Search results for "BES"

showing 10 items of 3692 documents

Le caratteristiche di personalità nei pazienti obesi. Uno studio con il MCMI-III

2010

personality assessment obesity
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Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits

2014

In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for the synthesis of chylomicrons by intestinal cells to transport dietary lipids and cholesterol. We produced transgenic rabbits expressing permanently and ubiquitously a small hairpin RNA targeting the rabbit APOBEC1 mRNA. These rabbits exhibited a moderately but significantly reduced …

perte de poidsobesityApolipoprotein BAgricultural BiotechnologyGene Expressionlcsh:MedicinetransgenesisSmall hairpin RNAAnimals Genetically Modified0302 clinical medicinesirnaRNA interferenceGene expressionGene Knockdown TechniquesBiologie de la reproductionMedicine and Health SciencesTransgenesIntestinal MucosaRNA Small Interferinglcsh:Science[SDV.BDD]Life Sciences [q-bio]/Development Biology2. Zero hunger0303 health sciencesGene knockdownReproductive BiologyMultidisciplinarybiologyGenetically Modified OrganismsBiologie du développementapobec1; obesity; editing apob; apob100; apob48; chylomicron; intestine; rabbit; sirna; transgenesis; knockdownchylomicronknockdownAgricultureInherited Metabolic DisordersDevelopment BiologyobésitéCholesterolPhenotypeTransgenic Engineering[ SDV.BDLR ] Life Sciences [q-bio]/Reproductive BiologyLiverapobapob48Gene Knockdown Techniquesanimal transgéniqueRNA Interferencelipids (amino acids peptides and proteins)RabbitsGenetic EngineeringResearch ArticleBiotechnologyexpression géniqueTransgeneAPOBEC-1 DeaminaseMolecular Sequence DatarabbitDiet High-Fat03 medical and health sciencesintestinCytidine DeaminaseWeight Loss[SDV.BDD] Life Sciences [q-bio]/Development BiologyAnimalsHumanslapinRNA Messenger[ SDV.BDD ] Life Sciences [q-bio]/Development BiologyintestineTriglycerides[SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology030304 developmental biologyapobec1Base SequenceGenetically Modified AnimalsAPOBEC1editinglcsh:RBiology and Life Sciences[SDV.BDLR]Life Sciences [q-bio]/Reproductive BiologyMolecular biologyapob100DyslipidemiaMetabolic Disordersbiology.proteinlcsh:QRNA EditingApolipoprotein B-48030217 neurology & neurosurgery
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Nanotubi di titanato con Au in superficie per la foto-ossidazione selettiva di alcoli ad aldeidi

2022

photocatalysisTitanate nanotubes
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Sievietes maksts mikrofloras un PH izmaiņu veicinošie faktori un nozīme uz turpmāko sievietes reproduktīvo veselību

2022

KOPSAVILKUMS Ievads. Normālas maksts mikrofloras sastāva dominē pienskābes baktēriju sugas, kas izdalot pienskābi un ūdeņraža peroksīdu, nodrošina normālu maksts pH un pasargā maksti no patogēno mikroorganismu invāzijas un proliferācijas. Sievietes maksts mikroflorai ir būtiska nozīme uz sievietes reproduktīvo veselību. Izmaiņas maksts mikroflorā ne tikai paaugstina risku uz infekcijas attīstību, bet var ietekmēt arī sievietes auglību un normālu grūtniecības norisi. Darba mērķis. Darba mērķis ir pierādīt, ka jaunais intīmās zonas kopšanas produkts ir pielietojams praksē, subjektīvi uzlabo sievietes labsajūtu, ginekoloģisko veselību un uzlabo maksts pH. Materiāli un metodes. Prospektīvs, dub…

pienskābes baktērijasmaksts pHmaksts mikrofloraMedicīnareproduktīvā veselība
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¿Una herencia incómoda? Percepciones del patrimonio islámico peninsular en el mundo moderno (siglos XV-XVII)

2022

El propósito de esta tesis es dar respuesta a si hubo una intención manifiesta por parte de los cristianos del antiguo Reino de Valencia por borrar la huella de la presencia islámica tras la toma de Balansiya, ya que apenas se conservan a día de hoy vestigios de su pasado, de ahí la primera parte del título de nuestro trabajo: ¿Una herencia incómoda? A través de una revisión bibliográfica y de documentación de archivo analizamos si se produjo verdaderamente tal rechazo tras la conquista de Šarq al-Andalus, a la vez que mostramos un estudio comparativo con lo sucedido en otras partes del territorio peninsular. Todo ello en un marco cronológico que se inicia con la conquista de Granada y fina…

pinturamezquitasUNESCO::HISTORIApercepciónandalusítejidosrenacimientotrofeoherenciaarte suntuarioinscripciones árabescultura materialedad modernabotínvestigiospatrimoniobaños de vapor
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Introduction à la modélisation de l'écriture manuscrite par des courbes Bézier Rationnelles massiques

