Search results for "BT"

showing 10 items of 1498 documents

Mediterranean Diet in patients with acute ischemic stroke: Relationships between Mediterranean Diet score, diagnostic subtype, and stroke severity in…

2015

Abstract Background Adherence to a Mediterranean Diet appears to reduce the risk of cardiovascular disease, cancer, Alzheimer's disease, and Parkinson's disease, as well as the risk of death due to cardiovascular disease. No study has addressed the association between diagnostic subtype of stroke and its severity and adherence to a Mediterranean Diet in subjects with acute ischemic stroke. Aim To evaluate the association between Mediterranean Diet adherence, TOAST subtype, and stroke severity by means of a retrospective study. Methods The type of acute ischemic stroke was classified according to the TOAST criteria. All patients admitted to our ward with acute ischemic stroke completed a 137…

MaleTOAST subtypemedicine.medical_specialtySettore MED/09 - Medicina InternaMediterranean dietPopulationDiseaseDiet MediterraneanSeverity of Illness IndexBrain IschemiaBrain ischemiaMediterranean Diet scoreRisk FactorsSurveys and QuestionnairesInternal medicineSeverity of illnessmedicineHumanscardiovascular diseaseseducationStrokeAgedRetrospective Studieseducation.field_of_studyMediterranean Dietbusiness.industryRetrospective cohort studyMiddle Agedmedicine.diseaseStrokeSSS*Cardiovascular DiseasesPhysical therapyPatient ComplianceRegression AnalysisFemaleCardiology and Cardiovascular MedicinebusinessAtherosclerosis
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Effects of nitric oxide-active drugs on the discharge of subthalamic neurons: microiontophoretic evidence in the rat.

2006

The presence of nitric oxide (NO) synthase and of soluble guanylyl cyclase, the main NO-activated metabolic pathway, has been demonstrated in many cells of the subthalamic nucleus. In this study, the effects induced on the firing of 96 subthalamic neurons by microiontophoretically administering drugs modifying NO neurotransmission were explored in anaesthetized rats. Recorded neurons were classified into regularly and irregularly discharging on the basis of their firing pattern. Nω-nitro-l-arginine methyl ester (L-NAME; a NO synthase inhibitor), 3-morpholino-sydnonimin-hydrocloride (SIN-1; a NO donor), S-nitroso-glutathione (SNOG; another NO donor) and 8-Br-cGMP (a cell-permeable analogue o…

MaleTime FactorsAction PotentialsNeurotransmissionInhibitory postsynaptic potentialNitric OxideSettore BIO/09 - FisiologiaNitric oxideS-Nitrosoglutathionechemistry.chemical_compoundSubthalamic NucleusAnimalsNitric Oxide DonorsEnzyme InhibitorsRats WistarCyclic GMPNeuronsAnalysis of VarianceIontophoresisDose-Response Relationship DrugChemistryGeneral Neuroscience8-Br-cGMP L-NAME SIN-1 SNOG subthalamic nucleusIontophoresisThionucleotidesRatsEnzyme ActivationSubthalamic nucleusNG-Nitroarginine Methyl EsterMolsidomineS-NitrosoglutathioneExcitatory postsynaptic potentialSoluble guanylyl cyclaseNeuroscience
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A multicenter 12-month experience with a new iliac side-branched device for revascularization of hypogastric arteries.

2016

Abstract Objective The aim of this study was to investigate the 1-year safety and efficacy of a new iliac side-branched device (IBD) for revascularization of the hypogastric arteries. Methods Patients receiving the E-liac (Jotec GmbH, Hechingen, Germany) side-branched device at six German vascular centers either as a stand-alone procedure or in combination with abdominal aortic aneurysm exclusion were included in a prospectively created data bank. Collected data were analyzed for baseline characteristics, procedural events, and clinical follow-up; variables included endoleaks, reinterventions, and internal iliac artery (IIA) patency. Results Between January 2012 and January 2015, a total of…

