Search results for "Bax"
showing 10 items of 25 documents
BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival.
2015
The endoplasmic reticulum (ER) serves as the major intracellular Ca(2+) store and has a role in the synthesis and folding of proteins. BAX (BCL2-associated X protein) inhibitor-1 (BI-1) is a Ca(2+) leak channel also implicated in the response against protein misfolding, thereby connecting the Ca(2+) store and protein-folding functions of the ER. We found that BI-1-deficient mice suffer from leukopenia and erythrocytosis, have an increased number of splenic marginal zone B cells and higher abundance and nuclear translocation of NF-κB (nuclear factor-κ light-chain enhancer of activated B cells) proteins, correlating with increased cytosolic and ER Ca(2+) levels. When put into culture, purifie…
Mcl-1 and Bok transmembrane domains : Unexpected players in the modulation of apoptosis
2020
The Bcl-2 protein family comprises both proand antiapoptotic members that control the permeabilization of the mitochondrial outer membrane, a crucial step in the modulation of apoptosis. Recent research has demonstrated that the carboxyl-terminal transmembrane domain (TMD) of some Bcl-2 protein family mem-bers can modulate apoptosis; however, the transmembrane interactome of the antiapoptotic protein Mcl-1 remains largely unexplored. Here, we demonstrate that the Mcl-1 TMD forms homooligomers in the mitochondrial membrane, competes with full-length Mcl-1 protein with regards to its antiapoptotic function, and induces cell death in a Bok-dependent manner. While the Bok TMD oligomers locate p…
Left Braces and the Yang-Baxter Equation
2021
L’equació quàntica de Yang-Baxter (YBE per les seues inicials en anglès) és una equació important en la física matemàtica introduïda per Yang en 1967. Un dels seus principals problemes oberts és trobar-ne totes les solucions. En 1992, Drinfeld va definir un subtipus de solucions, les conjuntistes, i va proposar el problema de trobar-les totes. Recentment, una subclasse de les solucions conjuntistes ha sigut molt estudiada: les involutives i no degenerades (a partir d’ara, les anomenarem simplement solucions). En 2007, Rump va introduir una nova estructura algebraica, les brides a esquerra, per a estudiar aquestes solucions, i va demostrar que cada brida a esquerra té una solució de la YBE a…
Bcl-2 as prognostic factor in head and neck squamous cell carcinoma
2005
A series of 66 cases of oral squamous cell carcinoma (OSCC) was retrospectively analyzed by immunohisto-chemistry for bcl-2 expression to verify its predictive value for clinical outcome in patients with OSCC. After grouping for bcl-2 expression, OSCCs were statistically analyzed for the variables age, gender, histological grading (G), TNM, staging, recurrence, and overall survival rate. Univariate and multivariate (Cox regression) analyses were performed. Thirty-six OSCC (54.5%) showed expression for bcl-2, whereas 30 (44.5%) were negative. No statistical association was found between bcl-2 expression and any variables considered at baseline. Overall disease-specific survival rate at 72 mo…
Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells.
2011
SUMMARYAlthough many cancer cells are primed for apoptosis, they usually develop resistance to cell death at multiple levels. Permeabilization of the outer mitochondrial membrane, which is mediated by proapoptotic Bcl-2 family members like Bax, is considered as a point-of-no-return for initiating apoptotic cell death. This crucial role has placed Bcl-2 family proteins as recurrent targets for anticancer drug development. Here, we propose and demonstrate a new concept based on using minimal active version of Bax to induce cell death independently of endogenous Bcl-2 proteins. We show that membrane-active segments of Bax can directly induce the release of mitochondria-residing apoptogenic fac…
Left braces and the quantum Yang-Baxter equation
2019
[EN] Braces were introduced by Rump in 2007 as a useful tool in the study of the set-theoretic solutions of the Yang¿Baxter equation. In fact, several aspects of the theory of finite left braces and their applications in the context of the Yang¿Baxter equation have been extensively investigated recently. The main aim of this paper is to introduce and study two finite brace theoretical properties associated with nilpotency, and to analyse their impact on the finite solutions of the Yang¿Baxter equation.
L'ANTICO CAMPANILE DELLA CATTEDRALE DI LECCE IN UN CONSULTO DEL 1574
2016
L'antico campanile della cattedrale di Lecce si trovava in una posizione diversa rispetto a quello esistente costruito nel 1658. La maestosa torre, con cinque ordini e una terminazione a corona, era collocata di fianco all'antica facciata principale della chiesa, sul lato sinistro. Nel 1574 a causa di numerosi crolli, gli amministratori della chiesa decisero di avvalersi del parere tecnico di tre professionisti: Padoano Schiero, Padoano Baxi e Gabriele Meschinello, chiamati ad esprimersi in merito alla pericolosità di tali crolli e allo stato della torre. Vennero prodotte tre relazioni tecniche i cui contenuti illustravano la necessità di demolire la torre al fine di scongiurare eventuali d…
The evaluation of changes in maxillofacial bones using cone beam tomography in acromegaly
2022
BACKGROUND: The aim of the study was to evaluate the changes in craniofacial dimensions of newly diagnosed and untreated acromegaly patients, patients with non-functional pituitary adenoma and healthy individuals on Cone Beam Computed Tomography (CBCT). MATERIAL AND METHODS: 50 newly diagnosed acromegaly patients who did not receive any treatment for acromegaly were included in the study (Group A). Twenty patients with nonfunctional pituitary adenoma (Group B) and 30 healthy individuals were included (Group C). Linear, angular and volumetric measurements were performed. RESULTS: Mandibular length showed significant difference in acromegaly patients, and maxillar length statistically signifi…
The Structure Group and the Permutation Group of a Set-Theoretic Solution of the Quantum Yang–Baxter Equation
2021
We describe the left brace structure of the structure group and the permutation group associated to an involutive, non-degenerate set-theoretic solution of the quantum YangBaxter equation by using the Cayley graph of its permutation group with respect to its natural generating system. We use our descriptions of the additions in both braces to obtain new properties of the structure and the permutation groups and to recover some known properties of these groups in a more transparent way.
Prognostic Value of p53, p21/WAF1, Bcl-2, Bax, Bak and Ki-67 Immunoreactivity in pT1 G3 Urothelial Bladder Carcinomas
2001
pT1 G3 bladder carcinomas are heterogeneous with respect to tumor recurrence and progression. Whereas some urologists treat these carcinomas by repeated transurethral resections often followed by intravesical chemotherapy or BCG instillation, others recommend cystectomy after tumor recurrence or early cystectomy after the initial diagnosis. Our goal was to determine the prognostic value of p53, p21/WAF1, Bcl-2, Bax, Bak, and Ki-67 immunoreactivity in these tumors. There were 30 patients with a new histopathological diagnosis of pT1 G3 urothelial carcinoma based on a transurethral resection specimen. Representative sections of these specimens were examined for the above markers. All patients…