2019

National audience; L’article est une introduction à la modélisation de l’écriture manuscrite. La représentation de l’écriture cursive in- terfère, selon l’approche hors ligne ou en ligne, sur la robustesse des algorithmes de reconnaissance des caractères manuscrits, de l’identification des auteurs et de leur signature. Les caractéristiques de base de l’écriture cursive que sont les traits et leur inclinaisons, les boucles, les pleins et déliés peuvent être modélisés par des courbes. Des méthodes existent. Elles reposent sur les B-splines et leur points de contrôle. Dans un premier temps, des traits, les auteurs proposent une modélisation, rebroussements, boucles, arrondis, pleins et déliés.…

points massiques[MATH] Mathematics [math][MATH.MATH-MG] Mathematics [math]/Metric Geometry [math.MG][MATH]Mathematics [math]écriture cursive[MATH.MATH-MG]Mathematics [math]/Metric Geometry [math.MG]courbes Bézier massiques
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DES-polyacetals as polymer therapeutics for the treatment of prostate cancer

2012

Esta tesis se centra en el diseño de nuevos conjugados polímero-fármaco sensibles a pH para usarse como agentes únicos o en terapia de combinación para el tratamiento del cáncer hormono-dependiente, en particular cáncer de próstata. Éstos conjugados se basan en sístemas poliacetalicos previamente descritos en los que el fármaco forma parte de la cadena principal del polímero. En el microambiente tumoral o después de la absorción celular por endocitosis, el descenso del pH encontrado en el compartimiento ácido del endosoma lisosomal, desencadena la degradación del polímero y como consecuencia la liberación del fármaco que se difunde fuera en el citosol. Para el diseño de éstos sistemas, la n…

polymer-drug conjugatesUNESCO::QUÍMICAUNESCO::CIENCIAS MÉDICAScáncer de próstatadiethylstilbestrolpolyacetalsprostate cancer:CIENCIAS MÉDICAS [UNESCO]:QUÍMICA [UNESCO]
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Necesario, pero no deseado. Las advertencias de Thomas Hobbes sobre los peligros de la multitud, el populismo y la democracia

2016

The purpose of this article is to analyse Hobbes’s understanding of democracy. The first part of the article analyses the role of democracy in the social contract. It aims to show how there exists a democratic element at the beginning of the process of social contract, in which the multitude is transformed into a people. However, after the first social contract is made, Hobbes aims to reduce the power of the people by leading the process of social contract on to another level, on which the power of the people is assigned to a representative of the sovereign power, for example a monarch. The second part of the article aims to explain the practical reasons, provided by Hobbes in different par…

populismodemocracymultitudesocial contractfilosofía políticacontrato socialteoría políticapolitical theorypopulismpopulismiyhteiskuntasopimusHobbes ThomasThomas Hobbesdemokratiapolitical philosophydemocraciamultitud7207.04
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On the Porosity of Free Boundaries in Degenerate Variational Inequalities

2000

Abstract In this note we consider a certain degenerate variational problem with constraint identically zero. The exact growth of the solution near the free boundary is established. A consequence of this is that the free boundary is porous and therefore its Hausdorff dimension is less than N and hence it is of Lebesgue measure zero.

porosityLebesgue measureApplied MathematicsDegenerate energy levelsMathematical analysisZero (complex analysis)Boundary (topology)nonhomogeneous p-Laplace equationfree boundaryobstacle problemHausdorff dimensionVariational inequalityObstacle problemFree boundary problemAnalysisMathematicsJournal of Differential Equations
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Federaliści i rozłam między klasycznością a modernością

2014

The article shows how the classical political thinking, based on civic virtues, and modernist thinking, based on individualism and self-interest, formed the basis of the U.S. Constitution. The Founding Fathers did not realize the full extent of the rift between classicism and modernity. When, as a result of intellectual discussions and practice of social life, this divide began to become more and more obvious, there has been a transition from the classical to the modernist paradigm in American politics. However, the dispute between classicism and modernity still continues and takes on new forms. On the one hand, contemporary political thinking is seen as a triumph of modernism, in which the…

post-modernityThomas JeffersonJohn LockedifferenceFederalistsAlexander HamiltonMartin Heideggerfounding fathers of the United StatesindividualismJohn AdamsThomas HobbesWestern civilizationdeconstructionJames Madisonclassical traditionmodernityvirtueRuch Filozoficzny
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