Search results for "BLAST"

BLAST Database with all accesible non-tuberculous mycobacteria genomic sequences (Oct, 2018)

2019

In our work "Towards next generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics" (https://doi.org/10.1101/569384 ). We look for M. tuberculosis genes that are not present in organisms other tan MTBC. This database corresponds with the described database of 4,277 NTM assemblies.

A new strategy in selecting oocytes using cumulus cells analysis of specific molecules of the apoptotic pathway, according to the ability to reach bl…

2015

Study question: The aim of the research was to investigate the apoptosis rate of individual cumulus cell–oocyte complexes (COC), associated to the level of p-Akt, to verify the difference between oocytes who produce embryos able to reach the blastocyst stage compared with embryos arrested during the in vitro colture. Summary answer: It was demonstrated that DNA fragmentation in cumulus cells was remarkably lower in patients who achieved a pregnancy after ICSI cycles, related to the quality of oocytes and embryos. Akt pathway plays a critical role in the regulation of cell survival, and most growth factors activate this pathway. What is known already: Studies on oocyte maturation have shown …

Acetylcysteine therapy for chronic hepatitis C: are its effects synergistic with interferon alpha? A pilot study.

2008

This trial reports the 6-month results of a pilot study using lymphoblastoid interferon alpha (IFNalpha) and acetylcysteine (N-acetylcysteine) separately and in combination in patients with chronic hepatitis C, genotype 1b, who were nonresponders to previous treatment with recombinant IFNalpha alone.21 patients were randomly divided into three groups of seven each. Group A was treated with lymphoblastoid IFNalpha 6MU three times a week for 6 months; group B received the same schedule of lymphoblastoid IFNalpha as group A plus acetylcysteine 1200 mg/day per os in two administrations, and group C received only acetylcysteine 1200 mg/day per os in two administrations.Mean serum alanine aminotr…

Peripheral ameloblastoma: A case report

2020

Background Ameloblastoma is a rare tumor which develops from odontogenic epithelium and its remnants and it occurs in the jaws. Peripheral ameloblastomas are rare and benign extraooseous ameloblastomas which effects soft tissues. This case report declares a peripheral ameloblastoma which is a rare type of ameloblastoma. Material and methods 34 year old female patient referred with a complaint of a gingival growth at right lower premolar area. A firm and granular surfaced gingival growth with the color of pink and red and having 1.5x1 cm sizes was observed at the mentioned area. With an incision from lower right second incisor tooth to lower right second molar tooth a flap from bone was made…

26P Cellulose beads prepared in deep eutectic solvent function as carrier and cytoprotective encapsulation matrix for CAR-T cells in T-cell therapy a…

2020

Wild-type JAK2 secondary acute erythroleukemia developing after JAK2-V617F-mutated primary myelofibrosis.

2009

A 54-year-old female patient developed acute erythroleukemia after an 8-year course of primary myelofibrosis. The latter harbors the JAK2-V617F mutation and was treated with hydroxyurea and anagrelide. A bone marrow trephine biopsy disclosed 2 morphologically distinct areas of chronic primary myelofibrosis and acute erythroleukemia. Microdissection and a separate molecular pathological analysis was performed. Although the activating JAK2-V617F mutation was not maintained in blasts of acute erythroleukemia, it was detectable in the chronic phase of primary myelofibrosis, indicating that this mutation did not play a role in the leukemic transformation of erythroid cells.

Konfokale Laser-Scanning-Mikroskopie (CLSM): Histotomographie veränderter Zahnhartgewebe bei pathologischer Mundhöhlenökologie

1997

There is no consensus regarding the aetiology of radiation-induced caries. Lesion formation is assumed to originate either from direct radiogenic damage of the hard tissue or from the indirect effects correlated with radioxerostomia. A comparative study is presented of sound teeth (group 1), teeth with documented radiation caries (group 2), teeth after in situ radiation (group 3): 60 Gy, fractionated) and teeth after in vitro radiation (group 4: 500-2500 Gy). Radiations were carried out with a 60Co source. The dentoenamel junction was studied with confocal laser scanning microscopy (CLSM). Axial sections of the teeth were used either fresh or embedded in Technovit (sawing-grinding technique…

Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts in vitro

2010

Oral Diseases (2011) 17, 194–199 Objectives:  Bisphosphonate-associated osteonecrosis of the jaw (BP-ONJ) is a side effect in patients being treated with bisphosphonates. The bisphosphonates most often associated with BP-ONJ are the highly potent nitrogen-containing bisphosphonates, e.g. pamidronate or zoledronate. In terms of BP-ONJ aetiology, several theories are being discussed: inhibition of bone remodelling, effect on soft tissues, and antiangiogenic effect of bisphosphonates. The aim of this in vitro study was to investigate the effect of different potent bisphosphonates on osteoblasts, fibroblasts and human umbilicord vein endothelial cells (HUVEC). Materials and methods:  Three nitr…

Neue Erkenntnisse zur Ätiologie der sogenannten Strahlenkaries

1997

Fragestellung Die Atiologie der Strahlenkaries wird trotz vieler Untersuchungen kontrovers diskutiert: Die These einer direkten radiogenen Lasion des Zahnhartgewebes steht der einer indirekten Pathogenese uber die Radioxerostomie gegenuber.

Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostat…

2017

Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module undergo self-assembly in aqueous media to afford core-shell nanospheres or nanocapsules, depending on the nanoprecipitation protocol, with high docetaxel (DTX) loading capacity. The blank and loaded nanoparticles have been fully characterized by dynamic light scattering (DLS), ζ-potential measurements and cryo-transmission electron microscopy (cryo-TEM). The data are compatible with the distribution of the drug between the nanoparticle core and the shell, where it is probably anchored by inclusion of the DTX aromatic moieties in βCD cavities. Indeed, the release kinetics …