Search results for "Biochemistry"
showing 10 items of 20172 documents
�ber die �nderung der Kontraktionsamplitude des elektrisch gereizten Rattenpapillarmuskels nach einer Reizpause oder einer Periode hochfrequenter Rei…
1959
Isolated rat papillary muscles were stimulated electrically in a 50 ml. Tyrode bath at 37°C. Potentiation of contractile force following a period of rest and post-stimulation potentiation were studied.
Chronically Elevated Interleukin-6 Disturbs the Coagulation Cascade in Mice
2021
Abstract Introduction: Pro-inflammatory cytokines play an essential role as activators of the hemostatic system and in the regulation of physiological antithrombotic mechanisms. Interleukin-6 (IL-6) influences platelet production and platelet activation. It was associated with accelerated clotting and intravascular coagulation in tissue factor (TF)-driven murine thrombosis models. However, the precise role of myeloid cell-derived IL-6 on thrombosis formation and the hemostatic system is still unknown. Methods and Results: To better understand the role of IL-6 in thrombosis and the hemostatic system, we developed a new mouse strain with Cre-recombinase driven constitutive IL-6 expression spe…
Insights into the management of patients with MPS II: Key findings following 10years of the Hunter Outcome Survey (HOS)
2016
Measuring patient experiences in fabry disease: validation of the Fabry Outcome Survey (FOS) paediatric health and pain questionnaire
2011
Consensus recommendation on a diagnostic guideline for acid sphingomyelinase deficiency
2017
Severe High Molecular Weight Kininogen (HK) Deficiency: Clinical Characteristics, Deficiency-Causing KNG1 Variants in Reported and New Cases, and Est…
2021
Abstract Background: Severe high molecular weight kininogen (HK) deficiency is an autosomal recessive defect of the contact system caused by mutations in KNG1. Limited scientific interest in HK deficiency due to the rarity of the seemingly asymptomatic condition may increase, as HK, the precursor of bradykinin, is now discussed as a therapeutic target e.g. in hereditary angioedema. Aims: We provide a comprehensive analysis of the diagnostic, clinical, and genetic features of HK deficiency and estimate its frequency. Methods: We identified a new case of HK deficiency, systematically review the literature, conduct new genetic studies of reported cases, and comprehensively analyze the clinical…
Modulation of ROS levels as a strategy to improve healthy aging
2016
A Silybinphospholipid Complex Prevents Mitochondrial Oxidative Stress in Models of Chronic Liver Disease
2010
Oxidative stress and physical exercise: effects of training intervention on oxidative stress levels caused by endogenous and exogenous sources
2016
An unmet medical need:advances in endoscopic imaging of colorectal neoplasia
2011
Gastrointestinal cancer is a major public health problem worldwide. Detection of early neoplastic lesions in gastrointestinal tract is essential for cure, because prognosis and survival are related to the size and stage of malignant lesions. Endoscopic screening and treatment of polyps could prevent approximately 80% of colorectal cancer (CRC). However, white-light endoscopy is an imperfect technology since miss rates of up to 25% have been reported and polyps without malignant potential were treated without benefit but with additional costs and risks to the patient. There are several known "human" predictors of an inadequate colonoscopy. These include patient characteristics such as poor b…