MaleTime FactorsDatabases FactualEndoleakComputed Tomography Angiographymedicine.medical_treatmentBlood Loss Surgical030204 cardiovascular system & hematologyEndovascular aneurysm repair030218 nuclear medicine & medical imaging0302 clinical medicineRisk FactorsGermanyMedicineHospital MortalityAged 80 and overEndovascular ProceduresGraft Occlusion VascularArteriesMiddle AgedCommon iliac arteryInternal iliac arteryAbdominal aortic aneurysmTreatment OutcomeIliac AneurysmFemaleStentsRadiologyCardiology and Cardiovascular Medicinemedicine.medical_specialtyRevascularizationProsthesis DesignPelvis03 medical and health sciencesBlood Vessel Prosthesis ImplantationAneurysmBlood vessel prosthesismedicine.arteryHumansVascular PatencyAgedRetrospective Studiesbusiness.industryExternal iliac arteryAngiography Digital Subtractionmedicine.diseaseSurgeryBlood Vessel ProsthesisFeasibility StudiesSurgerybusinessJournal of vascular surgery
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Single-centre experience and preliminary Results of intravascular ultrasound in endovascular aneurysm repair

2019

Background Intravascular ultrasound (IVUS) has been introduced as diagnostic adjunct to provide new insights into the diagnosis and therapy of vascular disease. Herein, we compared the outcomes of conventional endovascular aneurysm repair (EVAR) and EVAR with IVUS in patients presenting with infrarenal abdominal aortic aneurysm using a propensity-matched cohort. Methods From May 2013 to August 2017, 221 patients were retrospectively analyzed. Of that, 122 patients were eligible for inclusion and underwent propensity score matching. Perioperative mortality and morbidity, renal function impairment, endoleak incidence, mean contrast medium usage, operative time, radiation exposure (including f…

MaleTime Factorsmedicine.medical_treatmentContrast MediaPredictive Value of TestEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareAortic aneurysmRetrospective StudieRisk FactorsIntravascular ultrasoundFluoroscopyAged 80 and overmedicine.diagnostic_testEndovascular ProceduresGeneral MedicineMiddle AgedRadiation ExposureAbdominal aortic aneurysm2746 SurgeryTreatment OutcomeItalyFemaleRadiologyCardiology and Cardiovascular Medicinerenal function impairmentHumanPreliminary Datamedicine.medical_specialtyTime Factor610 Medicine & healthRadiation DosageAortography2705 Cardiology and Cardiovascular Medicineintravascular ultrasoundBlood Vessel Prosthesis ImplantationEndovascular aneurysm repaircontrast mediumPredictive Value of Testsmedicinefluoroscopy timeHumansUltrasonography InterventionalAgedRetrospective StudiesEndovascular Procedurebusiness.industryRisk FactorAngiography Digital SubtractionPerioperativeDigital subtraction angiographymedicine.disease10020 Clinic for Cardiac SurgeryAngiographySurgerybusinessAortic Aneurysm Abdominal
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Local Delivery of Nimodipine by Prolonged-Release Microparticles—Feasibility, Effectiveness and Dose-Finding in Experimental Subarachnoid Hemorrhage

2012

Background and purposeTo investigate the effect of locally applied nimodipine prolonged-release microparticles on angiographic vasospasm and secondary brain injury after experimental subarachnoid hemorrhage (SAH).Methods70 male Wistar rats were categorized into three groups: 1) sham operated animals (control), 2) animals with SAH only (control) and the 3) treatment group. SAH was induced using the double hemorrhage model. The treatment group received different concentrations (20%, 30% or 40%) of nimodipine microparticles. Angiographic vasospasm was assessed 5 days later using digital subtraction angiography (DSA). Histological analysis of frozen sections was performed using H&E-staining as …

MaleVasodilator AgentsGene ExpressionPolylactic Acid-Polyglycolic Acid CopolymerVasospasm IntracranialDrug DistributionMultidisciplinarymedicine.diagnostic_testMicrofilament ProteinsQRBrainIntracranial ArteryVasospasmAnimal ModelsImmunohistochemistryHemorrhagic StrokeNeurologyAnesthesiaInjections IntravenousToxicityMedicinemedicine.symptomMicrotubule-Associated ProteinsResearch Articlemedicine.drugDrugs and DevicesDrug Research and DevelopmentSubarachnoid hemorrhageCerebrovascular DiseasesScienceNeurosurgeryBrain damageDrug Administration ScheduleModel OrganismsmedicineAnimalsPharmacokineticsLactic Acidcardiovascular diseasesRats WistarBiologyNimodipineDose-Response Relationship Drugbusiness.industryCalcium-Binding ProteinsAngiography Digital SubtractionDigital subtraction angiographySubarachnoid Hemorrhagemedicine.diseaseRatsnervous system diseasesDelayed-Action PreparationsAngiographyRatNimodipineSurgerybusinessPolyglycolic AcidPLoS ONE
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2011–12 Seasonal Influenza Vaccines Effectiveness against Confirmed A(H3N2) Influenza Hospitalisation: Pooled Analysis from a European Network of Hos…

