…