Search results for "Biofilms"

Pyrrolomycins as novel agents against staphylococcal biofilms

2009

Bacterial biofilms: a challenge in the discovery of new anti-infective agents.

2010

The ability to form a biofilm, bacterial communities able to grow on surfaces and surrounded by an extracellular polymeric substance biofilm agents.Our research group focused on discovering of novel chemical agents of potential therapeutic utility in the treatment of staphylococcal biofilm-associatedinfections by screening novel compounds (synthetic or natural). In a recent study, the antistaphylococcalbiofilm activity of pyrrolomycins C,D, F1, F2a, F2b, F3 a family of halogenated pyrroles which are naturally produced byActinosporangium vitaminophylum and of the synthesized related compounds I, II, III were investigated and compared (Schillaci et al, 2010). We also focused on marine inverte…

Implicación y caracterización de Staphylococcus aureus en las poliposis nasales.

2016

La rinosinusitis crónica (RSC) es una enfermedad inflamatoria, de más de 12 semanas de duración, que afecta a la mucosa de las fosas nasales y de los senos paranasales. Se caracteriza por presentar, obstrucción o congestión nasal, y/o rinorrea; y además poder presentar uno de estos dos síntomas, dolor o sensación de presión facial, y/o pérdida total o parcial del sentido del olfato. La RSC se divide en dos grupos RSC con ausencia o RSC con presencia de poliposis nasal (PN). Además clínicamente la rinosinusitis crónica con presencia de poliposis nasal (RSCcPN) pueden subclasificarse en (a) RSCcPN eosinofílica, que es bilateral e idiopática, pudiendo presentarse de forma aislada, asociada a a…

Relationship between volume of submandibular salivary stones in vivo determined with cone-beam computer tomography and in vitro with micro-computer t…

2021

Background Successful removal of salivary stones depends on exact pretreatment information of the location, the size and shape of the stones. This study aimed to compare the volume of submandibular sialoliths determined by preoperative Cone-Beam Computer Tomography (CBCT) scans with the volume of the removed stones on micro-Computer Tomography (micro-CT) scans. Material and Methods In this study, using twenty-one submandibular sialoliths, the pretreatment volumes in-vivo measured on CBCT were compared to the volumes of removed stones determined by micro-CT scans. The volume measured on micro-CT scans served as the gold standard. Pre-operative CBCT’s and in-vitro micro-CT’s were converted in…

Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation

2020

Anti-virulence strategy is currently considered a promising approach to overcome the global threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilm formation is recognized as one of the most relevant. Considering the high and growing percentage of multi-drug resistant infections that are biofilm-mediated, new therapeutic agents capable of counteracting the formation of biofilms are urgently required. In this scenario, a new series of 18 thiazole derivatives was efficiently synthesized and evaluated for its ability to inhibit biofilm formation against the Gram-positive bacterial reference strains Staphylococcus aureus ATCC 25923 and S. aureus ATCC 6538 a…

Regulation of type 1 fimbriae synthesis and biofilm formation by the transcriptional regulator LrhA of Escherichia coli

2005

Type 1 fimbriae ofEscherichia colifacilitate attachment to the host mucosa and promote biofilm formation on abiotic surfaces. The transcriptional regulator LrhA, which is known as a repressor of flagellar, motility and chemotaxis genes, regulates biofilm formation and expression of type 1 fimbriae. Whole-genome expression profiling revealed that inactivation oflrhAresults in an increased expression of structural components of type 1 fimbriae.In vitro, LrhA bound to the promoter regions of the twofimrecombinases (FimB and FimE) that catalyse the inversion of thefimApromoter, and to the invertible element itself. TranslationallacZfusions with these genes and quantification offimEtranscript le…