Search results for "Benign"
showing 10 items of 185 documents
Solitary Necrotic Nodule of the Liver: Different Pathological Findings Express a Different Histogenesis
2008
Solitary necrotic nodule of the liver is a rare benign lesion the histogenesis of which is still debated. We here report the case of a patient who underwent laparoscopic cholecystectomy for gallstones and who was accidentally found to have a solitary necrotic nodule of 2 cm in the fifth segment of the liver. On the basis of the histological findings, the hypothesis that different pathogenetic mechanisms could be involved in the histogenesis of this lesion is discussed.
OR18-01 Effect of Teprotumumab on Proptosis Reduction Across Various Demographic Sub-Groups
2020
Abstract Introduction: Teprotumumab, an insulin-like growth factor 1 receptor inhibitory monoclonal antibody, was recently shown to significantly reduce proptosis in patients with active, moderate-to-severe thyroid eye disease (TED) in phase 2 and phase 3 clinical trials.1,2 Prior analyses have demonstrated a combined trial proptosis response (≥2 mm reduction) rate of 77.4% in the teprotumumab group and 14.9% in the placebo group after 24 weeks of therapy (p < 0.001).3 The current analysis was performed to investigate whether or not patient demographic characteristics influence the teprotumumab proptosis response. Methods: Data from two 24-week randomized, double-masked, placebo-cont…
SAT-429 Systemic Safety Analysis of Mycophenolate in Graves’ Orbitopathy
2020
Abstract Context The dual antiproliferative mechanism of mycophenolate appears to be beneficial in Graves’ orbitopathy (GO). Methods The safety data, which is of utmost importance in immunomodulation, from the two major randomized mycophenolate trials [“Chinese trial” (1) and “European Group on Graves’ Orbitopathy (EUGOGO) trial” (2)] and the original database of the EUGOGO trial were systematically analyzed. Treatment efficacy stratified by individual visual parameters of clinical disease activity and severity were also compared. Results A total of 129 adverse events (AE) involving 50 patients (29.4%) were noted among all mycophenolate-treated patients. Mycophenolate sodium plus intravenou…
Towards to deep neural network application with limited training data: synthesis of melanoma's diffuse reflectance spectral images
2019
The goal of our study is to train artificial neural networks (ANN) using multispectral images of melanoma. Since the number of multispectral images of melanomas is limited, we offer to synthesize them from multispectral images of benign skin lesions. We used the previously created melanoma diagnostic criterion p'. This criterion is calculated from multispectral images of skin lesions captured under 526nm, 663nm, and 964nm LED illumination. We synthesize these three images from multispectral images of nevus so that the p' map matches the melanoma criteria (the values in the lesion area is >1, respectively). Demonstrated results show that by transforming multispectral images of benign nevus i…
Tufted angiomas in childhood: A series of 9 cases and a literature review
2015
Introduction: Tufted angioma (TA) is a rare benign vascular tumour that mostly appears during infancy or early childhood, although there are cases reported in adults. Clinical presentation and evolution of TA can vary. Histologically, it takes on a classic appearance of vascular tufts (“cannon ball” like appearance). Patients and methods: A retrospective observational study was conducted that included all patients diagnosed with TA at our centre in the last 20 years. Results: A series of 9 cases of tufted angioma in childhood are presented, 77.7% of which were congenital. This represents a frequency higher than previously described. Spontaneous regression was observed in 55.5% of the cases,…
Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: prognostic significance.
2000
TP53 and MDM2 genes and their protein expression were evaluated in frozen and paraffin-embedded tissue from 27 patients with malignant fibrous histiocytoma to elucidate the relationship between them, their implication in tumor progression mechanisms and their possible diagnostic-prognostic value in malignant fibrous histiocytoma. Single-strand conformation polymorphism analysis and direct sequencing of polymerase chain reaction-amplified DNA were used to establish two TP53 mutations (7.4%): a point mutation and a 63-bp duplication. Amplification of the MDM2 gene was observed in two tumors (7.4%) by means of Southern-blot analysis, one of them also carrying the TP53 point mutation. Immunohis…
LE NEOPLASIE CISTICHE BENIGNE DEL TESTICOLO IN ETA' PEDIATRICA: revisione della letteratura, contributo clinico personale e nuove proposte terapeutic…
1990
Gli Autori ribadiscono l'importanza dell'approccio multisciplinare alle masse del testicolo e sottolineano il corretto atteggiamento terapeutico, sulla base della revisione della letteratura e dopo valutazione dei dati di una casistica nazionale
Uncommon evolutions and complications of common benign liver lesions
2018
International audience; Frequently encountered on abdominal imaging studies, the majority of common benign liver lesions are asymptomatic, confidently diagnosed by imaging, and do not require further workup, follow-up, or treatment. The increasing use of multimodality liver imaging, has allowed the recognition of uncommon evolutions of common benign liver lesions such as size changes, fibrotic regression, and content and vascularization changes, and their complications such as rupture, hemorrhage, thrombosis, extrinsic compression, and malignancy. The purpose of this pictorial review is to describe and illustrate the incidence and diagnostic features of these uncommon evolutions and complic…
uso degli alfa-bloccanti nell'ipertrofia prostatica benigna: il problema della "floppy iris syndrome". Risultati di uno studio caso-controllo per la …
2009
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Infantile Hemangioma Detection using Deep Learning
2020
Infantile hemangiomas are the most common type of benign tumor which appear in the first weeks of life. As currently there is no robust protocol to monitor and assess the hemangioma status, this study proposes a preliminary method to detect the lesion. Therefore, in this paper we describe a hemangiomas classifier based on a linear convolutional neural network architecture. The challenge was to achieve a good classification using a relatively small internal database of 240 images from 40 different patients. The results are promising as the CNN performance evaluation showed a level of accuracy on the test set of 93.84%. Five metrics were calculated to assess the proposed model performances: a…