Search results for "Benzamide"

showing 10 items of 199 documents

The effects of enzalutamide and abiraterone on skeletal related events and bone radiological progression free survival in castration resistant prosta…

2017

Two new drugs, the CYP17 inhibitor abiraterone acetate and the androgen receptor (AR) antagonist enzalutamide, have recently shown to prolong OS prior chemotherapy or in docetaxel treated mCRPC patients, using steroidal therapy or placebo as control group. Updated analyses underlined the role of these new agents on two prostate-specific endpoints as radiographic progression-free survival (rPFS) and time to first skeletal-related event (tSRE). On the basis of these reports, we made an indirect comparison between abiraterone and enzalutamide. We obtained a clinically but not significant difference favouring enzalutamide over abiraterone in terms of rPFS (HR 0.48, 95% CI 0.22–1.02). No signi…

Malemedicine.medical_specialtySettore MED/06 - Oncologia Medicamedicine.medical_treatmentUrologyAbiraterone AcetateBone NeoplasmsAbiraterone; Enzalutamide; mCRPC; rPFS; tSRE; Hematology; Oncology; Geriatrics and GerontologyPlaceboDisease-Free Survivallaw.invention03 medical and health scienceschemistry.chemical_compoundProstate cancer0302 clinical medicineRandomized controlled triallawNitrilesPhenylthiohydantoinEnzalutamideAndrogen Receptor AntagonistsMedicineEnzalutamideCytochrome P-450 Enzyme InhibitorsHumans030212 general & internal medicineProgression-free survivalAbirateronetSRERandomized Controlled Trials as TopicChemotherapybusiness.industryAbiraterone acetateHematologymCRPCmedicine.diseaseProstatic Neoplasms Castration-ResistantTreatment OutcomechemistryDocetaxelrPFSOncology030220 oncology & carcinogenesisBenzamidesDisease ProgressionGeriatrics and Gerontologybusinessmedicine.drugCritical reviews in oncology/hematology
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Hockey-Puck micelles from oligo(p-benzamide)-b-PEG rod-coil block copolymers.

2006

Materials sciencesportsGeneral ChemistryMicelleCatalysischemistry.chemical_compoundScanning probe microscopyCrystallographyHockey puckchemistryElectromagnetic coilPEG ratiosports.equipmentCopolymerBenzamideAngewandte Chemie (International ed. in English)
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Analytical method for simultaneous determination of pesticide and veterinary drug residues in milk by CE-MS

2009

10 páginas, 2 figuras, 4 tablas.

Maximum Residue LimitVeterinary drugsClinical BiochemistryPirimicarbBiochemistryAnalytical Chemistrychemistry.chemical_compoundTandem Mass SpectrometrySulfaquinoxalineCE-MS/MSmedicineAnimalsVeterinary drugPesticidesChromatographyPesticide residueChemistryPesticide ResiduesSulfabenzamideElectrophoresis CapillaryPesticideDrug ResiduesMilkFoodProcymidonemedicine.drug
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Gold(ii) in redox-switchable gold(i) catalysis

2019

Chemical communications 55(32), 4615 - 4618 (2019). doi:10.1039/C9CC00283A

Metals and AlloysHalideGeneral Chemistry540Combinatorial chemistryRedoxCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCatalysischemistry.chemical_compoundchemistryddc:540Materials ChemistryCeramics and CompositesBenzamide
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Protonation effects on the UV/Vis absorption spectra of imatinib: A theoretical and experimental study

2014

An experimental and theoretical investigation of protonation effects on the UV/Vis absorption spectra of imatinib showed systematic changes of absorption depending on the pH, and a new absorption band appeared below pH 2. These changes in the UV/Vis absorption spectra were interpreted using quantum chemical calculations. The geometry of various imatinib cations in the gas phase and in ethanol solution was optimized with the DFT/B3LYP method. The resultant geometries were compared to the experimentally determined crystal structures of imatinib salts. The semi-empirical ZINDO-CI method was employed to calculate the absorption lines and electronic transitions. Our study suggests that the forma…

