Search results for "BREAST"
showing 10 items of 1871 documents
Male breast cancer.
2010
Male breast cancer (MaleBC) is a rare disease, accounting for <1% of all male tumors. During the last few years, there has been an increase in the incidence of this disease, along with the increase in female breast cancer (FBC). Little is known about the etiology of MaleBC: hormonal, environmental and genetic factors have been reported to be involved in its pathogenesis. Major risk factors include clinical disorders carrying hormonal imbalances, radiation exposure and, in particular, a positive family history (FH) for BC, the latter suggestive of genetic susceptibility. Rare mutations in high-penetrance genes (BRCA1 and BRCA2) confer a high risk of BC development; low-penetrance gene mutati…
Fertility and breast cancer: A literature review of counseling, preservation options and outcomes.
2021
Fertility preservation is an important issue in breast cancer patients undergoing oncological treatment. Fertility counseling is a crucial need given the physical and psychological stress experienced by patients. Cryopreservation of mature oocytes is currently the standard fertility-preserving procedure. Other options such as ovarian tissue preservation or gonadal protection during chemotherapy are still experimental, but have proven effectiveness. Prompt referral to a fertility unit is highly recommended in order to ensure quality of care. In this article, we focus on the different strategies to preserve fertility in breast cancer patients, assessing also the safety of pregnancy and breast…
Determinants of complementary feeding practices in infants from the ELFE study : familial health, socio-economic and demographic characteristics and …
2018
Infant feeding practices could be risk factors for cardiovascular diseases, via early nutritional programming. These practices have not been described in detail in France until now and knowing their determinants could help improve nutritional prevention interventions.For more than 11 000 children followed in the ELFE cohort (French Longitudinal Study since childhood), we calculated the age at introduction of complementary feeding (CFg) and of food groups, evaluated the uses of added sugar, salt and fat from 3 to 10 months old, and defined three principal components of early feeding. Their associations with familial characteristics were evaluated, taking in account the influence of the infan…
Wet-nurses in the ABC newspaper (1903-1920)
2017
espanolEn el proceso de alimentacion infantil a lo largo de la historia una de las opciones ha sido la descarga en las nodrizas tanto a nivel familiar como institucional. Esta figura social se ha reflejado en la prensa y puede ser estudiada en funcion de su representacion. Nos planteamos como objetivo adquirir una vision social a traves del analisis de un corpus de documentos del diario ABC de Madrid entre los anos 1903 a 1920. Metodologicamente se ha recurrido a la revision y analisis de contenido del diario ABC en el periodo indicado de las noticias, anuncios y demas referencias del termino nodriza. Se han recuperado y analizado 999 documentos, que se corresponden al 41% corresponden a of…
Los expósitos y su representación en “La Gazeta de Madrid”
2016
La existencia de diarios oficiales permite a los Estados informar de la actividad legislativa y administrativa. Diferentes estudios han utilizado estos boletines para analizar la información sociosanitaria de un momento histórico determinado. Nos planteamos como objetivo valorar la evolución de las referencias respecto a los expósitos y su relación con las nodrizas en la “Gazeta de Madrid”, permitiendo la categorización en función de los aspectos tratados. Se plantea la revisión y análisis de contenido de las 130 referencias aparecidas entre 1751 y 1926 que cumplían los criterios establecidos. Tras la lectura, transcripción, cumplimentación y categorización de la información recopilada se r…
Myc Promoter-Binding Protein-1 (MBP-1) Is a Novel Potential Prognostic Marker in Invasive Ductal Breast Carcinoma
2010
BackgroundAlpha-enolase is a glycolytic enzyme that catalyses the formation of phosphoenolpyruvate in the cell cytoplasm. α-Enolase and the predominantly nuclear Myc promoter-binding protein-1 (MBP-1) originate from a single gene through the alternative use of translational starting sites. MBP-1 binds to the P2 c-myc promoter and competes with TATA-box binding protein (TBP) to suppress gene transcription. Although several studies have shown an antiproliferative effect of MBP-1 overexpression on several human cancer cells, to date detailed observations of α-enolase and MBP-1 relative expression in primary tumors versus normal tissues and their correlation with clinicopathological features ha…
The differentiation antigen NY-BR-1 is a potential target for antibody-based therapies in breast cancer
2007
Antibody-based cancer immunotherapy relies on the identification and characterization of target antigens and the development of potent antibodies recognizing the target. Here we report the expression analysis and molecular characterization of the differentiation antigen NY-BR-1, which we previously identified by using the SEREX (serological analysis of recombinant cDNA expression libraries) method. Corroborating methodologies, including mRNA quantitation and immunoblotting show that NY-BR-1 is strongly expressed in >70% of 129 breast tumors. Application of a NY-BR-1 specific antibody demonstrated NY-BR-1 expression in primary and metastastic breast cancers. In contrast, most of the breast c…
A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk.
2011
Owing to their role in controlling the efflux of toxic compounds, transporters are central players in the process of detoxification and elimination of xenobiotics, which in turn is related to cancer risk. Among these transporters, ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance protein 2 (MRP2) and ABCG2/breast cancer resistance protein (BCRP) affect susceptibility to many hematopoietic malignancies. The maintenance of regulated expression of these transporters is governed through the activation of intracellular "xenosensors" like the nuclear receptor 1I2/pregnane X receptor (NR1I2/PXR). SNPs in genes encoding these regulators have also been implicate…
Egg consumption and human health: an umbrella review of observational studies
2019
Egg consumption has been an area of controversy regarding its impact on human health largely due to the content in cholesterol and its potential role in cardio-metabolic outcomes. This study aimed to summarise the level of evidence of egg consumption on various health outcomes. A systematic search for meta-analyses was performed: study design, dose-response relationship, heterogeneity and agreement of results over time, and identification of potential confounding factors were considered to assess the level of evidence. Results from this umbrella review showed a substantial no association between egg consumption and a number of health outcomes, including cancer, cardiovascular and metabolic …
A loop involving NRF2, miR‐29b‐1‐5p and AKT, regulates cell fate of MDA‐MB‐231 triple‐negative breast cancer cells
2019
The present study shows that nuclear factor erythroid 2-related factor 2 (NRF2) and miR-29b-1-5p are two opposite forces which could regulate the fate of MDA-MB-231 cells, the most studied triple-negative breast cancer (TNBC) cell line. We show that NRF2 activation stimulates cell growth and markedly reduces reactive oxygen species (ROS) generation, whereas miR-29b-1-5p overexpression increases ROS generation and reduces cell proliferation. Moreover, NRF2 downregulates miR-29b-1-5p expression, whereas miR-29b-1-5p overexpression decreases p-AKT and p-NRF2. Furthermore, miR-29b-1-5p overexpression induces both inhibition of DNA N-methyltransferases (DNMT1, DNMT3A, and DNMT3B) expression and …