Search results for "BAV"

Hepatitis C virus infection in hemodialyzed patients.

2007

In spite of our present improved knowledge of the epidemiology and pathways of contamination of the hepatitis C virus (HCV), infection still remains a public health problem. One category of patients who have suffered greatly from the consequences of HCV infection is certainly that of hemodialysis patients. In the past, in fact, their need for transfusions exposed these patients to infection and, as a result, subjects on dialysis for over 15 years are today paying the price for those inevitable transfusions, as the virus and its pathways of contagion were unknown then. However, still today, albeit at a much lower prevalence, even subjects with a shorter dialysis age present a higher prevalen…

Ascending aorta phenotypic and genotypic changes in bicuspid aortic valve disease

2018

Bicuspid aortic valve (BAV) with left-right (L-R), right-non coronary (R-NC) and left-non coronary (L-NC) cusp fusion represents distinct pathological entities and the rate of aortic enlargement varies according to the pattern of cusps fusion (1). Here, we investigated the histological features of aneurysms associated to different BAV phenotypes and we looked for specific microRNAs (miRNA) as biomarkers of medial degeneration severity. Aortic specimens and blood were obtained from BAV patients treated surgically for the repair of thoracic aortic aneurysm and were divided into two groups: low grade medial degeneration (LGMD, n=10); high grade medial degeneration (HGMD, n=10). A control group…

Treating chronic hepatitis C in daily practice with PEG-IFN alfa2B and ribavirin. An Italian multicentre study

2004

Retreatment with pegylated interferon plus ribavirin of chronic hepatitis C non-responders to interferon plus ribavirin: A meta-analysis.

2009

BACKGROUND/AIMS: Efficacy of retreatment with pegylated interferon (PEG-IFN) plus ribavirin of non-responders to standard or pegylated IFN plus ribavirin has been assessed in various studies, but sustained virologic response (SVR) rates are variable and factors influencing efficacy and tolerability still remain incompletely defined. We aimed to focus on SVR rates and to identify factors influencing them in this meta-analysis. METHODS: MEDLINE as well as a manual search were used. Studies were included if they were controlled or uncontrolled trials, if they had been published as full-length papers and if they included non-responders to standard or pegylated IFN and ribavirin therapy. Fourtee…

"Le terribili giornate del maggio ’98" di Paolo Valera: la ricostruzione di una voce collettiva.

2010

Il reportage su "Le terribili giornate del maggio ’98" viene pubblicato da Paolo Valera nel 1913; l’opera, in questa sua veste definitiva, giunge a conclusione di un lungo percorso di sperimentazione che aveva visto lo scrittore comasco impegnato in una più che trentennale attività di poligrafo,vissuta tra tarda scapigliatura e naturalismo, tra giovanili adesioni al movimento anarchico e militanza nel partito socialista. Ne "Le terribili giornate" Valera rifiuta di proporsi quale indignata voce narrante, fonte unica di verità sui fatti e sulle interpretazioni; le scelte che egli attua in merito alla forma complessiva dell’opera, all’organizzazione della materia narrata e alla strutturazione…

Baijeri

1577

New developments in the management of hepatitis C virus infection: focus on boceprevir

2012

Chronic hepatitis C virus infection is an important public health problem, and the standard treatment (combination of pegylated interferon-α and ribavirin) has an effectiveness rate of only 40%-50%. Novel virus-specific drugs have recently been designed, and multiple compounds are under development. The approval for the clinical use of direct-acting antivirals in 2011 (boceprevir [BOC] and telaprevir, viral NS3 protease inhibitors) has increased recovery rates by up to 70%. Therefore, a highly effective treatment has been envisioned for the first time. This paper focuses on BOC and the implementation of new BOC-based treatment regimes.

Rapid detection and discrimination of fabaviruses by flow-through hybridisation with genus- and species-specific riboprobes

2015

Viruses cause significant damage in agricultural crops worldwide. Disease management requires sensitive and specific tools for virus detection and identification. Also, detection techniques need to be rapid to keep pace with the continuous emergence of new viral diseases. The genus Fabavirus is composed of five viruses infecting many economically important crops worldwide. This research describes the development of a procedure based on flow-through hybridisation (FTH), which is faster than and as sensitive as conventional hybridisation for virus detection in tissue-prints from infected plants. Six digoxigenin-labelled RNA probes were synthesised with two levels of specificity: (a) five spec…

Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

2000

Hepatitis C virus (HCV), the major causative agent of chronic and sporadic non-A, non-B hepatitis worldwide, is a distinct member of the Flaviviridae virus family. These viruses have in common a plus-strand RNA genome that is replicated in the cytoplasm of the infected cell via minus-strand RNA intermediates. Owing to the lack of reliable cell culture systems and convenient animal models for HCV, the mechanisms governing RNA replication are not known. As a first step towards the development of appropriate in vitro systems, we expressed the NS5B RNA-dependent RNA polymerase (RdRp) in insect cells, purified the protein to near homogeneity and studied its biochemical properties. It is a primer…

Zālāju kvalitātes ietekme uz dienastauriņu sugu daudzveidību Abavas ielejas sausajos zālājos

2015

Lanka A. (2015) Zālāju kvalitātes ietekme uz dienastauriņu sugu daudzveidību Abavas ielejas sausajos zālājos. Bakalaura darbs. Dienastauriņi ir pazīstami kā apputeksnētāji, bioloģiskās daudzveidības un klimata izmaiņu indikatori, kas apdzīvo zālāju biotopus. Sakarā ar zālāju izzušanu to pastāvēšana ir apdraudēta. Bakalaura darbā apskatīts, kā ar zālāju degradāciju saistītas veģetācijas izmaiņas ietekmē tauriņu sugu daudzveidību, un kā daudzveidība atšķiras pēc apsaimniekošanas atšķirīgos zālājos. Pētījumā noskaidrots, ka pastāv būtiska korelācija starp augu un dienastauriņu sugu skaitu, tauriņu sugu skaits starp dažādiem zalāju tipiem neatsķiras.