Search results for "Bioinformatics"
showing 10 items of 1632 documents
Vairāku sekvenču izlīdzināšanas metožu salīdzinājums
2021
Šajā maģistra darbā paredzēts izpētīt, aprakstīt un salīdzināt dažādas praksē pieejamas vairāku sekvenču izlīdzināšanas metodes. Darbā tiek aprakstīti vairāku sekvenču izlīdzināšanas metožu galvenie pielietojumi bioinformātikā, biežāk sastopamie algoritmi, kuri tiek izmantoti darbā tālāk apskatītajās programmā. Īsi aprakstītas atvērtā koda programmas, kuras industrijā tiek izmantotas visbiežāk. Maģistra darba ietvaros veikts praktisks pētījums par šo metožu priekšrocībām un trūkumiem. Salīdzinājums veikts gan uz reāliem datu masīviem, gan simulētiem, lai spētu pēc iespējas daudzpusīgāk salīdzināt pieejamo programmatūru. Veikta iegūto rezultātu grafiska atspoguļošana un analīze par novērojam…
Peptide classification using optimal and information theoretic syntactic modeling
2010
Accepted version of an article published in the journal: Pattern Recognition. Published version available on Sciverse: http://dx.doi.org/10.1016/j.patcog.2010.05.022 We consider the problem of classifying peptides using the information residing in their syntactic representations. This problem, which has been studied for more than a decade, has typically been investigated using distance-based metrics that involve the edit operations required in the peptide comparisons. In this paper, we shall demonstrate that the Optimal and Information Theoretic (OIT) model of Oommen and Kashyap [22] applicable for syntactic pattern recognition can be used to tackle peptide classification problem. We advoca…
Activación plaquetaria e hipercolesterolemia en la patogenia de la trombosis venosa profunda
2006
Currently it is accepted that deep vein thrombosis is a multifactorial event in which the presence of activated platelets and also plasmatic lipids seems to play a pivotal role that it is not well established in the scientific bibliography. Due to the non consensus state about these topics between the different groups working in these aspects, the topic involving deep vein thrombosis-platelets-lipids, and also their interactions, still is an interesting area of investigation, in which it is necessary to carry out studies with the aim of establishing risk factors, initial diagnostic methods and clinical assays to probe the efficacy of new therapies.
Global prevalence and genotype distribution of hepatitis C virus infection in 2015:a modelling study
2017
WOS: 000426979400014
In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach
2011
In the present study, 21 validated QSAR models that discriminate compounds with high Caco-2 permeability (Papp ≥8×10(-6) cm/s) from those with moderate-poor permeability (Papp <8×10(-6) cm/s) were developed on a novel large dataset of 674 compounds. 20 DRAGON descriptor families were used. The global accuracies of obtained models were ranking between 78-82 %. A general model combining all types of molecular descriptors was developed and it classified correctly 81.56 % and 83.94 % for training and test sets, respectively. An external set of 10 compounds was predicted and 80 % was correctly assessed by in vitro Caco-2 assays. The potential use of the final model was evaluated by a virtual s…
Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction
2013
The Visceral Adiposity Index (VAI) has recently proven to be an indicator of adipose distribution and function that indirectly expresses cardiometabolic risk. In addition, VAI has been proposed as a useful tool for early detection of a condition of cardiometabolic risk before it develops into an overt metabolic syndrome. The application of the VAI in particular populations of patients (women with polycystic ovary syndrome, patients with acromegaly, patients with NAFLD/NASH, patients with HCV hepatitis, patients with type 2 diabetes, and general population) has produced interesting results, which have led to the hypothesis that the VAI could be considered a marker of adipose tissue dysfuncti…
Distance measures for biological sequences: Some recent approaches
2008
AbstractSequence comparison has become a very essential tool in modern molecular biology. In fact, in biomolecular sequences high similarity usually implies significant functional or structural similarity. Traditional approaches use techniques that are based on sequence alignment able to measure character level differences. However, the recent developments of whole genome sequencing technology give rise to need of similarity measures able to capture the rearrangements involving large segments contained in the sequences. This paper is devoted to illustrate different methods recently introduced for the alignment-free comparison of biological sequences. Goal of the paper is both to highlight t…
Mammalian cell metabolomics: Experimental design and sample preparation
2013
Metabolomics represents the global assessment of metabolites in a biological sample and reports the closest information to the phenotype of the biological system under study. Mammalian cell metabolomics has emerged as a promising tool with potential applications in many biotechnology and research areas. Metabolomics workflow includes experimental design, sampling, sample processing, metabolite analysis, and data processing. Given their influence on metabolite content and biological interpretation of data, a good experimental design and the appropriate choice of a sample processing method are prerequisites for success in any metabolomic study. The use of mammalian cells in the metabolomics f…
Real-time 3D TUG test movement analysis for balance assessment using Microsoft Kinect
2014
International audience
Analyse cinématique des caractéristiques de planifications motrices chez les personnes âgées fragiles
2015
International audience