Search results for "BH"

showing 10 items of 1357 documents

La biblioteca en el espacio ciudadano. Reflexiones a partir de la investigación española sobre el usuario de la información, 2005-2019

2021

Los últimos datos sobre el escaso uso de las bibliotecas españolas cuestionan la utilidad de este servicio en la cotidianidad ciudadana. Paralelamente, un movimiento dentro de la Biblioteconomía y Documentación que habla de la biblioteca social, participativa o del bien común, busca ampliar el espacio ciudadano que ésta ocupa. Este trabajo se centra en las implicaciones que para este propósito tienen las últimas investigaciones españolas sobre usuarios de la información. Primero, los datos revelan la escasa participación de los profesionales en estas investigaciones. Segundo, abundan aquellas que se centran en la evaluación de unidades de información, pero escasean las dirigidas a obtener d…

AA. Library and information science as a field.españaBH. Information needs and information requirements analysis.research:LINGÜÍSTICA [UNESCO]biblioteconomía y documentacióninvestigaciónBA. Use and impact of information.spaininformation behaviorcomportamiento informacionalUNESCO::LINGÜÍSTICA
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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Secretor status and ABH antigens expression in patients with oral lesions

2007

Objectives: The aim of this work was to investigate the secretor status of patients with oral pre-cancerous and cancerous lesions and ABH antigens expression in fixed tissue sections of these patients. Study design: To reveal A, B and H antigens in tissue sections of patients with precancerous and cancerous oral lesions (n= 54) we used a modified specific red cell adherence technique (SRCA-test). Normal endothelial cells expressed ABH antigens, the presence of indicator erythrocytes at the lumen of the blood vessels served as a built in positive control. The test results were graded from negative adherence to very strongly positive adherence. Negative adherence was defined as a complete abs…

ABH antigensUNESCO::CIENCIAS MÉDICAScancer:CIENCIAS MÉDICAS [UNESCO]Secretor Status
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recensione a Christian Wolff, Einleitende Abhandlung über Philosophie im allgemeinen, hrsg. von Günter Gawlick und Lothar Kreimendahl, Frommann-Holbo…

2007

recensione

Abhandlung über Philosophie
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R. D. G. M. Ad peccatorem Sodomitam

1485

Sign.: a6, b4. - Data aprox., al voltant de 1485 L. gòt. - 30-31 lín. - Min. p. inic. - Filigr.: àguila desplegada

Abús sexual envers els infants Obres anteriors a 1800Abús sexual envers els infants Obres anteriors al 1800DIG-BH
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Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome

2021

Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p &lt

Acute coronary syndromemedicine.medical_specialtyAnemiaMujermedicine.medical_treatment:enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus [ENFERMEDADES]Enfermedad cardiovascularAnciano:Otros calificadores::/diagnóstico [Otros calificadores]DonesDietética y nutriciónDiseaseMalalties coronàriesRevascularizationelderlyArticleCoronary diseasesInfarto del miocardio sin elevación del STnon-ST-segment elevation acute coronary syndromesDiabetes mellitusInternal medicine:Other subheadings::/diagnosis [Other subheadings]medicineClinical endpointEndocrinologíaWomen:Diagnosis::Prognosis [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Diabetis - Prognosi:diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Diabetisbusiness.industryST elevationDiabetesRGeneral Medicinemedicine.disease:Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus [DISEASES]Diabetes mellitus tipo 2diabetes mellitusDiferències entre sexes:enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::síndrome coronario agudo [ENFERMEDADES]Medicinewomenbusiness:Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Acute Coronary Syndrome [DISEASES]Kidney disease
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Real Pragmatica sanccion, para que en este Reyno de Valencia se forme un nuevo batallon, con nombre de la Milicia de la custodia del Reyno, de numero…

1665

Sign.: A4 Esc. reial a la port. (grav. xil.)

Administracio militar Comunitat Valenciana S.XVII Obres anteriors a 1800DIG-BH
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Aneurysm clipping following endovascular coil embolization: A report of two cases

2009

Abstract BACKGROUND: Treatment of intracranial aneurysms by Guglielmi detachable coil (GDC) embolization is a useful therapeutic alternative to surgery. This procedure is attractive as a minimally invasive approach to treat cerebral aneurysms; however, is not devoid of complications or failure and retreatment, with either a surgical or endovascular technique, may often be required. CASE REPORTS: Two cases are presented in which surgery was required after coil embolization. In one case, surgical treatment was performed one month later because of regrowth and subsequent bleeding of the aneurysm. In the second case, surgical treatment was carried out six months later because of recanalization …

AdolescentSettore MED/27 - Neurochirurgiaaneurysm rest; cerebral aneurysm; guglielmi detachable coils; retreatmentIntracranial AneurysmMiddle AgedEmbolization Therapeuticcerebral aneurysmguglielmi detachable coilsCerebral aneurysm coli embolizzation subharachnoid hemorrhageCerebral aneurysm clippingHumansFemaleaneurysm restretreatment
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The effect of MPEG audio compression on multidimensional set of voice parameters

2002

The MPEG-1 Layer 3 compression schema of audio signal, or commonly known as mp3, has caused a great impact in recent years as it has reached high compression rates while also conserving a high sound quality. Previous listening tests have shown that music and speech samples compressed at high bitrates are virtually indistinguishable from the original samples, but very little is known about how compression acoustically affects the voice signal. In Experiment 1 the spectral composition of original and compressed speech signals were analyzed by means of the Long-Term Average Spectrum using the Computerized Speech Laboratory (Kay Elemetrics Corp. (Pine Brook, NJ, USA)). In Experiment 2 a set of …

AdultMaleSpeech AcousticsSubharmonicAudio signalVerbal BehaviorVoice QualityComputer scienceAcousticsSpeech recognitionmedia_common.quotation_subjectFidelityLPN and LVNSpeech AcousticsFrequency spectrumSpeech and HearingPhonationArts and Humanities (miscellaneous)VoiceHumansFemaleDynamic range compressionSound qualitySpectral compositionmedia_commonLogopedics Phoniatrics Vocology
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Erweiterung des Kantismus, Umgestaltung der Metaphysik. Il giovane Viktor von Weizsäcker lettore di Kant

2015

This paper aims to examine the relationships between the research of young Viktor von Weizsäcker and Kant’s critical thinking. Starting from the criticism of Driesch’s Neovitalism, here are considered some of the major contributions of Weizsacker in the years 1911-1926, in order to show its path between criticism of knowledge, metaphysics, construction of a biology and a medical anthropology.

Aesthetics Biology Philosophical Anthropologylcsh:BH1-301lcsh:BSettore M-FIL/04 - Esteticalcsh:Philosophy. Psychology. Religionlcsh:AestheticsLebenswelt. Aesthetics and philosophy of experience.
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