Search results for "Bambuterol"

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The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans.

2017

Hypoxemia can be life-threatening, both acutely and chronically. Because hypoxemia causes vascular dysregulation that further restricts oxygen availability to tissue, it can be pharmacologically addressed. We hypothesized that theophylline can be safely combined with the β2-adrenergic vasodilator bambuterol to improve oxygen availability in hypoxemic patients. Ergogenicity and hemodynamic effects of bambuterol and theophylline were measured in rats under hypobaric and normobaric hypoxia (12% O2). Feasibility in humans was assessed using randomized, double-blind testing of the influence of combined slow-release theophylline (300 mg) and bambuterol (20 mg) on adverse events (AEs), plasma K+,…

AdultMaleCombination therapyPhysiologyAdrenergicBiological Availability030204 cardiovascular system & hematologyPharmacologyHypoxemia03 medical and health sciencesYoung Adult0302 clinical medicineTheophyllinePhysiology (medical)Physical Conditioning AnimalmedicineTerbutalineAnimalsHumansTheophyllineDrug InteractionsBambuterolHypoxiaPharmacologybusiness.industryHemodynamicsGeneral MedicineDrug interactionHypoxia (medical)RatsBlood pressureTreatment OutcomeAnesthesiaFemalemedicine.symptomSafetybusiness030217 neurology & neurosurgerymedicine.drugHalf-LifeCanadian journal of physiology and pharmacology
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Safety of combined bambuterol and theophylline as a potential treatment of high altitude‐induced fatigue in humans

2016

business.industryGeneticsmedicineTheophyllineBambuterolPharmacologyEffects of high altitude on humansbusinessMolecular BiologyBiochemistryBiotechnologymedicine.drugThe FASEB Journal
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