Search results for "BN"
showing 10 items of 1136 documents
Reliģiski-filozofiski raksti, 20
2016
Katrā no rakstiem, kas publicēti šajos "Reliģiski-filozofiskos rakstos", šķiet, iespējams saskatīsim gan pagātnes sprostā patvērušos brīvību ar tās apreibinošajās ilūzijām par neatkarību ārpus sprosta, gan nojaust neatrisināmo un reizēm iznīcinošo dilemmu starp gara un reālo pasauli, starp spēli un brīdi, kad spēle beidzas. Piemēram, par pagātnē iesprostotas virtuālās pasaules konstruēšanu, kuras brīvībā izlaušanās mērāma iznīcinātu dzīvību tūkstošos, mums stāsta Māris Kūlis savā rakstā “Islāma valsts propaganda digitālajā laikmetā”. Uzsverot, ka Islāma valsts īstenotais militārais un ārkārtīgi agresīvais džihāds ar vēl nepieredzētām sekmēm ir izveidojis sinkrētisku reliģiskās degsmes un mū…
Molecular genetics of autosomal dominant retinitis pigmentosa (ADRP): a comprehensive study of 43 Italian families
2005
Retinitis pigmentosa is the most common form of retinal degeneration and is heterogeneous both clinically and genetically. The autosomal dominant forms ( ADRP) can be caused by mutations in 12 different genes. This report describes the first simultaneous mutation analysis of all the known ADRP genes in the same population, represented by 43 Italian families. This analysis allowed the identification of causative mutations in 12 of the families (28% of the total). Seven different mutations were identified, two of which are novel (458delC and 6901C --> T (P2301S), in the CRX and PRPF8 genes, respectively). Several novel polymorphisms leading to amino acid changes in the FSCN2, NRL, IMPDH1, and…
Retinal Sensibility to Drugs in Normal Rats and Carriers of Inherited Retinal Degeneration
1972
Secondary retinitis pigmentosa of pseudo-retinitis pigmentosa can be brought about by certain diseases, especially exanthematic or viral ones.
Fully automatic saliency-based subjects extraction in digital images
2013
In this paper we present a novel saliency-based technique for the automatic extraction of relevant subjects in digital images. We use enhanced saliency maps to determine the most relevant parts of the images and an image cropping technique on the map itself to extract one or more relevant subjects. The contribution of the paper is two-fold as we propose a technique to enhance the standard GBVS saliency map and a technique to extract the most salient parts of the image. The GBVS saliency map is enhanced by applying three filters particularly designed to optimize the performance for the task of relevant subjects extraction. The extraction of relevant subjects is demonstrated on a manually ann…
Protective effect of adenylate deaminase (from Penicillium lanoso-viride) against acute infections in mice
1996
We examined the effects of the immunomodulator-adenylate deaminase (E.C. 3.5.4.6) from Penicillium lanoso-viride on experimental mice infections. Prophylactic intraperitoneal administration of adenylate deaminase (ADA) increased survival time and numbers of survivors after infection with Salmonella typhimurium, Pseudomonas aeruginosa and influenza A (H3N2) virus. Protection against influenza virus after intranasal ADA application was also observed. The influence of ADA was time and dose dependent. The most pronounced protection was obtained by administration of 3 U ADA/mice 24 h prior to infection. ADA had no antibiotic effect against these bacterial strains. Protective effects of ADA were …
Cystic Fibrosis Transmembrane Conductance Regulator Interacts with Multiple Immunoglobulin Domains of Filamin A
2010
Mutations of the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) that impair its apical localization and function cause cystic fibrosis. A previous report has shown that filamin A (FLNa), an actin-cross-linking and -scaffolding protein, interacts directly with the cytoplasmic N terminus of CFTR and that this interaction is necessary for stability and confinement of the channel to apical membranes. Here, we report that the CFTR N terminus has sequence similarity to known FLNa-binding partner-binding sites. FLNa has 24 Ig (IgFLNa) repeats, and a CFTR peptide pulled down repeats 9, 12, 17, 19, 21, and 23, which share sequence similarity yet differ from the other FLN…
Repozytorium instytucjonalne wobec Zintegrowanego Systemu Informacji o Nauce i Szkolnictwie Wyższym
2017
W artykule przedstawiono doświadczenia Biblioteki Głównej Uniwersytetu Opolskiego w tworzeniu instytucjonalnego repozytorium opartego na wcześniej funkcjonującym systemie ewidencji publikacji. Lokalnie gromadzone dane o publikacjach przekazywane są następnie, na podstawie obowiązujących aktów normatywnych regulujących System Informacji o Nauce, do ministerialnych systemów teleinformatycznych. W tekście omówiono również problemy związane z gromadzeniem i przekazywaniem danych o publikacjach do Modułu Sprawozdawczego Polskiej Bibliografii Naukowej, jednego z modułów Zintegrowanego Systemu Informacji o Nauce i Szkolnictwie Wyższym.
Assessment of drainage network analysis methods to rank sediment yield hotspots
2021
This paper aims to test different methods used for assessing sediment yield indices to identify hotspots and rank sediment yield hotspots. This process includes the assessment of the entropy weight...
Methodologies for the Determination of Blood Alpha1 Antitrypsin Levels: A Systematic Review
2021
Background: The study of hematic concentrations of alpha1 antitrypsin (AAT) is currently one step in the diagnosis of AAT deficiency. To try to clarify the relevance of the laboratory techniques, we carried out a systematic review of the literature. Methods: Studies evaluating the quantification of AAT in peripheral blood were searched in PubMed in July 2021. The selection criteria included (1) any type of study design that included a quantification of AAT in peripheral blood; (2) studies written in English or Spanish; (3) studies evaluating human beings; and (4) studies involving adults. Results: Out of 207 studies, the most frequently used techniques were nephelometry (43.9%), followed by…
Genetics and genomics of BNCT among basics and perspectives
2017
The Boron neutron capture therapy (BNCT) bases its therapeutic action on the selective ability to induce DNA damage of tumor cells with the aim to cause their death by apoptosis or necrosis, preserving as much as possible the normal cells. The genetic variability is an evolutionary mechanism of species survival and improvement according to which diversity in genetic configurations exists among individuals of a population, revealed also in different tolerance to insults and reparative ability of DNA damage induced by physical and chemical agents. A tumor, due to its intrinsic genomic instability, acquires the mutator phenotype and may, during the cell duplications, generate in the same indiv…