Search results for "BCB"

The ABCB4 p.T175A variant as potential modulator of hepatic fibrosis in patients with chronic liver diseases: Looking beyond the cholestatic realm

2017

Exome sequencing of a family with lone, autosomal dominant atrial flutter identifies a rare variation in ABCB4 significantly enriched in cases

2015

Background Lone atrial flutter (AFL) and atrial fibrillation (AF) are common and sometimes consequential cardiac conduction disorders with a strong heritability, as underlined by recent genome-wide association studies that identified genetic modifiers. Follow-up family-based genetic analysis also identified Mendelian transmission of disease alleles. Three affected members were exome-sequenced for the identification of potential causative mutations, which were subsequently validated by direct sequencing in the other 3 affected members. Taqman assay was then used to confirm the role of any mutation in an independent population of sporadic lone AFL/AF cases. Results The family cluster analysis…

The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients

2008

Background: Tacrolimus is a substrate of cytochrome P-450 (CYP) 3A enzyme and of the drug transporter ABCBl. We have investigated the effects of possible relevant CYP3A5 and ABCBl single nucleotide polymorphisms (SNPs) present in both donors and recipients on tacrolimus blood levels achieved in a population of 32 Caucasian liver transplant patients. Material/Methods: At 1, 3 and 6 months after transplantation, tacrolimus doses (mg/kg/day) and trough blood levels (C0) were determined. Polymerase chain reaction followed by restriction fragment length polymorphism analysis was used for gen-otyping CYP3A5*3 [6986A>G] as well as ABCBl at exons 21 [2677G>T] and 26 [3435C>T]. Results:87.5…

2015

Multidrug resistance is a prevailing phenomenon leading to chemotherapy treatment failure in cancer patients. In the current study two known cytotoxic pseudoguaianolide sesquiterpene lactones; neoambrosin (1) and damsin (2) that circumvent MDR were identified. The two cytotoxic compounds were isolated using column chromatography, characterized using 1D and 2D NMR, MS, and compared with literature values. The isolated compounds were investigated for their cytotoxic potential using resazurin assays and thereafter confirmed with immunoblotting and in silico studies. MDR cells overexpressing ABC transporters (P-glycoprotein, BCRP, ABCB5) did not confer cross-resistance toward (1) and (2), indic…

Lasīšanas veicināšanas pasākumi bērniem un jauniešiem Balvu centrālajā bibliotēkā

2018

Bakalaura darba mērķis – izpētīt Balvu Centrālās bibliotēkas lasīšanas veicināšanas pasākumus, kuri paredzēti bērniem no septiņu līdz astoņpadsmit gadu vecumam. Pētījuma teorētiskās bāzes pamatā ir Erika Ēriksona personības psihosociālā attīstības teorija, un filozofa Žana Piažē kognitīvā attīstības teorija, kas sniedz padziļinātāku ieskatu bērna personības attīstības posmos. Izvirzītā mērķa sasniegšanai pielietotas trīs pētniecības metodes – intervija, novērošana un dokumentu analīze. Darba ietvaros notika trīs intervijas, divu pasākumu un to dalībnieku novērošana un Balvu Centrālās bibliotēkas darba pārskatu analīze no 2010. līdz 2017. gadam. Pētījumā izvirzītā hipotēze apstiprinājās. Org…

Quadern de pràctiques de Tècniques d'anàlisi Genètic. Grau BCB

2013

El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. PROGRAMA DE CLASSES DE LABORATORI PRÀCTICA 1: LLIGAMENT D’UN FENOTIP MUTANT A UN MARCADOR MOLECULAR PRÀCTICA 2: ANÁLISI DE TÈTRADES ORDENADES (ESTIMA DE LA DISTÀNCIA AL CENTRÒMER EN SORDARIA FIMICOLA) PRÀCTICA 3: LOCALITZACIÓ CROMOSÒMICA PRECISA DE GENS MITJANÇANT L’ÚS DE DELECIONS EN DROSOPHILA MELANOGASTER PRÀCTICA 4: IDENTITAT GENÈTICA. OBTENCIÓ D’UNA EMPREMTA GENÈTICA A PARTIR DE DNA DE SALIVA I SANG, MITJANÇANT MARCADORS MOLECULARS I BIOQUÍMICS