Search results for "Bioinformatics"
showing 10 items of 1632 documents
Interaction between paracetamol and oral anticoagulants
2005
Hypothyreose, Hyperthyreose und Therapie mit Schilddrüsenhormonen: Einflüsse auf das Skelettsystem
2008
Kardiale Beteiligung bei Funktionsstörungen der Schilddrüse
2008
"Master-Slave" Biological Network Alignment
2010
Performing global alignment between protein-protein interaction (PPI) networks of different organisms is important to infer knowledge about conservation across species. Known methods that perform this task operate symmetrically, that is to say, they do not assign a distinct role to the input PPI networks. However, in most cases, the input networks are indeed distinguishable on the basis of how well the corresponding organism is biologically well-characterized. For well-characterized organisms the associated PPI network supposedly encode in a sound manner all the information about their proteins and associated interactions, which is far from being the case for not well characterized ones. He…
Statistically validated networks in bipartite complex systems.
2011
Many complex systems present an intrinsic bipartite nature and are often described and modeled in terms of networks [1-5]. Examples include movies and actors [1, 2, 4], authors and scientific papers [6-9], email accounts and emails [10], plants and animals that pollinate them [11, 12]. Bipartite networks are often very heterogeneous in the number of relationships that the elements of one set establish with the elements of the other set. When one constructs a projected network with nodes from only one set, the system heterogeneity makes it very difficult to identify preferential links between the elements. Here we introduce an unsupervised method to statistically validate each link of the pr…
Asymmetric Comparison and Querying of Biological Networks
2011
Comparing and querying the protein-protein interaction (PPI) networks of different organisms is important to infer knowledge about conservation across species. Known methods that perform these tasks operate symmetrically, i.e., they do not assign a distinct role to the input PPI networks. However, in most cases, the input networks are indeed distinguishable on the basis of how the corresponding organism is biologically well characterized. In this paper a new idea is developed, that is, to exploit differences in the characterization of organisms at hand in order to devise methods for comparing their PPI networks. We use the PPI network (called Master) of the best characterized organism as a …
Approximate Matching over Biological RDF Graphs
2012
In the last few years, the amount of biological interaction data discovered and stored in public databases (e.g., KEGG [2]) considerably increased. To this aim, RDF is a powerful representation for interactions (or pathways), since they can be modeled as directed graphs, often referred to as biological networks, where nodes represent cellular components and the (labeled or unlabeled) edges correspond to interactions among components. Often for a given organism some components are known to be linked by well studied interactions. Such groups of components are called modules and they can be represented by sub-graphs in the corresponding biological network model. At today, one of the most impor…
Gradation of Fuzzy Preconcept Lattices
2021
Noticing certain limitations of concept lattices in the fuzzy context, especially in view of their practical applications, in this paper, we propose a more general approach based on what we call graded fuzzy preconcept lattices. We believe that this approach is more adequate for dealing with fuzzy information then the one based on fuzzy concept lattices. We consider two possible gradation methods of fuzzy preconcept lattice—an inner one, called D-gradation and an outer one, called M-gradation, study their properties, and illustrate by a series of examples, in particular, of practical nature.
Algorithmics for the Life Sciences
2013
The life sciences, in particular molecular biology and medicine, have wit- nessed fundamental progress since the discovery of the “the Double Helix”. A rele- vant part of such an incredible advancement in knowledge has been possible thanks to synergies with the mathematical sciences, on the one hand, and computer science, on the other. Here we review some of the most relevant aspects of this cooperation focusing on contributions given by the design, analysis and engineering of fast al- gorithms for the life sciences.
An ontological-based knowledge organization for bioinformatics workflow management system
2012
Motivation and Objectives In the field of Computer Science, ontologies represent formal structures to define and organize knowledge of a specific application domain (Chandrasekaran et al., 1999). An ontology is composed of entities, called classes, and relationships among them. Classes are characterized by features, called attributes, and they can be arranged into a hierarchical organization. Ontologies are a fundamental instrument in Artificial Intelligence for the development of Knowledge-Based Systems (KBS). With its formal and well defined structure, in fact, an ontology provides a machine-understandable language that allows automatic reasoning for problems resolution. Typical KBS are E…