Search results for "BLAST"
showing 10 items of 2136 documents
Origin of asymmetries in X-ray emission lines from the blast wave of the 2014 outburst of nova V745 Sco
2016
The symbiotic nova V745 Sco was observed in outburst on 2014 February 6. Its observations by the Chandra X-ray Observatory at days 16 and 17 have revealed a spectrum characterized by asymmetric and blue-shifted emission lines. Here we investigate the origin of these asymmetries through three-dimensional hydrodynamic simulations describing the outburst during the first 20 days of evolution. The model takes into account thermal conduction and radiative cooling and assumes a blast wave propagates through an equatorial density enhancement. From the simulations, we synthesize the X-ray emission and derive the spectra as they would be observed with Chandra. We find that both the blast wave and th…
3D MHD modeling of the expanding remnant of SN 1987A : role of magnetic field and non-thermal radio emission
2018
Aims. We investigate the role played by a pre-supernova (SN) ambient magnetic field on the dynamics of the expanding remnant of SN 1987A and the origin and evolution of the radio emission from the remnant, in particular, during the interaction of the blast wave with the nebula surrounding the SN. Methods. We model the evolution of SN 1987A from the breakout of the shock wave at the stellar surface to the expansion of its remnant through the surrounding nebula by 3D MHD simulations. The model considers the radiative cooling, the deviations from equilibrium of ionization, the deviation from temperature-equilibration between electrons and ions, and a plausible configuration of the pre-SN ambie…
Capturing blast waves in granular flow
2007
Abstract In this paper we continue the analysis of compressible Euler equations for inelastic granular gases described by a granular equation of state due to Goldshtein and Shapiro [Goldshtein A, Shapiro M. Mechanics of collisional motion of granular materials. Part 1: General hydrodynamic equations. J Fluid Mech 1995;282:75–114], and an energy loss term accounting for inelastic collisions. We study the hydrodynamics of blast waves in granular gases by means of a fifth-order accurate scheme that resolves the evolution under different restitution coefficients. We have observed and analyzed the formation of a cluster region near the contact wave using the one-dimensional and two-dimensional v…
X-ray emission from the Vela SNR shock region: Spectral fitting with a non-equilibrium ionization model
1994
We report on the 5′ scale spectral analysis of the X‐ray emission from a region near the edge of the Vela SNR with a Non‐Equilibrium Ionization (NEI) model. We have found significant variations of temperature, density, ionization time and interstellar absorption. We have identified an overdense region with higher density and lower temperature than the surrounding medium. That can be interpreted as an ISM cloudlet recently shocked by the blast wave, not yet in thermal equilibrium. Our independent determination of the Vela SNR distance is in agreement with the most recent results based on ROSAT All‐Sky Survey data. Our analysis indicates the occurrence of fast electron‐ion energy equipartitio…
The colocalizations of pulp neural stem cells markers with dentin matrix protein-1, dentin sialoprotein and dentin phosphoprotein in human denticle (…
2021
Abstract Background The primary dentin, secondary dentin, and reactive tertiary dentin are formed by terminal differentiated odontoblasts, whereas atubular reparative tertiary dentin is formed by odontoblast-like cells. Odontoblast-like cells differentiate from pulpal stem cells, which express the neural stem cell markers nestin, S100β, Sox10, and P0. The denticle (pulp stone) is an unique mineralized extracellular matrix that frequently occurs in association with the neurovascular structures in the dental pulp. However, to date, the cellular origin of denticles in human dental pulp is unclear. In addition, the non-collagenous extracellular dentin matrix proteins dentin matrix protein 1 (DM…
A study of the Candida albicans cell wall proteome
2008
Considering the importance of proteins in the structure and function of the cell wall of Candida albicans, we analyzed the cell wall subproteome of this important human pathogen by LC coupled to MS (LC-MS) using different protein extraction procedures. The analyzed samples included material extracted by hydrogen fluoride-pyridine (HF-pyridine), and whole SDS-extracted cell walls. The use of this latter innovative procedure gave similar data as compared to the analysis of HF-pyridine extracted proteins. A total of 21 cell wall proteins predicted to contain a signal peptide were identified, together with a high content of potentially glycosylated Ser/Thr residues, and the presence of a GPI mo…
Neural cell pattern formation on glass and oxidized silicon surfaces modified with poly(N-isopropylacrylamide)
1996
Control over the adsorption of proteins and over the adsorption and spatial orientation of mammalian cells onto surfaces has been achieved by modification of glass and other silicon oxide substrates with poly(N-isopropylacrylamide) (PNIPAM). The functionalization of the substrates was achieved either by a polymer-analogous reaction of aminosilanes with reactive N-(isopropylacrylamide) (NIPAM)-copolymers and by copolymerization of NIPAM with surface-bound methacrylsilane. The obtained coatings were characterized by FT-1R, ellipsometry, and surface plasmon resonance measurements. The adsorption of two proteins-fibrinogen and ribonuclease A-on these surfaces was studied in situ by real time su…
Methods of spatial cluster detection in rare childhood cancers: Benchmarking data and results from a simulation study on nephroblastoma
2021
Abstract The potential existence of spatial clusters in childhood cancer incidence is a debated topic. Identification of rare disease clusters in general may help to better understand disease etiology and develop preventive strategies against such entities. The incidence of newly diagnosed childhood malignancies under 15 years of age is 140/1,000,000. In this context, the subgroup of nephroblastoma represents an extremely rare entity with an annual incidence of 7/1,000,000. We evaluated widely used statistical approaches for spatial cluster detection in childhood cancer (Ref. [22] Schundeln et al., 2021, Cancer Epidemiology). For the simulation study, random high risk clusters of 1 to 50 ad…
Efficient selection of silenced primary cells by flow cytometry
2007
Background: RNA interference has emerged as a new and potent tool to knockdown the expression of target genes and to investigate their functions. For short time experiments with mammalian cell lines, RNA interference is typically induced by transfecting small interfering RNAs (siRNAs). Primary cells constitute important experimental systems in many studies because of their similarity to their in vivo counterparts; however, transfection of these cells has been found to be difficult. As a consequence, RNA interference of primary cells may result in mixed phenotypes because of the simultaneous presence in the same preparation of transfected and nontransfected cells. This may be particularly in…
RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation
2009
BACKGROUND: Changes in chromosome number or structure as well as supernumerary centrosomes and multipolar mitoses are commonly observed in human tumors. Thus, centrosome amplification and mitotic checkpoint dysfunctions are believed possible causes of chromosomal instability. The Retinoblastoma tumor suppressor (RB) participates in the regulation of synchrony between DNA synthesis and centrosome duplication and it is involved in transcription regulation of some mitotic genes. Primary human fibroblasts were transfected transiently with short interfering RNA (siRNA) specific for human pRb to investigate the effects of pRb acute loss on chromosomal stability. RESULTS: Acutely pRb-depleted fibr…