Search results for "BREAST"
showing 10 items of 1871 documents
Effect of cadmium on MDA-MB231 breast cancer cells
2006
We demonstrated that treatment of estrogen receptor-negative (ER-) MDA-MB231 breast cancer cells with 5 M Cd for 96h resulted in an about 50% reduction of cell number
P38 MAPK pathway is involved in cadmium response by MDA-MB231 breast cancer cells
2007
Type V collagen regulates apoptosis-related gene expression in breast cancer cells
2008
Involvement of PKCη in type V collagen-induced apoptosis on 8701-BC breast cancer cells
2007
Metabolic Signature of Breast Cancer Patients Negative and Positive to 18F-FDG PET Srceening.
2011
Metabolic signature of breast cancer patients negative and positive to 18F-FDG PET screening.
2010
Breast cancer cell growth/motility is influenced by metal compounds
2019
Triple-negative breast cancer (TNBC) is a highly "aggressive" malignant neoplasm with limited treatment options due to the lack of expression of estrogen and progesterone receptors and HER2/neu. In search of novel molecules displaying anti-TNBC activities, the TNBC cell line MDA-MB231 was exposed to cadmium chloride and/or manganese chloride, and a biological characterization of the effect observed was performed. The data obtained demonstrate a cytotoxic effect exerted by cadmium chloride with drastic changes affecting gene expressions and production of reactive oxygen species. Conversely, manganese chloride was effective in increasing cell number and promoting cell invasive ability. Such e…
the proximal leptin gene promoter is regulated by ppar gamma agonist in MCF-7 and MDA-MB-231 breast cancer cells
2009
Breast cancer proteomics: from research to clinical applications.
2008
The exponentially increasing volume of information extracted from genomic and proteomic applications on cancer, while providing new insights into molecular composition of cancer cells and tissues, imposes new challenges on data rationalization as a tool for clinically relevant biomarker discovery. Breast cancer represents the most frequent and potentially aggressive type of cancer and, moreover, it is one of the most enigmatic and poorly predictable in its evolution, likely because it includes several different forms that behave differently among patients. Current clinical parameters for breast cancer diagnosis and cure are: tumour size, axillary lymph node status, histological grading and …
Subcellular distribution of calpain-1 and calpain-2 as a key event for calpain-mediated functions in physiological and neoplastic mammary models
2019
Calpains are a family of calcium-dependent proteases, which modulate their substrates rather than degrade them in such a way that modifies them. Calpains deregulations have been determined as an aggravating factor of different diseases, including cancer. Nevertheless, there are no clear records about the particular contribution of each calpain isoform in physiological processes and how these isoforms are deregulated in pathological conditions. In vivo, each calpain isoform recognizes specific proteins as substrates, and it has been suggested that calpains subcellular localization might determine their substrate recognition, and consequently their functions. In the present study we have expl…