Search results for "Biomaterial"

Data concerning the protein absorption and retention properties of xyloglucan-based hydrogel film

2018

In wound dressing applications, exudate absorption and retention are important properties. The data presented here assess the ability of the crosslinked xyloglucan-poly(vinyl alcohol) hydrogel films (XG-PVA), described in "Xyloglucan-based hydrogel films for wound dressing: Structure-property relationships" (Ajovalasit et al., 2018) [1] and "Biocompatibility, hemocompatibility and antimicrobial properties of xyloglucan-based hydrogel film for wound healing application" (Picone et al., 2019), to absorb and retain proteins. These properties were investigated by Comassie blue staining and electrophoresis of Fetal Serum Proteins. (C) 2018 The Authors. Published by Elsevier Inc. This is an open …

A Comprehensive Utility Function for Resource Allocation in Mobile Edge Computing

2020

In mobile edge computing (MEC), one of the important challenges is how much resources of which mobile edge server (MES) should be allocated to which user equipment (UE). The existing resource allocation schemes only consider CPU as the requested resource and assume utility for MESs as either a random variable or dependent on the requested CPU only. This paper presents a novel comprehensive utility function for resource allocation in MEC. The utility function considers the heterogeneous nature of applications that a UE offloads to MES. The proposed utility function considers all important parameters, including CPU, RAM, hard disk space, required time, and distance, to calculate a more realis…

Template-Based Fabrication of Nanometer-Scaled Actuators from Liquid-Crystalline Elastomers

2010

Configurable low-cost plotter device for fabrication of multi-color sub-cellular scale microarrays.

2014

We report on the construction and operation of a low-cost plotter for fabrication of microarrays for multiplexed single-cell analyses. The printing head consists of polymeric pyramidal pens mounted on a rotation stage installed on an aluminium frame. This construction enables printing of microarrays onto glass substrates mounted on a tilt stage, controlled by a Lab-View operated user interface. The plotter can be assembled by typical academic workshops from components of less than 15 000 Euro. The functionality of the instrument is demonstrated by printing DNA microarrays on the area of 0.5 squared centimeters using up to three different oligonucleotides. Typical feature sizes are 5 μm diam…

General Principles for the Detection of Modified Nucleotides in RNA by Specific Reagents.

2021

Epitranscriptomics heavily rely on chemical reagents for the detection, quantification, and localization of modified nucleotides in transcriptomes. Recent years have seen a surge in mapping methods that use innovative and rediscovered organic chemistry in high throughput approaches. While this has brought about a leap of progress in this young field, it has also become clear that the different chemistries feature variegated specificity and selectivity. The associated error rates, e.g., in terms of false positives and false negatives, are in large part inherent to the chemistry employed. This means that even assuming technically perfect execution, the interpretation of mapping results issuin…

Modified Silk with Cell-Adhesive and Non-Thrombogenic Properties as a Tissue Engineering Substrate

2016

IntroductionReplacement of damaged tissue is nowadays an aim of tissue engineering. This technique involves the use of porous or fibrous structures – the so-called scaffolds – that support the colonization with the desired cell type and which are degraded after fulfilling their temporary supporting function. Basic requirements for the prevailing materials used in this field are nontoxicity, low immunogenicity and cell-adhesiveness. Furthermore blood-contacting devices should exhibit low thrombogenicity.The biopolymer silk, mainly consisiting of the protein silk fibroin, matches some of these criteria but bare silk does not facilitate cellular adhesion and growth and unfortunately the materi…

Effect of aggregation of a dispersed rigid filler on the elastic characteristics of a polymer composite

1986

We proposed a method for describing the effective elastic characteristics of a polymer composite with a rigid aggregating filler. An important feature of such a medium is the variable coupling of the inclusion phase in relation to its volume content. A change in the degree of coupling of the filler is accounted for by introducing an additional parameter. We examined a method of determining the coupling parameter from the results of statistical modeling of the geometry of the medium. Using the example of a calcite-HDPE composite, we showed that aggregation has a significant effect on the dependence of the elastic modulus on the volume content of filler; satisfactory agreement was obtained be…

The importance of correct implants positioning and masticatory load direction on a fixed prosthesis

2018

Background Through the biomechanical study of dental implants, it is possible to understand the dissipation effects of masticatory loads in different situations and prevent the longevity of osseointegration. Aims: To evaluate the microstrains generated around external hexagon implants, using axial and non-axial loads in a fixed four-element prosthesis with straight implants and implants inclined at 17°. Material and Methods Three implants were modeled using CAD software following the manufacturer's measurements. Then, implants were duplicated and divided into two groups: one with straight implants and respective abutments, and the other with angled implants at 17° and respective abutments. …

Probing ensemble polymorphism and single aggregate structural heterogeneity in insulin amyloid self-assembly.

2020

Ensembles of protein aggregates are characterized by a nano- and micro-scale heterogeneity of the species. This diversity translates into a variety of effects that protein aggregates may have in biological systems, both in connection to neurodegenerative diseases and immunogenic risk of protein drug products. Moreover, this naturally occurring variety offers unique opportunities in the field of protein-based biomaterials. In the above-mentioned fields, the isolation and structural analysis of the different amyloid types within the same ensemble remain a priority, still representing a significant experimental challenge. Here we address such complexity in the case of insulin for its relevance…

Multinucleated giant cells in the implant bed of bone substitutes are foreign body giant cells-New insights into the material-mediated healing process

2017

In addition to macrophages, multinucleated giant cells (MNGCs) are involved in the tissue reaction to a variety of biomaterials. Especially in the case of bone substitute materials it has been assumed that the MNGCs are osteoclasts, based on the chemical and physical similarity of many materials to the calcified matrix and the bony environment in which they are used. However, many studies indicate that these cells belong to the cell line of the foreign body giant cells (FBGCs), which are of "inflammatory origin", although they have been shown to possess both a pro- and also anti-inflammatory phenotype. Moreover, no information is available about their role in the tissue reaction to bone sub…