Search results for "Bacteriòfags"

showing 2 items of 2 documents

Comparison of CRISPR and Marker-Based Methods for the Engineering of Phage T7

2020

This article belongs to the Section Bacterial Viruses.

0301 basic medicineGenetic Markersviruses030106 microbiologyMutantlcsh:QR1-502t7Computational biologyGenome ViralBiologyGenomeArticlelcsh:MicrobiologyBacteriophage03 medical and health sciencesbacteriophageVirologyBacteriophage T7CRISPRClustered Regularly Interspaced Short Palindromic RepeatsGenomescrisprBacteriophageGeneSelection (genetic algorithm)Gene EditingQHT7Viral Tail Proteinsbiology.organism_classificationBacteriòfags3. Good healthQRtail fibres030104 developmental biologyInfectious DiseasesLytic cycleCRISPRMutationTail fibresCRISPR-Cas SystemsHomologous recombinationGenèticaViruses
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Virus-Host Coevolution as a Tool for Controlling Bacterial Resistance to Phage Therapy

2019

Bacterial resistance to antibiotics is a global public health concern. New treatments are needed to combat resistant strains, among which phage therapy is a promising option. Probably the main advantages of phage therapy are its high specificity as well as rapid viral adaptability, which in principle allows using phage evolution to overcome resistance. Here, we have performed serial coevolution passages between Escherichia coli and its phage T7 to investigate the ability of coevolved phages to reduce the emergence of resistances. We find that the initial bacterial population is less likely to undergo resistance when challenged with experimentally coevolved phages than when challenged with t…

Virus hostPhage therapymedicine.drug_classmedicine.medical_treatmentvirusesAntibioticsBacterial populationBiologyBacteriòfagsMicrobiologyAntibiotic resistanceBacteris patògensmedicineCoevolution
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