2013

BackgroundInfluenza vaccination strategies aim at protecting high-risk population from severe outcomes. Estimating the effectiveness of seasonal vaccines against influenza related hospitalisation is important to guide these strategies. Large sample size is needed to have precise estimate of influenza vaccine effectiveness (IVE) against severe outcomes. We assessed the feasibility of measuring seasonal IVE against hospitalisation with laboratory confirmed influenza through a network of 21 hospitals in the European Union.MethodsWe conducted a multicentre study in France (seven hospitals), Italy (one hospital), and Navarra (four hospitals) and Valencia (nine hospitals) regions in Spain. All ≥1…

MaleViral DiseasesEpidemiologyPilot ProjectsLogistic regressionmedicine.disease_cause0302 clinical medicineInfluenza A virusClinical Epidemiology030212 general & internal medicineEpidemiological Methodsmedia_commonAged 80 and overeducation.field_of_studyVaccinesMultidisciplinaryQVaccinationREpidemiology of AgingMiddle Aged3. Good healthVaccinationHospitalizationInfectious DiseasesInfluenza VaccinesMedicineFemaleSeasonsResearch ArticleAdultmedicine.medical_specialtyAdolescentInfluenza vaccineClinical Research DesignScience030231 tropical medicinePopulationMicrobiologyHistory 21st CenturyInfectious Disease Epidemiology03 medical and health sciencesYoung AdultInternal medicineVirologyVaccine DevelopmentInfluenza Humanmedicinemedia_common.cataloged_instanceHumansEuropean UnionEuropean unioneducationBiologyAgedbusiness.industryInfluenza A Virus H3N2 SubtypeCase-control studyImmunityViral VaccinesInfluenzaSample size determinationCase-Control StudiesImmunologyClinical ImmunologybusinessPLoS ONE
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Sociodemographic Factors and Clinical Conditions Associated to Hospitalization in Influenza A (H1N1) 2009 Virus Infected Patients in Spain, 2009–2010

2012

The emergence and pandemic spread of a new strain of influenza A (H1N1) virus in 2009 resulted in a serious alarm in clinical and public health services all over the world. One distinguishing feature of this new influenza pandemic was the different profile of hospitalized patients compared to those from traditional seasonal influenza infections. Our goal was to analyze sociodemographic and clinical factors associated to hospitalization following infection by influenza A(H1N1) virus. We report the results of a Spanish nationwide study with laboratory confirmed infection by the new pandemic virus in a case-control design based on hospitalized patients. The main risk factors for hospitalizatio…

MaleViral DiseasesPediatricsNon-Clinical MedicinePulmonologyEpidemiology:Named Groups::Persons::Age Groups::Adult::Aged::Aged 80 and over [Medical Subject Headings]Grip A (H1N1):Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]DiseaseSocial and Behavioral Sciencesmedicine.disease_cause:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]Hospital patients:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Influenza A Virus H1N1 SubtypeGripe humanaSociologyRisk FactorsPandemicInfluenza A virusChildAged 80 and over:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]:Organisms::Viruses::Vertebrate Viruses::RNA Viruses::Orthomyxoviridae::Influenzavirus A::Influenza A virus::Influenza A Virus H1N1 Subtype [Medical Subject Headings]COPDeducation.field_of_studyMultidisciplinary:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]QRMiddle AgedHospitalizationInfectious Diseases:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization [Medical Subject Headings]Child Preschool:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]MedicineFemalePublic Health:Named Groups::Persons::Age Groups::Infant [Medical Subject Headings]Assistència hospitalàriaResearch ArticleAdultmedicine.medical_specialtyAdolescent:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]SciencePopulationHospitals -- Pacients:Check Tags::Male [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]InfluenzavirusVirusYoung AdultInfluenza HumanSubtipo H1N1 del Virus de la Influenza A:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineInfluenza virusesHumansEpidemiologia -- Investigació -- EspanyaEspanyaEpidemiologiaeducationPandemicsBiology:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]AgedHospital carePopulation Biologybusiness.industryPublic healthInfant NewbornCase-control studyInfant:Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics [Medical Subject Headings]medicine.disease:Check Tags::Female [Medical Subject Headings]SpainCase-Control StudiesH1N1 influenza:Diseases::Virus Diseases::RNA Virus Infections::Orthomyxoviridae Infections::Influenza Human [Medical Subject Headings]businessPLoS ONE
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A basal ganglia-like cortical-amygdalar-hypothalamic network mediates feeding behavior.

