Search results for "BENEFIT"
showing 10 items of 471 documents
Impact of orphan drugs on Latvian budget
2016
Background Number of orphan medicinal products on the market and number of rare disease patients, taking these usually expensive products, are increasing. As a result, budget impact of orphan drugs is growing. This factor, along with the cost-effectiveness of orphan drugs, is often considered in the reimbursement decisions, directly affecting accessibility of rare disease therapies. The current study aims to assess the budget impact of orphan drugs in Latvia. Methods Our study covered a 5-year period, from 2010 to 2014. Impact of orphan drugs on Latvian budget was estimated from the National Health Service’s perspective. It was calculated in absolute values and relative to total pharmaceuti…
A Business-Driven Process Model for Knowledge Security Risk Management
2019
This chapter introduces a model to manage knowledge security risks in organizations. Knowledge security risk management is a process that should always be done in connection with the business benefits assessment and realization. The process model presented helps to identify knowledge security risks and provides a comprehensive approach to evaluating and balancing the costs and benefits of knowledge sharing and knowledge risk management and is discussed in light of the benefits realization process. The process model can be a valuable tool for practitioners aiming to develop knowledge sharing practices in companies, and at the same time need to consider the security of knowledge. It is also a…
Inhaled steroids and prevalence of osteoporosis in chronic obstructive pulmonary disease: Data from the DACCORD cohort
2020
Introduction: Osteoporosis is a frequent COPD comorbidity with age, female gender, smoking, immobility and the use of oral steroids (OCS) as common risk factors. The role of inhaled steroids (ICS) is still under debate. Methods: Baseline data from the real life cohort DACCORD were analyzed. The diagnosis of osteoporosis was based on patients’ reports of physician-based diagnoses. Associations of ICS exposure at time of inclusion and osteoporosis were examined by group comparisons and multivariable logistic regression analyses with age, gender, smoking, exacerbation history (EH) and FEV1% as covariates. To avoid interactions with other steroid containing medications, exposure to any corticos…
Asiakkuudenhallinta ja sen hyödyt sekä haasteet palveluyrityksissä
2015
Asiakkuudenhallinta hyödyttää yrityksen liiketoimintaa useilla eri tavoilla. Jatkuvasti kasvavan palvelusektorin yrityksille se luo paljon lisäarvoa asiakas-suhteiden hallinnan ja kehittämisen muodossa. Tässä kandidaatin tutkielmassa on tarkasteltu asiakkuudenhallinnan hyödyntämistä palveluyrityksissä. Lisäk-si tutkielmassa on arvioitu asiakkuudenhallinnan haasteita ja mahdollisia on-gelmia palveluyrityksissä ja palvelutuotannossa yleisesti. Aluksi on tarkasteltu asiakkuudenhallintaa yleisellä tasolla, määritelty keskeiset käsitteet, kuvattu asiakkuudenhallinnan yleiset vaiheet ja prosessit sekä tarkasteltu asiakkuu-denhallinnan toteuttamisessa hyödynnettäviä tietojärjestelmiä. Seuraavassa …
A phase III study of futibatinib (TAS-120) versus gemcitabine-cisplatin (gem-cis) chemotherapy as first-line (1L) treatment for patients (pts) with a…
2020
TPS600 Background: Pts with adv CCA have poor survival outcomes, and chemotherapy offers limited survival benefit (5-year survival rates, 5–10%; median overall survival [OS], 8–12 months). FGFR2 gene rearrangements are known to be early drivers of oncogenesis in ~15% of pts with intrahepatic (i) CCA. Futibatinib, an oral, highly selective, irreversible FGFR1-4 inhibitor has shown antitumor activity against a broad spectrum of FGFR-deregulated tumors in preclinical studies. In a previous study, futibatinib demonstrated clinical activity and tolerability in heavily pretreated pts with adv CCA harboring FGFR2 gene rearrangements. This phase 3 trial (FOENIX-CCA3) is designed to evaluate futiba…
BIOM-08. DNA METHYLATION-BASED SUBGROUPING PREDICTS SURVIVAL BENEFIT FROM LOMUSTINE/TEMOZOLOMID COMBINATION THERAPY IN MGMT PROMOTOR-METHYLATED GLIOB…
2021
Abstract BACKGROUND The CeTeG/NOA-09 trial showed that lomustine/temozolomide chemotherapy prolongs survival for newly diagnosed MGMT-methylated glioblastoma patients. Previous reports on temozolomide monotherapy suggested, that the survival benefit of temozolomide in MGMT-methylated tumors may be restricted to the RTK II methylation subgroup and absent in RTK I and MES subgroups. To identify patients with a particularly strong benefit from CCNU/TMZ, we explored the association of methylation subgroups with outcome after lomustine/temozolomide therapy. METHODS All patients from the CeTeG/NOA-09 trial with sufficiently available tumor tissue (n = 98) underwent 850K methylation array analysis…
Cancer and Pregnancy: A Comprehensive Review
2021
Simple Summary The co-occurrence of cancer and pregnancy is fortunately a rare event. It is a challenging situation for all involved parties, as the risks and benefits of oncological treatments should be balanced for both the mother and the offspring. This work offers guidance to clinicians regarding the choice of diagnostic and therapeutic procedures, as well as regarding the management of the pregnancy. Abstract Cancer diagnosis and treatment in pregnant women is a challenging situation. A multidisciplinary network of specialists is required to guide both, the expecting mother and the unborn child through the diagnostic workup and the cytotoxic therapy, by balancing the respective risks a…
Endringskapasitet – en nøkkel for å lykkes med gevinstrealisering i spesialisthelsetjenesten? : En studie av hvordan mellomledere opplever at endring…
2018
Masteroppgave i helse- og sosialinformatikk HSI500 - Universitetet i Agder 2018 Background: If an organisation is to reap the potential benefits of new technology, it must modify its work processes. However, the specialist health service appears to be experiencing significant challenges because it is constantly under pressure to change and improve its efficiency. This can weaken its capacity for change and, at worst, lead to long-term reductions in productivity and efficiency. Purpose: The purpose of this study is to examine how middle managers in the specialist health service feel they can influence developments in change capacity. The aim is to contribute to an awareness of the importance…
Challenges and opportunities for citrus wastewater management and valorisation: A review.
2022
Citrus wastewaters (CWWs) are by-products of the citrus fruit transformation process. Currently, more than 700 million of m³ of CWWs per year are produced worldwide. Until nowadays, the management of CWWs is based on a take-make-use-dispose model. Indeed, after being produced within a citrus processing industry, CWWs are subjected to treatment and then discharged into the environment. Now, the European Union is pushing towards a take-make-use-reuse management model, which suggests to provide for the minimization of residual pollutants simultaneously with their exploitation through a biorefinery concept. Indeed, the recovery of energy nutrients and other value-added products held by CWWs may…
Extended music education enhances the quality of school life
2013
The claim of whether music education can create social benefits in the school environment was tested in 10 Finnish schools with an extended music curricular class and control classes. The quality of school life (QSL) was assessed by a representative sample (N=735) of pupils at years 3 and 6 (9- and 12-years-olds). The results showed that extended music education enhances the QSL, particularly in areas related to general satisfaction about the school and a sense of achievement and opportunity for students. Differences related to the schools and gender did not account for the results. A follow-up study examined whether the increase in critical QSL variables was related to music. This analysis…