Search results for "BEC"
showing 10 items of 947 documents
Outoja omakuvia : performatiivisuus ja kokemus Alison Bechdelin omaelämäkerrallisessa sarjakuvaromaanissa Fun Home
2013
Analysoin tutkimuksessani Alison Bechdelin omaelämäkerrallista sarjakuvaromaania Fun Home. A Family Tragicomic (2006). Fun Home on omaelämäkerran lisäksi elämäkerta Alisonin isästä, Bruce Bechdelistä. Bruce tekee itsemurhan Alisonin ollessa noin kaksikymmentävuotias ja jättää jälkeensä joukon vastauksettomia kysymyksiä – Fun Homessa Alison pohtii näitä kysymyksiä ja vertailee Brucen elämäntarinaa omaansa. Alison identifioituu lesboksi ja epäilee myös Brucen olleen homoseksuaali. Teoksessa on runsaasti intertekstuaalisuutta: keskeinen subteksti on esimerkiksi Ikaroksen ja Daidaloksen myytti, jonka käänteinen uudelleenkerronta kuvaa Alisonin ja Brucen välistä suhdetta. Tutkimuksen tavoitteena…
Tiedekulttuurien tasa-arvo tutkimuksen arvioinnissa : tutkimuksen kokonaisarvioinnin analyysi yhteiskuntatieteiden näkökulmasta
2012
Tutkimuksessa tarkastellaan Jyväskylän yliopistossa vuosina 2010 ja 2011 suoritettua tutkimuksen kokonaisarviointia. Tarkoituksena on selvittää, onko kokonaisarviointi ollut tasa-arvoinen, kun sitä tarkastellaan erilaisten tiedekulttuurien näkökulmasta. Tasa-arvoisuus on otettu kokonaisarvioinnissa yhdeksi johtavaksi periaatteeksi. Tutkimuksen aineistona on tutkimuksen kokonaisarvioinnin arviointiraportti, josta analyysin kohteeksi on valittu raportin yleinen ohjeistus sekä yhteiskuntatieteiden ja filosofian laitoksen arvioinnin osuus. Tutkimuksen teoreettisena viitekehyksenä on Michel Foucalt’lta lähtöisin oleva hallinnallisuuden teoria. Teorian avulla huomio voidaan kiinnittää ensinnäkin …
Recensione di Michael Kunkel, «... dire cela, sans savoir quoi... ». Samuel Beckett in der Musik von Gyorgy Kurtag und Heinz Holliger, Saarbrücken 20…
2010
L'articolo recensisce uno studio dedicato alla messa in musica di testi di S. Beckett in due compositori contemporanei di grande rilievo quali Holliger e Kurtag.
Beckwith–Wiedemann syndrome: multiple molecular mechanisms
2006
Beckwith–Wiedemann syndrome (BWS) is a congenital overgrowth condition with an increased risk of developing embryonic tumours, such as Wilms' tumour. The cardinal features are abdominal wall defects, macroglossia and gigantism. BWS is generally sporadic; only 10–15% of cases are familial. A variety of molecular aberrations have been associated with BWS. The only mutations within a gene are loss-of-function mutations in the CDKN1C gene, which codes for an imprinted cell-cycle regulator. CDKN1C mutations appear to be particularly associated with umbilical abnormalities, but not with increased predisposition to Wilms' tumour. In the remaining BWS subgroups, a disturbance of the tight epigeneti…
Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules.