2020

International audience; The network connecting the insular cortex, the central nucleus of the amygdala, and a caudal hypothalamic nuclear complex including the parasubthalamic nucleus (PSTN) is of interest due to its role in controlling feeding behavior. Here, we show that the organization of this network is similar to that of the basal ganglia network, implying that both fit within a simplified structural plan of the forebrain. Then, we demonstrate that the PSTN complex modulates behavior in response to hedonic factors normally inducing a “reward effect.” The PSTN complex is involved in a “non-feed” response equivalent of a “non-reward” evaluation: “I don’t want to consume this food, recog…

Malecentral amygdala nucleusLateral hypothalamusHypothalamusBiologyInsular cortexIndirect pathway of movementAmygdalaBasal GangliaRats Sprague-Dawley03 medical and health sciencesMice0302 clinical medicineSubthalamic NucleusBasal gangliaNeural PathwaysmedicineAnimals030304 developmental biologyCerebral CortexNeurons0303 health sciencesMultidisciplinary[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behaviorBehavior AnimalCentral nucleus of the amygdalaCentral Amygdaloid NucleusFeeding BehaviorBiological SciencesRatsSubthalamic nucleusmedicine.anatomical_structureOlfactory CortexHypothalamusinsular cortexModels Animal[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC][SDV.AEN]Life Sciences [q-bio]/Food and NutritionNeuroscience030217 neurology & neurosurgeryProceedings of the National Academy of Sciences of the United States of America
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The Factors Affecting Expansion of Reactive Tumor Infiltrating Lymphocytes (TIL) From Bladder Cancer and Potential Therapeutic Applications

2021

Tumor infiltrating lymphocytes (TIL) therapy was shown to provide durable objective response in patients with metastatic melanoma. As a fundamental first step to bring TIL therapy to clinical use, identification of patients whose tumors yield optimal numbers of reactive TIL is indispensable. We have previously shown that expansion of tumor reactive TIL from primary bladder tumors and lymph node metastases is feasible. Here, we performed TIL harvesting from additional surgical specimens (additional 31 primary tumors and 10 lymph nodes) to generate a heterogenous cohort of 53 patients with bladder cancer (BC) to evaluate the tumor characteristics that lead to tumor-reactive TIL expansion. Amo…

Malelcsh:Immunologic diseases. AllergyCD3Immunologychemical and pharmacologic phenomenaBacillus Calmette–GuerinLymphocyte ActivationCancer VaccinesImmunotherapy AdoptiveCohort StudiesBasal (phylogenetics)Tumor Necrosis Factor Receptor Superfamily Member 9Lymphocytes Tumor-InfiltratingmedicineImmunology and AllergyHumansadoptive cellular immunotherapyLymph nodeCells CulturedAgedCell ProliferationOriginal Researchmolecular subtypesBladder cancerbiologyTumor-infiltrating lymphocytesbusiness.industryhemic and immune systemsMiddle Agedmedicine.diseaseMycobacterium bovismedicine.anatomical_structureUrinary Bladder NeoplasmsLymphatic Metastasistumor-infiltrating lymphocytesCancer researchbiology.proteinInterleukin-2bladder cancerFemaleLymphAntibodyUrotheliumbusinesslcsh:RC581-607CD8Frontiers in Immunology
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Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors

2012

The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis.A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used.The mean age was 38.5 years (SD 22.…

Malemedicine.disease_causeInfluenza A Virus H1N1 SubtypepreventionPregnancyInfluenza A virusPharmacology (medical)Young adultChildOriginal ResearchAged 80 and overNeuraminidase inhibitorbiologyMiddle AgedPrognosisHospitalizationInfectious DiseasesChild PreschoolFemaleMicrobiology (medical)Adultmedicine.medical_specialtyAdolescentCritical Caremedicine.drug_classNeuraminidaseadverse outcomesAntiviral AgentsYoung Adultlength of stayInternal medicineDiabetes mellitusIntensive careInfluenza HumanmedicineHumansSurvival analysisAgedPharmacologyPregnancyflubusiness.industrypandemicInfant NewbornInfantLength of Staymedicine.diseaseSurvival AnalysisSpainImmunologybiology.proteinbusinessNeuraminidase
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