Search results for "BDI"
showing 10 items of 208 documents
Cultural adaptation of the Smiling is Fun program for the treatment of depression in the Ecuadorian public health care system: A study protocol for a…
2021
Background Depression is one of the world's major health problems. Due to its high prevalence, it constitutes the first cause of disability among the Americas, where only a very low percentage of the population receives the adequate evidence-based psychological treatment. Internet-Based Interventions (IBIs) are a great alternative to reduce the treatment gap for mental disorders. Although there are several studies in low-and middle-income countries proving IBIs' feasibility and acceptability, there is still little evidence of the effectiveness in diverse social and cultural contexts such as Latin America. Methods Two studies will be described: Study 1 is focused on the cultural adaptation o…
Withanone Ameliorates Stress Symptoms in Caenorhabditis Elegans by Acting through Serotonin Receptors
2021
ABSTRACT Introduction Depression is responsible for 800 000 deaths worldwide, a number that will rise significantly due to the COVID-19 pandemic. Affordable novel drugs with less severe side effects are urgently required. We investigated the effect of withanone (WN) from Withania somnifera on the serotonin system of wild-type and knockout Caenorhabditis elegans strains using in silico, in vitro, and in vivo methods. Methods WN or fluoxetine (as positive control drug) was administered to wild-type (N2) and knockout C. elegans strains (AQ866, DA1814, DA2100, DA2109, and MT9772) to determine their effect on oxidative stress (Trolox, H2DCFDA, and juglone assays) on osmotic stress and heat stres…
"Table 18" of "Measurement of event shape and inclusive distributions at s**(1/2) = 130-GeV and 136-GeV."
1997
Difference of the Hemisphere Broadening, DBDIFF. Axis definition is from charged corrected plus neutral particles.
"Table 26" of "Tuning and test of fragmentation models based on identified particles and precision event shape data."
1996
Difference of the Hemisphere Broadening, BDIFF. Corrected to final state particles.
Modelling the occurrence of rainy days under a typical Mediterranean climate
2014
The statistical inference of the alternation of wet and dry periods in daily rainfall records can be achieved through the modelling of inter-arrival time-series, IT, defined as the succession of times elapsed from a rainy day and the one immediately preceding it. In this paper, under the hypothesis that ITs are independent and identically distributed random variables, a modelling framework based on a generalisation of the commonly adopted Bernoulli process is introduced. Within this framework, the capability of three discrete distributions, belonging to the Hurwitz–Lerch-Zeta family, to reproduce the main statistical features of IT time-series was tested. These distributions namely Lerch-se…
Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease
2010
Oxidative stress is involved in the pathogenesis of various neurodegenerative disorders, conventional antioxidant strategies have yet been of limited success. We have employed transgenic Caenorhabditis elegans expressing DsRed2 in dopaminergic neurons and CFP pan-neuronally, to characterize in larval and adult animals the effects of rotenone and 1-methyl-4-phenyl-pyridinium (MPP(+)) on the dopaminergic system. Investigating the antioxidant phenothiazine and different derived antipsychotic drugs, it was found that free phenothiazine exerted strong neuroprotection at the cellular level and resulted in a better performance in behavioral assays, whereas apomorphine and other dopamine agonists o…
Stories of Scylla and Charybdis in Homer and Vergil (Italian)
2007
A comparison between Odyssey's book 12 and Aeneis' book 3 shows some similarities in the handling of the myth: Scylla and Charybdis are hidden creatures, which the reader of both the poems can glimpse only behind the veil of the description of the seers Elenus and Circe. In the Vergilian version, however, there are traces of the rationalizations of the myth operated by Sallust and Lucrece.
Induction of stress resistance and extension of lifespan in Chaenorhabditis elegans serotonin-receptor knockout strains by withanolide A
2021
Abstract Introduction Approximately 300 million people worldwide suffer from depression. The COVID-19 crisis may dramatically increase these numbers. Severe side effects and resistance development limit the use of standard antidepressants. The steroidal lactone withanolide A (WA) from Withania somnifera may be a promising alternative. Caenorhabditis elegans was used as model to explore WA's anti-depressive and anti-stress potential. Methods C. elegans wildtype (N2) and deficient strains (AQ866, DA1814, DA2100, DA2109 and MT9772) were used to assess oxidative, osmotic or heat stress as measured by generation of reactive oxygen species (ROS), determination of lifespan, and mRNA expression of …
Generalized SCODEF Deformations on Subdivision Surfaces
2006
This paper proposes to define a generalized SCODEF deformation method on a subdivision surface. It combines an “easy-to-use” free-form deformation with a Loop subdivision algorithm. The deformation method processes only on vertices of an object and permits the satisfaction of geometrical constraints given by the user. The method controls the resulting shape, defining the range (i.e. the impact) of the deformation on an object before applying it. The deformation takes into account the Loop properties to follow the subdivision scheme, allowing the user to fix some constraints at the subdivision-level he works on and to render the final object at the level he wants to. We also propose an adapt…
Global Functional Analyses of Cellular Responses to Pore-Forming Toxins
2011
Here we present the first global functional analysis of cellular responses to pore-forming toxins (PFTs). PFTs are uniquely important bacterial virulence factors, comprising the single largest class of bacterial protein toxins and being important for the pathogenesis in humans of many Gram positive and Gram negative bacteria. Their mode of action is deceptively simple, poking holes in the plasma membrane of cells. The scattered studies to date of PFT-host cell interactions indicate a handful of genes are involved in cellular defenses to PFTs. How many genes are involved in cellular defenses against PFTs and how cellular defenses are coordinated are unknown. To address these questions, we pe…