Models MolecularAbsorption spectroscopyChemistryAntineoplastic AgentsProtonationCrystal structureCrystallography X-RayPhotochemistryPiperazinesAtomic and Molecular Physics and OpticsSpectral lineAnalytical ChemistryPyrimidinesUltraviolet visible spectroscopyAbsorption bandAtomic electron transitionhemic and lymphatic diseasesBenzamidesImatinib MesylateQuantum TheorySpectrophotometry UltravioletProtonsAbsorption (electromagnetic radiation)InstrumentationSpectroscopySpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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N-(INDAZOLYL)BENZAMIDO DERIVATIVES AS CDK1 INHIBITORS: DESIGN, SYNTHESIS, BIOLOGICAL ACTIVITY, AND MOLECULAR DOCKING STUDIES

2009

A series of N-1H-indazole-1-carboxamides has been synthesized and their effects on both CDK1/cyclin B and the K-562 (human chronic myelogenus leukemia) cell line were evaluated. Using a computational model, we have observed that all the most active compounds 9e, f, i-n exhibited the same binding mode of purvanalol A in the ATP-binding cleft. Although they were able to moderately inhibit the leukemic cell line K-562 and to show inhibitory activity against the Cdc2-Cyclin B kinase in the low micromolar range, they turned out to be non-cytotoxic against HuDe (IZSL) primary cell cultures from human derm. These preliminary results are quite encouraging in view of the low toxicity demonstrated by…

Models MolecularStereochemistryCyclin BPharmaceutical ScienceAntineoplastic AgentsCyclin BStructure-Activity RelationshipCDC2 Protein KinaseDrug DiscoveryHumansStructure–activity relationshipCell ProliferationCyclin-dependent kinase 1Binding SitesbiologyCell growthChemistryImidazolesN-(1H-indazolyl)benzamides 1H-indazole-3-carboxamides CDK1 Molecular dockingBiological activitySettore CHIM/08 - Chimica FarmaceuticaBiochemistryDocking (molecular)Cell cultureDrug DesignBenzamidesbiology.proteinDrug Screening Assays AntitumorK562 CellsCDC2 Protein KinaseProtein Binding
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CCDC 629530: Experimental Crystal Structure Determination

2007

Related Article: C.A.Jimenez, J.B.Belmar, F.S.Delgado, M.Julve, C.Ruiz-Perez|2007|CrystEngComm|9|746|doi:10.1039/b617605d

NN'-(22-dimethylpropane-13-diyl)bis(35-di-t-butyl-2-hydroxybenzamide)Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1443023: Experimental Crystal Structure Determination

2016

Related Article: Pierre-Emmanuel Doulain, Christine Goze, Ewen Bodio, Philippe Richard, Richard A. Decréau|2016|Chem.Commun.|52|4474|doi:10.1039/C5CC10526A

N-(2-(55-Difluoro-5H-6lambda55lambda5-dipyrrolo[12-c:2'1'-f][132]diazaborinin-10-yl)phenyl)-4-(dimethylamino)benzamide ethyl acetate solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 938974: Experimental Crystal Structure Determination

2014

Related Article: Lena Kaufmann, Nora L. Traulsen, Andreas Springer, Hendrik V. Schröder, Toni Mäkelä, Kari Rissanen, Christoph A. Schalley|2014|Org.Chem.Front.|1|521|doi:10.1039/C4QO00077C

N-(2-(hexanoyl(methyl)amino)ethyl)-N-methylbenzamide 11'-iodo-5'17'23'35'38'40'43'45'-octamethyl-7'15'25'33'39'-pentaazadispiro[cyclohexane-12'-heptacyclo[32.2.2.2^36^.2^1619^.2^2124^.1^913^.1^2731^]hexatetracontane-20'1''-cyclohexane]-1'(36')3'5'9'(44')10'12'16'18'21'23'27'(39')28'30'34'37'40'42'45'-octadecaene-8'14'26'32'-tetroneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 663805: Experimental Crystal Structure Determination

2007

Related Article: T.Lahtinen, K.Rissanen|2007|Acta Crystallogr.,Sect.E:Struct.Rep.Online|63|o4114|doi:10.1107/S1600536807044777

N-(3-(5-Aza-289-trioxa-1-silabicyclo(3.3.3)undecan-1-yl)propyl)pentafluorobenzamideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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