Search results for "BIP"

Age at First Episode Modulates Diagnosis-Related Structural Brain Abnormalities in Psychosis.

2016

Brain volume and thickness abnormalities have been reported in first-episode psychosis (FEP). However, it is unclear if and how they are modulated by brain developmental stage (and, therefore, by age at FEP as a proxy). This is a multicenter cross-sectional case-control brain magnetic resonance imaging (MRI) study. Patients with FEP (n = 196), 65.3% males, with a wide age at FEP span (12-35 y), and healthy controls (HC) (n = 157), matched for age, sex, and handedness, were scanned at 6 sites. Gray matter volume and thickness measurements were generated for several brain regions using FreeSurfer software. The nonlinear relationship between age at scan (a proxy for age at FEP in patients) and…

Tract-specific white matter structural disruption in patients with bipolar disorder

2011

Benedetti F, Absinta M, Rocca MA, Radaelli D, Poletti S, Bernasconi A, Dallaspezia S, Pagani E, Falini A, Copetti M, Colombo C, Comi G, Smeraldi E, Filippi M. Tract-specific white matter structural disruption in patients with bipolar disorder. Bipolar Disord 2011: 13: 414–424. © 2011 The Authors. Journal compilation © 2011 John Wiley & Sons A/S. Objectives:  A growing body of evidence suggests that, independent of localized brain lesions, mood disorders can be associated with dysfunction of brain networks involved in the modulation of emotional and cognitive behavior. We used diffusion tensor (DT) tractography to quantify the presence and extent of structural injury to the connections betwe…

Role of Seroalbumin in the Cytotoxicity of cis-Dichloro Pt(II) Complexes with (N^N)-Donor Ligands Bearing Functionalized Tails

2018

Given the potent anticancer properties of cisdiamminedichloroplatinum( II) and knowing its mode of action, we synthesized four new cis-[PtCl2(N^N)] organoplatinum complexes, two with N-substituted pbi ligands (pbiR = 1-R-2-(2-pyridyl)benzimidazole) (namely, 1 and 2) and two more with 4,4′-disubstituted bpy ligands (bpy = 2,2′-bipyridine) (namely, 3 and 4). We explored their cytotoxicity and ability to bind to deoxyguanosine monophosphate (dGMP), DNA, and albumin models. By 1H NMR and UV−vis spectroscopies, circular dichroism, agarose gel electrophoresis, differential scanning calorimetry measurements, and density functional theory calculations, we verified that only 3 can form aquacomplex s…

Sensing Chiral Drugs by Using CdSe/ZnS Nanoparticles Capped withN-Acetyl-L-Cysteine Methyl Ester

2013

Chiral quantum dots (QDs), differing in their core or shell size and, consequently, in their optical properties, were synthesized by the treatment of commercially available amine-capped quantum dots with methyl ester N-acetyl-L-cysteine (CysP). Interestingly, their colloidal methanol solutions remain stable for several months. Their NMR and IR spectra were in accordance with CysP binding to the QD surface through two anchoring groups; its thiolate (strongly bound) and the carbonyl group of its ester (weaker bound) group, whereas their circular dichroism (CD) spectra showed a new broad redshifted band, suggesting that the attachment to the QD surface modified the conformational equilibrium t…

Enantiomerically pure trinuclear helicates via diastereoselective self-assembly and characterization of their redox chemistry.

2014

A tris(bipyridine) ligand 1 with two BINOL (BINOL = 2, 2′-dihydroxy-1, 1′-binaphthyl) groups has been prepared in two enantiomerically pure forms. This ligand undergoes completely diastereoselective self-assembly into D2-symmeteric double-stranded trinuclear helicates upon coordination to copper(I) and silver(I) ions and to D3-symmetric triple-stranded trinuclear helicates upon coordination to copper(II), zinc(II), and iron(II) ions as demonstrated by mass spectrometry, NMR and CD spectroscopy in combination with quantum chemical calculations and X-ray diffraction analysis. According to the calculations, the single diastereomers that are formed during the self-assembly process are strongly …

A delay time bound for distributed parameter circuits with bipolar transistors

1990

We prove here a stability theorem concerning a parabolic system of equations with non-linear boundary conditions that governs the behaviour of a class of networks in which the bipolar transistors operating under large-signal conditions are interconnected with reg-lines modelled by telegraph equations

2013

The amyloid-β42 (Aβ42) peptide plays a crucial role in the pathogenesis of Alzheimer’s disease (AD), the most common neurodegenerative disorder affecting the elderly. Over the past years, several approaches and compounds developed for the treatment of AD have failed in clinical studies, likely in part due to their low penetration of the blood–brain barrier (BBB). Since nanotechnology-based strategies offer new possibilities for the delivery of drugs to the brain, this technique is studied intensively for the treatment of AD and other neurological disorders. The Aβ42 lowering drug flurbiprofen was embedded in polylactide (PLA) nanoparticles by emulsification-diffusion technique and their pot…

When can an equational simple graph be generated by hyperedge replacement?

1998

Infinite hypergraphs with sources arise as the canonical solutions of certain systems of recursive equations written with operations on hypergraphs. There are basically two different sets of such operations known from the literature, HR and VR. VR is strictly more powerful than HR on simple hypergraphs. Necessary conditions are known ensuring that a VR-equational simple hypergraph is also HR-equational. We prove that two of them, namely having finite tree-width or not containing the infinite bipartite graph, are also sufficient. This shows that equational hypergraphs behave like context-free sets of finite hypergraphs.

Counting degree sequences of spanning trees in bipartite graphs: A graph‐theoretic proof

2019

Patología dual y consumo de tóxicos en pacientes con trastorno bipolar: estado de la cuestión

2006

Objetivo: Explorar la comorbilidad en consumo de tóxicos y patología dual de pacientes con Trastorno Bipolar. Metodología: Revisión crítica de la bibliografía secundaria obtenida a través de la base de datos Medline asi como de diversas monografias sobre el tema. Resultados: Los pacientes bipolares presentan una alta prevalencia de abuso o dependencia de sustancias, siendo el alcohol el principal tóxico consumido, seguido por la cocaína. Este consumo se refleja en un empeoramiento del curso y pronóstico del trastorno afectivo. Conclusiones: Las cifras más altas de comorbilidad del trastorno bipolar corresponden a los trastornos por abuso y dependencia de sustancias. De hecho, los trastornos…