Search results for "Base"
showing 10 items of 8362 documents
Synthesis, characterization of diorganotin(IV) complexes of N-(2-hydroxyarylidene)aminoacetic acid and antitumour screening in vivo in ehrlich ascite…
2001
Some new diorganotin(IV) complexes have been prepared by reacting potassium N-(2-hydroxyarylidene)aminoacetate with R2SnCl2(R = Me,nBu,Ph). The complexes have been characterized by 1H,13C,119Sn NMR, IR and 119mSn Mössbauer spectroscopic techniques in combination with elemental analysis. In the solid state, the complexes possess penta- and hexa-coordinated tin centres. The hexa-coordinated tin complexes were found to dissociate in solution, giving rise to penta-coordinated species as revealed by 119Sn NMR spectroscopy. Antitumour screening in vivo of the complexes L4snPh2,L4SnPh2· Ph3SnCl and L4SntBU2·t Bu2SnCl2 (L4 = N-(2-hydroxyacetophenone)aminoacetate) is also reported. Copyright © 2001 …
FORMAL CONCEPTION OF ROUGH SETS
1996
In the paper we present a formal description of rough sets within the framework of the generalized set theory, which is interpreted in the set approximation theory. The rough sets are interpreted as approximations, which are defined by means of the Pawlak's rough sets.
Proving convexity preserving properties of interpolatory subdivision schemes through reconstruction operators
2013
We introduce a new approach towards proving convexity preserving properties for interpolatory subdivision schemes. Our approach is based on the relation between subdivision schemes and prediction operators within Harten's framework for multiresolution, and hinges on certain convexity properties of the reconstruction operator associated to prediction. Our results allow us to recover certain known results [10,8,1,7]. In addition, we are able to determine the necessary conditions for convexity preservation of the family of subdivision schemes based on the Hermite interpolation considered in [4].
Closedness properties in team learning of recursive functions
1997
This paper investigates closedness properties in relation with team learning of total recursive functions. One of the first problems solved for any new identification types is the following: “Does the identifiability of classes U1 and U2 imply the identifiability of U1∪U2?” In this paper we are interested in a more general question: “Does the identifiability of every union of n−1 classes out of U1,...,Un imply the identifiability of U1∪...∪Un?” If the answer is positive, we call such identification type n-closed. We show that n-closedness can be equivalently formulated in terms of team learning. After that we find for which n team identification in the limit and team finite identification t…
Elementary Action Systems
2015
This chapter expounds basic notions. An elementary action system is a triple consisting of the set of states, the transition relation between states, and a family of binary relations defined on the set of states. The elements of this family are called atomic actions. Each pair of states belonging to an atomic action is a possible performance of this action. This purely extensional understanding of atomic actions is close to dynamic logic. Compound actions are defined as sets of finite sequences of atomic actions. Thus compound actions are regarded as languages over the alphabet whose elements are atomic actions. This chapter is concerned with the problem of performability of actions and the…
Learning from good examples
1995
The usual information in inductive inference for the purposes of learning an unknown recursive function f is the set of all input /output examples (n,f(n)), n ∈ ℕ. In contrast to this approach we show that it is considerably more powerful to work with finite sets of “good” examples even when these good examples are required to be effectively computable. The influence of the underlying numberings, with respect to which the learning problem has to be solved, to the capabilities of inference from good examples is also investigated. It turns out that nonstandard numberings can be much more powerful than Godel numberings.
On the Estimation of the Volatility-Growth Link
2012
It is common practice to estimate the volatility-growth link by specifying a standard growth equation such that the variance of the error term appears as an explanatory variable in this growth equation. The variance in turn is modeled by a second equation. Hardly any of existing applications of this framework includes exogenous controls in this second variance equation. Our theoretical findings suggest that the absence of relevant explanatory variables in the variance equation leads to a biased and inconsistent estimate of the volatility-growth link. Our simulations show that this effect is large. Once the appropriate controls are included in the variance equation consistency is restored. I…
Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms
1998
Abstract Transgenic systems, both cell lines and mice with gain or loss of function, are being used in order to modulate the expression of DNA repair proteins, thus allowing to assess their contribution to the defense against genotoxic mutagens and carcinogens. In this review, questions have been addressed concerning the use of transgenic systems in elucidating critical primary DNA lesions, their conversion into genotoxic endpoints, low-dose effects, and the relative contribution of individual cellular functions in defense. It has been shown that the repair protein alkyltransferase (MGMT) is decisive for protection against methylating and chloroethylating compounds. Protection pertains also…
Human Monocytes, but not Dendritic Cells Derived from Them, Are Defective in Base Excision Repair and Hypersensitive to Methylating Agents
2007
Abstract Monocytes and dendritic cells are key players in the immune response. Because dendritic cells drive the tumor host defense, it is important that monocytes and dendritic cells survive cytotoxic tumor therapy. Although most of the anticancer drugs target DNA, the DNA repair capacity of monocytes and dendritic cells has not yet been investigated. We studied the sensitivity of monocytes and monocyte-derived dendritic cells against various genotoxic agents and found monocytes to be more sensitive to overall cell kill and apoptosis upon exposure to methylating agents (e.g., N-methyl-N′-nitro-N-nitrosoguanidine, methyl methanesulfonate, and the anticancer drug temozolomide). On the other …
MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents
2007
O(6)-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense against alkylating agents that generate, among other lesions, O(6)-alkylguanine in DNA (collectively termed O(6)-alkylating agents [O(6)AA]). The defense is highly important, since O(6)AA are common environmental carcinogens, are formed endogenously during normal cellular metabolism and possibly inflammation, and are being used in cancer therapy. O(6)AA induced DNA damage is subject to repair, which is executed by MGMT, AlkB homologous proteins (ABH) and base excision repair (BER). Although this review focuses on MGMT, the mechanism of repair by ABH and BER will also be discussed. Experimental systems, in wh…