Search results for "BREAST"
showing 10 items of 1871 documents
Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer ste…
2018
Despite marked advancements in its treatment, breast cancer is still the second leading cause of cancer death in women, due to relapses and distal metastases. Breast cancer stem cells (CSCs), are a cellular reservoir for recurrence, metastatic evolution and disease progression, making the development of novel therapeutics that target CSCs, and thereby inhibit metastases, an urgent need. We have previously demonstrated that the cystine-glutamate antiporter xCT (SLC7A11), a protein that was shown to be overexpressed in mammary CSCs and that plays a key role in the maintenance of their redox balance, self-renewal and resistance to chemotherapy, is a potential target for mammary cancer immunoth…
Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on B…
2020
Copyright © 2020 Murugaiah, Agostinis, Varghese, Belmonte, Vieni, Alaql, Alrokayan, Khan, Kaur, Roberts, Madan, Bulla and Kishore. Human surfactant protein D (SP-D) belongs to the family of collectins that is composed of a characteristic amino-terminal collagenous region and a carboxy-terminal C-type lectin domain. Being present at the mucosal surfaces, SP-D acts as is a potent innate immune molecule and offers protection against non-self and altered self-such as pathogens, allergens, and tumour. Here, we examined the effect of a recombinant fragment of human SP-D (rfhSP-D) on a range of breast cancer lines. Breast cancer has four molecular subtypes characterised by varied expression of oes…
Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas
2019
C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent manner. Being a pattern recognition molecule of the innate immunity, C1q can recognize a number of self, non-self and altered-self ligands and bring about effector mechanisms designed to clear pathogens via opsonisation and inflammatory response. C1q is locally synthesized by macrophages and dendritic cells, and thus, can get involved in a range of biological processes, such as angiogenesis and tissue remodeling, immune modulation, and immu…
Can radium 223 be a conservative non-surgical management of medication-related osteonecrosis of the jaw?
2019
AbstractOsteonecrosis of the jaw (ONJ) is a rare and severe necrotic bone disease reflecting a compromise in the body's osseous healing mechanisms and unique to the craniofacial region. Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. In 2018, a Caucasian 54-year-old woman presented to our institution for a breast cancer with bone metastases. Since the patient refused any treatment and taking into account the bone disease, our multidisciplinary team evaluated a supplementary strategy wi…
Breast Cancer-Related Lymphedema: Prevalence, Risk Factors and Surgical Treatment
Effect of cadmium and manganese on gene expression and “in vitro” proliferative and invasive behaviour of MDA-MB231 human breast cancer cells
2009
Prognostic and functional significant of mmp2 and mmp9 in breast cancer unveiled by proteomic analysis
2022
Spousal support and illness acceptance in breast cancer patients: the mediating function of meaning in life and sense of coherence
2023
The explanation as to why married cancer patients are characterised by better adjustment to illness than unmarried patients is not fully understood. This article aims to investigate a parallel mediation effect of meaning in life and sense of coherence in the relationship of spousal support and illness acceptance in breast cancer patients. A total of 213 women were included in this study. The Berlin Social Support Scales, the Personal Meaning Profile, the Sense of Coherence Scale, and the Acceptance of Life with the Disease Scale were used. Pearson’s correlation coefficient and mediation analysis were performed. The results showed significant correlations between spousal support, meaning in…
A fourier-based algorithm for micro-calcification enhancement in mammographic images
2008
Breast cancer is the most widespread cancer in women in the world; it manifests mostly in two forms: microcalcifications and massive lesions. These two forms differ in density, size, shape and number. Consequently, there are two different kinds of mammographic CAD algorithms: those for microcalcifications detection, and those for massive lesions detection. The microcalcifications detection is a hard task, since they are quite small and often poorly contrasted against the background, especially in images affected by digitization noise. In a CAD system the ROI Hunter plays an important role, because missed microcalcifications at this level are definitely lost. For this reason, highlighting me…
SIFT Texture Description for Understanding Breast Ultrasound Images
2014
Texture is a powerful cue for describing structures that show a high degree of similarity in their image intensity patterns. This paper describes the use of Self-Invariant Feature Transform (SIFT), both as low-level and high-level descriptors, applied to differentiate the tissues present in breast US images. For the low-level texture descriptors case, SIFT descriptors are extracted from a regular grid. The high-level texture descriptor is build as a Bag-of-Features (BoF) of SIFT descriptors. Experimental results are provided showing the validity of the proposed approach for describing the tissues in breast US images.