Search results for "BREAST"
showing 10 items of 1871 documents
JAHA, a novel histone deacetylase inhibitor: cytotoxic effect on triple-negative breast cancer cells
2013
Study of the epi- / genomic dysregulation of breast cancer in women under 35 years and evaluation of cellular models
2019
El cáncer de mama tiene la tasa de incidencia más alta de todos los cánceres en mujeres en todo el mundo. Este cáncer suele tener un excelente pronóstico con un 80% de supervivencia. Aunque las mujeres menores de 35 años representan el 3-4% del total de casos diagnosticados, sus tumores se caracterizan por ser más grandes, más proliferativos y con una mayor representación de subtipos más agresivos y de peor pronóstico. Las transformaciones neoplásicas se asocian con alteraciones en la metilación del ADN, que incluyen tanto la hipometilación global como la hipermetilación específica. Por otro lado, los miRNAs son pequeñas moléculas no codificantes con un papel importante en la regulación de …
Development of new strategies to assess the safety of controlled ovarian stimulation for fertility preservation in breast cancer patients
2023
El càncer de mama és la neoplàsia més comuna en dones en edat reproductiva. Les millores en el diagnòstic i el tractament d'aquesta malaltia han suposat un important descens en la mortalitat en els darrers 20 anys. Tot i això, el tractament quimioterapèutic del càncer de mama resulta altament gonadotòxic, sovint danyant la funció ovàrica i implicant una pèrdua de la fertilitat posterior. Per aquest motiu, oferir la possibilitat de preservar la fertilitat en dones amb desitjos reproductius posteriors resulta de vital importància. Entre les opcions per preservar la fertilitat femenina, la criopreservació d'ovòcits i/o embrions destaca com la tècnica amb més èxit a la pràctica clínica habitual…
Letter to the Editor: statistics and clinical perception of patients’ reported outcomes for palbociclib and abemaciclib: a sliding doors story
2023
The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast canc…
2023
Purpose In HER2-positive (HER2 +) breast cancer, tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) may influence the efficacy of the HER2-antibody trastuzumab and the patient’s outcome. In this HER2 + patient cohort, our aim was to study the numbers of FoxP3 + regulatory TILs and CD8 + cytotoxic TILs, their correlations with CD68 + and CD163 + TAMs, and the prognostic and predictive value of the studied factors. Methods We evaluated 139 non-metastatic HER2 + breast cancer patients operated between 2001 and 2008. The FoxP3+TIL count (FoxP3+TILs) was assessed using the hotspot method, and the CD8 + TIL count (CD8+mTILs) utilizing a digital image analysis from invas…
Detection of
2019
Circulating tumor DNA (ctDNA) has emerged as a non-invasive “liquid biopsy” for early breast cancer diagnosis. We evaluated the suitability of ctDNA analysis in the diagnosis of early breast cancer after mammography findings, comparing PIK3CA and TP53 mutations between tumor biopsies and pre-biopsy circulating DNA. Matched plasma and frozen fresh tissue biopsies from patients with Breast Imaging-Reporting and Data System (BIRADS) 4c/5 mammography findings and subsequent diagnosis of primary breast cancer were analyzed using NGS TruSeq Custom Amplicon Low Input Panel (Illumina) and plasma SafeSEQ (Sysmex Inostics). The same plasma and tumor mutations were observed in eight of 29 patients (27…
BRCA1 and BRCA2 germline mutations in sicilian breast and/or ovarian cancer families and their association with familial profiles
2009
Tissue microarray technology in breast cancer subtyping
2008
Work Ability after Breast Cancer: Study of Healthcare Personnel Operating in a Hospital of South Italy
2022
Breast cancer (BrC) treatment can produce disabilities that often impact the quality of daily life and impact the social and working relationships of the patient. This paper looked into the remaining work ability in a group of female healthcare personnel (HCPs) with BrC in Southern Italy. Each HCP was subjected to a medical check, routine blood tests, and a questionnaire on the work ability index (WAI). Of 980 (100%) HCWs undergoing health control, 6% (n = 54) had experienced BRC, and only 66.6% (n = 36) agreed to take part in the study. A total of 28 (78%) were on night shifts. The WAI score was quite low in 5 (13.8%) cases, moderate in 10 (27.7%) cases, good in 14 (38.8%) cases, and excel…