Search results for "BP"
showing 10 items of 672 documents
Jāņa Ezeriņa noveļu iepazīšana 11. klasē
2016
Diplomdarba „Jāņa Ezeriņa noveļu iepazīšana 11. klasē” mērķis ir izstrādāt metodiskās sistēmas variantu Jāņa Ezeriņa personības un noveļu iepazīšanai vispārējās vidējās izglītības mācību iestādē 11. klasē, kā arī veicināt vērtību nozīmes un izziņas darbību, problēmjautājumu aktualizāciju un pašaktualizāciju literatūras mācību stundās. Darbam ir piecas nodaļas ar apakšnodaļām, ievads, secinājumi un pielikumi. Pirmajā nodaļā apzināta literatūra un apkopoti galvenie fakti par literatūru kā mācību priekšmeta specifiku. Otrajā nodaļā izzināta Jāņa Ezeriņa personība, aprakstīta noveļu specifika un novelēs paustās vērtības. Trešajā nodaļā aprakstīta skolotāja gatavošanās darbam klasē, raksturotas …
EPR/alanine dosimetry for two therapeutic proton beams
2016
Abstract In this work the analysis of the electron paramagnetic resonance (EPR) response of alanine pellets exposed to two different clinical proton beams employed for radiotherapy is performed. One beam is characterized by a passive delivery technique and is dedicated to the eyes treatment (OPTIS2 beam line). Alanine pellets were irradiated with a 70 MeV proton beam corresponding to 35 mm range in eye tissue. We investigated how collimators with different sizes and shape used to conform the dose to the planned target volume influence the delivered dose. For this purpose we performed measurements with varying the collimator size (Output Factor) and the results were compared with those obtai…
Insights into mRNP biogenesis provided by new genetic interactions among export and transcription factors.
2012
Abstract Background The various steps of mRNP biogenesis (transcription, processing and export) are interconnected. It has been shown that the transcription machinery plays a pivotal role in mRNP assembly, since several mRNA export factors are recruited during transcription and physically interact with components of the transcription machinery. Although the shuttling DEAD-box protein Dbp5p is concentrated on the cytoplasmic fibrils of the NPC, previous studies demonstrated that it interacts physically and genetically with factors involved in transcription initiation. Results We investigated the effect of mutations affecting various components of the transcription initiation apparatus on the…
Two novel members of OBP family identified in the honeybee : sexual dimorphism and development studies
1998
International audience
Xenopus Laevis and Xenopus Tropicalis have different number of OBP genes : Xlaeobp and Xtroobp
2008
International audience
Identification of a lysyl residue defining the binding specificity of a human odorant-binding protein
2008
International audience
Novel canine odorant binding proteins
2022
The present invention relates to the use of a sequence chosen among Seq ID No 3, Seq ID No l, Seq ID No 2, Seq ID No 4, Seq ID No 5, Seq ID No 6, Seq ID No 7, Seq ID No 8, and functional variants thereof, as an odorant binding protein (OBP).
Implication of an odorant-binding protein in precopulatory behaviour and interaction with the bacterial microbiota
2023
Chemoreception allows animals to detect nutritive food and avoid toxic compounds. Volatile and non-volatile chemical compounds, which are detected by olfactory and gustatory sensory organs, can trigger feeding and reproductive behaviours in animals such as Drosophila melanogaster. Inside chemosensory organs, perireceptor proteins like odorant-binding proteins (OBPs) serve to transport odorant and tastant molecule to dedicated receptors. OBPs are not only involved in chemoreception but also in several other functions. A recent study revealed an interaction between insect microbiota and OBP expression while another one showed that microbes can promote nutrient harvesting on food. In our proje…
Clinical Impact of GATA2 Mutations in Acute Myeloid Leukemia Patients Harboring CEBPA Mutations: A Study of the AML Study Group (AMLSG)
2013
Abstract Background Based on their association with certain biological and clinical features as well as their prognostic significance, mutations in the CCAAT/enhancer-binding protein-alpha (CEBPA) gene have been included as a provisional entity into the 2008 World Health Organization (WHO) classification of myeloid neoplasms. CEBPA mutations (CEBPAmut) are mainly found in acute myeloid leukemia (AML) with normal cytogenetics, and approximately 60% of the mutated patients (pts) carry biallelic mutations. Several studies showed that in particular pts with double mutant CEBPA (CEBPAdm) have a favorable outcome compared to all others. Recently, mutations in the transcription factor GATA2 were i…
Validation of the High-Risk Prognostic Score Defined By the Presence of Mutations in NRAS or TP53 in a Cohort of 497 Patients with Acute Myeloid Leuk…
2020
INTRODUCTION Older AML patients have a different mutational landscape compared to younger patients. The prognostic classification of AML proposed by the European Leukemia Net (2017) is based on the presence of mutations in FLT3 (ITD), NPM1, CEBPA, RUNX1, ASXL1 and TP53. However, our group has identified a high-risk prognostic score in older patients with AML, who are undergoing treatment with azacitidine or low-dose cytarabine plus fludarabine, which predict a shorter survival. OBJECTIVE Validation of the previously identified high-risk prognostic score, defined by the presence of mutations in NRAS or TP53, in 3 cohorts of patients with AML who have been studied by NGS with a custom panel i…