1998
AbstractChromosome 11p15.5 harbors a gene or genes involved in Beckwith-Wiedemann syndrome that confer(s) susceptibility to Wilms' tumor, rhabdomyosarcoma, and hepatoblastoma. We have previously identified a transcript at 11p15.5 which encodes a putative membrane transport protein, designated organic cation transporter-like 2 (ORCTL2), that shares homology with tetracycline resistance proteins and bacterial multidrug resistance proteins. In this report, we have investigated the transport properties of ORCTL2 and show that this protein can confer resistance to chloroquine and quinidine when overexpressed in bacteria. Immunohistochemistry analyses performed with anti-ORCTL2 polyc.onal antibod…
Global variability in seawater Mg:Ca and Sr:Ca ratios in the modern ocean
2020
12 pages, 5 figures, supporting information https://doi.org/10.1073/pnas.1918943117.-- Data Availability. Our published databases are publicly accessible for readers, and they are deposited at the NOAA NCEI at https://data.nodc.noaa.gov/cgi-bin/iso?id=gov.noaa.nodc:0171017.-- Correction for Lebrato et al., Global variability in seawater Mg:Ca and Sr:Ca ratios in the modern ocean; Proceedings of the National Academy of Sciences of the USA 118(49): e2119099118 (2021); doi: 10.1073/pnas.2119099118; http://hdl.handle.net/10261/258054.-- This is Pacific Marine Environmental Laboratory contribution number 5046
Saccharomyces eubayanusandSaccharomyces uvarumassociated with the fermentation ofAraucaria araucanaseeds in Patagonia
2014
Mudai is a traditional fermented beverage, made from the seeds of the Araucaria araucana tree by Mapuche communities. The main goal of the present study was to identify and characterize the yeast microbiota responsible of Mudai fermentation as well as from A. araucana seeds and bark from different locations in Northern Patagonia. Only Hanseniaspora uvarum and a commercial bakery strain of Saccharomyces cerevisiae were isolated from Mudai and all Saccharomyces isolates recovered from A. araucana seed and bark samples belonged to the cryotolerant species Saccharomyces eubayanus and Saccharomyces uvarum. These two species were already reported in Nothofagus trees from Patagonia; however, this …
Glucose regulation and pain in older people-The Helsinki Birth Cohort Study
2021
Aims: To assess if individuals with diabetes or prediabetes report more pain or have increased use of pain medication compared to normoglycaemic individuals. Methods: Using cross-sectional data, we studied 928 men and 1075 women from the Helsinki Birth Cohort Study in 2001-2004 at a mean age of 61.5 years. Glucose regulation was assessed with a 2-h 75 g oral glucose tolerance test, and applying World Health Organization criteria, participants were defined as having normoglycaemia, prediabetes (impaired fasting glucose or impaired glucose tolerance), newly diagnosed diabetes or previously diagnosed diabetes. Self-reported pain intensity and interference during the previous 4 weeks was estima…
Natural products for the treatment of Type 2 Diabetes Mellitus
2015
Type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia. High blood sugar can produce long-term complications such as cardiovascular and renal disorders, retinopathy, and poor blood flow. Its development can be prevented or delayed in people with impaired glucose tolerance by implementing lifestyle changes or the use of therapeutic agents. Some of these drugs have been obtained from plants or have a microbial origin, such as galegine isolated from Galega officinalis, which has a great similarity to the antidiabetic drug metformin. Picnogenol, acarbose, miglitol, and voglibose are other antidiabetic products of natural origin. This review compiles the princi…
Influence of a collagen membrane and recombinant platelet-derived growth factor on vertical bone augmentation in implant-fixed deproteinized bovine b…
2012
Combinations of bone substitute block materials with membrane techniques as well as with growth factors are possible options to enhance the prognosis of vertical bone augmentation. Therefore, the aim of the pilot study was to compare the influence of a collagen membrane and a signal protein (rhPDGF-BB) on vertical bone augmentation with a stable fixed block material (deproteinized bovine bone [DBB]).In 12 rabbits, a DBB-block was implant-fixed on the tibia in a split-leg-design. Included were: DBB only (control), DBB + collagen membrane (test), DBB + rhPDGF-BB (test) and DBB + rhPDGF-BB + collagen membrane (test). 24 samples were examined after 3 (n = 12) and 6 weeks (n = 12). Calculated pa…