Search results for "BM"
showing 10 items of 1459 documents
Correlation between serum and saliva cortisol concentrations at rest and in response to submaximal exercise
2014
Tämän Pro-gradu tutkielman tarkoituksena oli selvittää varusmiespalveluksen ensimmäisen 9 viikon vaikutusta veren ja syljen kortisolin lepoarvoihin, kortisolin vastetta harjoitteluun sekä korrelaatioita seerumin ja syljen kortisolin välillä eri viikoilla ja päivän aikana. Tutkittavina olivat 41 varusmiestä Kainuun Prikaatista (ikä19.6 ± 0.3 v). Varusmiehet suo-rittivat 45-minuuttia kestävän submaksimaalisen marssitestin viikoilla 2,4,7 ja 9. Syljen ja seerumin kortisoli mitattiin aamulla heti heräämisen jälkeen, ennen harjoitusta ja välittömästi harjoituksen jälkeen. Psyykkistä kuormittumista tutkimuksen aikana mitattiin lyhennetyllä 26 kysymyksen POMS kyselyllä, jonka tarkoituksena oli sel…
Das ritual der unterwerfung Stefan Nemanjas unter Maunel I. Komnenos (1172)
2013
This article investigates the ceremonial of the subjection of the Serbian zupan Stefan Nemanja to the Byzantine emperor Manuel I Komnenos (1172) and compares it with similar events of the period in question. It argues for a strong influence of western forms of conflict resolution (?deditio?) in the ceremonial.
Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120.
2015
International audience; Modified nucleotide 5-methylcytosine (m(5)C) is frequently present in various eukaryotic RNAs, including tRNAs, rRNAs and in other non-coding RNAs, as well as in mRNAs. RNA: m(5)C-methyltranferases (MTases) Nop2 from S. cerevisiae and human proliferation-associated nucleolar antigen p120 are both members of a protein family called Nop2/NSUN/NOL1. Protein p120 is well-known as a tumor marker which is over-expressed in various cancer tissues. Using a combination of RNA bisulfite sequencing and HPLC-MS/MS analysis, we demonstrated here that p120 displays an RNA:m(5)C-MTase activity, which restores m(5)C formation at position 2870 in domain V of 25S rRNA in a nop2 Delta …
Absolute quantification of noncoding RNA by microscale thermophoresis
2019
Abstract Accurate quantification of the copy numbers of noncoding RNA has recently emerged as an urgent problem, with impact on fields such as RNA modification research, tissue differentiation, and others. Herein, we present a hybridization‐based approach that uses microscale thermophoresis (MST) as a very fast and highly precise readout to quantify, for example, single tRNA species with a turnaround time of about one hour. We developed MST to quantify the effect of tRNA toxins and of heat stress and RNA modification on single tRNA species. A comparative analysis also revealed significant differences to RNA‐Seq‐based quantification approaches, strongly suggesting a bias due to tRNA modifica…
Taste and oral microbiota
2021
International audience
Role of human metabolizing enzymes in food perception
2022
Flavor is the main factor determining food acceptability. Flavor corresponds to the combination of the signals from the gustatory system, the olfactory system and the trigeminal system. Interactions between proteins and flavor molecules in oral/nasal cavities are proposed to modulate flavor perception through a series of events knowns as perireceptor events. Among these proteins involved in this modulation are found enzymes mainly known for their role in the detoxification process. These enzymes are able to recognize a large panel of molecules. We proposed to explore the role of these enzymes in food perception. We demonstrated that enzymatic activities present in the oral epithelium and sa…
The question of Organic Unity in Flavour: The whole is not equal to the sum of the parts
2021
International audience
Role of odorant-binding proteins in Drosophila melanogaster chemosensory perception
2019
Chemoperception is used by animals to detect nutritive food and avoid toxic compounds. It also allows animals to identify suitable ecological niche and mating partners. Like many other insects, Drosophila melanogaster possesses a very sensitive chemosensory ability and can detect and discriminate a wide panel of semiochemicals. Chemosensory detection is mostly mediated by olfactory and gustatory systems involving several multigene chemoreceptor families. Volatile and non-volatile chemical compounds entering the sensory organ (sensillum) must be solubilized before being transported through the hydrophilic sensillum lymph bathing the dendrites of chemosensory neurons. These perireceptor event…
Quale migliore approccio riabilitativo nella cervicoartrori secondo le linee guida EBM? nostra esperienza
2017
La Cervicoartrosi è un’artropatia di tipo evolutivo la cui base anatomica è rappresentata da un processo degenerativo con inizio nelle cartilagini articolari che vanno incontro a fenomeni di usura, proliferazioni marginali, eburneizzazione dei capi ossei. L’incidenza tende ad essere in costante aumento per l’allungamento della vita media, interessando maggiormente il sesso femminile con un rapporto di 3:1. L’artrosi cervicale clinicamente si manifesta con dolore in regione cervico- dorsale, contrattura dei muscoli paravertebrali, limitazione del ROM fino a possibili manifestazioni neurologiche. Si può inoltre giungere ad una insufficienza vasomotoria di tipo funzionale, dipendente dalla pos…
Introduction: Localisation and the theoretical impasse?
2018
International audience