Search results for "Bilin"
showing 10 items of 377 documents
Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes
2016
Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular events. To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide association studies and independent replication in up to 5,825 individuals of European ancestry with diabetes and up to 46,061 without diabetes, followed by functional studies. Known associations of variants in CUBN, encoding cubilin, with the urinary albumin-to-creatinine ratio (UACR) were confirmed in the overall sample (P = 2.4 × 10−10). Gene-by-diabetes interactions were…
Selection of endogenous control genes for normalization of gene expression analysis after experimental brain trauma in mice.
2008
Quantitative measurements of gene expression require correction for tissue sample size, RNA quantity, and reverse transcription efficiency. This can be achieved by normalization with control genes. The study was designed to identify candidates not altered after brain trauma. Male C57Bl/6 mice were anesthetized with isoflurane, and a pneumatic brain trauma was induced by controlled cortical impact (CCI) on the right parietal cortex. Brains were removed at 15 min, and 3, 6, 12 and 24 h after CCI and from naive animals (n = 6 each). Absolute copies of six control genes (beta-2-microglobin [B2M], cyclophilin A, beta-actin, hypoxanthine ribosyltransferase [HPRT], porphobilinogen deaminase [PBGD]…
Understanding developmental language disorder-The Helsinki longitudinal SLI study (HelSLI): A study protocol
2018
Background Developmental language disorder (DLD, also called specific language impairment, SLI) is a common developmental disorder comprising the largest disability group in pre-school-aged children. Approximately 7% of the population is expected to have developmental language difficulties. However, the specific etiological factors leading to DLD are not yet known and even the typical linguistic features appear to vary by language. We present here a project that investigates DLD at multiple levels of analysis and aims to make the reliable prediction and early identification of the difficulties possible. Following the multiple deficit model of developmental disorders, we investigate the DLD …
Shotgun Proteomics of Isolated Urinary Extracellular Vesicles for Investigating Respiratory Impedance in Healthy Preschoolers
2021
Urine proteomic applications in children suggested their potential in discriminating between healthy subjects from those with respiratory diseases. The aim of the current study was to combine protein fractionation, by urinary extracellular vesicle isolation, and proteomics analysis in order to establish whether different patterns of respiratory impedance in healthy preschoolers can be characterized from a protein fingerprint. Twenty-one 3–5-yr-old healthy children, representative of 66 recruited subjects, were selected: 12 late preterm (LP) and 9 full-term (T) born. Children underwent measurement of respiratory impedance through Forced Oscillation Technique (FOT) and no significant differen…
Masked Translation Priming Effects With Highly Proficient Simultaneous Bilinguals
2010
One essential issue for models of bilingual memory organization is to what degree the representation from one of the languages is shared with the other language. In this study, we examine whether there is a symmetrical translation priming effect with highly proficient, simultaneous bilinguals. We conducted a masked priming lexical decision experiment with cognate and noncognate translation equivalents. Results showed a significant masked translation priming effect for both cognates and noncognates, with a greater priming effect for cognates. Furthermore, the magnitude of the translation priming was similar in the two directions. Thus, highly fluent bilinguals do develop symmetrical between…
Bilingualism at the core of the brain. Structural differences between bilinguals and monolinguals revealed by subcortical shape analysis.
2015
Naturally acquiring a language shapes the human brain through a long-lasting learning and practice process. This is supported by previous studies showing that managing more than one language from early childhood has an impact on brain structure and function. However, to what extent bilingual individuals present neuroanatomical peculiarities at the subcortical level with respect to monolinguals is yet not well understood, despite the key role of subcortical gray matter for a number of language functions, including monitoring of speech production and language control — two processes especially solicited by bilinguals. Here we addressed this issue by performing a subcortical surface-based anal…
Vocabulary teaching strategies and conceptual representations of words in L2 in children: evidence with novice learners.
2008
Abstract A controversial issue in bilingual research is whether in the early stages of L2 learning, access to the conceptual system involves mediation of L1 lexical representations [Kroll, J. F., & Stewart, E. (1994). Category interference in translation and picture naming: Evidence for asymmetric connections between bilingual memory representations. Journal of Memory and Language, 33, 149–174] or a direct route from the L2 word [Altarriba, J., & Mathis, K. M. (1997). Conceptual and lexical development in second language acquisition. Journal of Memory and Language, 36, 550–568; Finkbeiner, M., & Nicol, J. (2003). Semantic category effects in second language word learning. Applied Psycholing…
Effects of bilingualism on white matter atrophy in mild cognitive impairment: a diffusion tensor imaging study
2020
Background and purpose Previous investigations show that bilinguals exhibit the first symptoms of dementia 4-5 years later than monolinguals. Therefore, bilingualism has been proposed as a cognitive reserve mechanism. Recent studies have advanced towards an understanding of the brain mechanisms underlying bilingualism's protection against dementia, but none of them deals with white matter (WM) diffusion. Methods In this study, the topic was investigated by measuring WM integrity in a sample of 35 bilinguals and 53 passive bilinguals with mild cognitive impairment. Results No significant differences were found between the groups in cognitive level, education, age or sex. However, bilinguals …
A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures.
2020
Abstract Background Evidence from previous studies suggests that bilingualism contributes to cognitive reserve because bilinguals manifest the first symptoms of Alzheimer’s disease (AD) up to 5 years later than monolinguals. Other cross-sectional studies demonstrate that bilinguals show greater amounts of brain atrophy and hypometabolism than monolinguals, despite sharing the same diagnosis and suffering from the same symptoms. However, these studies may be biased by possible pre-existing between-group differences. Methods In this study, we used global parenchymal measures of atrophy and cognitive tests to investigate the protective effect of bilingualism against dementia cross-sectionally …
La poesía como lección de historia, Matei Vişniec, «En la mesa con Marx» («La masă cu Marx»)La poesía como lección de historia, Matei Vişniec, «En la…
2017
After a brief presentation describing the main traits of the literary Romanian exile, this article aims to reveal some aspects of Matei Vişniec’s poetical originality, a Romanian francophone writer who defines himself as a «lucky exiled man». The poem we’ve chosen, «At the table with Marx» («La masă cu Marx»), involves the main line of the book with the same title that was published in Romania in 2011. His explicitly political regard relates him to another text that circulated as an anti-communist manifesto during the previous years of the communist dictature fall: the well-known poem entitled «The sailing ship» («Corabia»). A parable of complicity and colective guiltiness, «At the table wi…