Search results for "Biomedical Research"

Proteomic Strategies and their Application in Cancer Research

2006

The understanding of carcinogenesis and tumor progression on a molecular basis needs a detailed study of proteins as effector molecules and as critical components of the multiple interconnected signaling pathways that drive the neoplastic phenotype. Thus, the proteomic approach represents a powerful tool for the challenge of the post-genomic era. The term “cancer proteome” refers to the collection of proteins expressed by a given cancer cell and should be considered as a highly dynamic entity within the cell, which affects a variety of cellular activities. The emerging proteomic analysis platforms including 2D-PAGE, mass spectrometry technologies, and protein microarrays represent powerful…

Biomedical applications of ion mobility-enhanced data-independent acquisition-based label-free quantitative proteomics.

2014

Mass spectrometry-based proteomics greatly benefited from recent improvements in instrument performance and the development of bioinformatics solutions facilitating the high-throughput quantification of proteins in complex biological samples. In addition to quantification approaches using stable isotope labeling, label-free quantification has emerged as the method of choice for many laboratories. Over the last years, data-independent acquisition approaches have gained increasing popularity. The integration of ion mobility separation into commercial instruments enabled researchers to achieve deep proteome coverage from limiting sample amounts. Additionally, ion mobility provides a new dimens…

Scientific Publications and Research Groups on Alcohol Consumption and Related Problems Worldwide: Authorship Analysis of Papers Indexed in PubMed an…

2011

BACKGROUND: The research of alcohol consumption-related problems is a multidisciplinary field. The aim of this study is to analyze the worldwide scientific production in the area of alcohol-drinking and alcohol-related problems from 2005 to 2009. METHODS: A MEDLINE and Scopus search on alcohol (alcohol-drinking and alcohol-related problems) published from 2005 to 2009 was carried out. Using bibliometric indicators, the distribution of the publications was determined within the journals that publish said articles, specialty of the journal (broad subject terms), article type, language of the publication, and country where the journal is published. Also, authorship characteristics were assesse…

Mapping the landscape of urology: A new media-based cross-sectional analysis of public versus academic interest.

2018

Objectives To quantify public and academic interest in the urological field using a novel new media-based methodology. Methods We systematically measured public and academic interest in 56 urological keywords and combined in nine subspecialties. Public interest was quantified as video views on YouTube. Academic interest was quantified as article citations using Microsoft Academic Search. The public-to-academic interest ratio was calculated for a comparison of subspecialties as well as for diseases and treatments. Results For the selected 56 urological keywords, we found 226 617 591 video views on YouTube and 2 146 287 citations in the academic literature. The public-to-academic interest rat…

Science integrity has been never more important: It's all about trust.

2021

Cardiovascular Scientific Production in Spain and in the European and Global Context (2003-2007)

2009

Introduction and objectives The publication of research articles has increased considerably in recent years in all biomedical fields. The present study examines the position of Spanish quality research in cardiology in the European and world context, and its evolution during the 5-year period 2003-2007. Methods Using the Science Citation Index Expanded of Thomson Reuters as data source, we compared Spanish cardiovascular scientific production with that of the rest of countries in the European Union and of the most important countries worldwide, along with relative productivity as per number of inhabitants and Gross Domestic Product, and the number of citations in the journals of the Cardiac…

Integrity measures take its toll: Introducing a complete supplement issue with retractions only.

2021

Scientific production in clinical medicine and international collaboration networks in South American countries

2012

Background: International collaboration is increasingly used in biomedical research. Aim: To describe the characteristics of scientific production in Latin America and the main international collaboration networks for the period 2000 to 2009. Material and Methods: Search for papers generated in Latin American countries in the Clinical Medicine database of ISI Web of Knowledge v.4.10 - Current Contents Connect. The country of origin of the corresponding author was considered the producing country of the paper. International collaboration was analyzed calculating the number of countries that contributed to the generation of a particular paper. Collaboration networks were graphed to determine …

Spanish Production of Research Articles on Diagnostic Imaging in Cardiology and Radiology (1994-1998)

2004

Introduction and objectives. The aim of this study was to evaluate the production of research papers by Spanish authors on diagnostic imaging published in the official journals of two Spanish scientific societies (REVISTA ESPANOLA DE CARDIOLOGIA and Radiologia) between 1994 and 1998, and to compare publication rates with those of research papers published in foreign cardiological and radiological journals included in Journal Citation Reports. Material and method. Specific search profiles were devised to retrieve items from the Indice Medico Espanol (IME) and MEDLINE databases. The impact factor for non-Spanish journals devoted to different specialties was normalized for the number of papers…

The European Sleep Apnoea Database (ESADA) ERS Clinical Research Collaboration: past, present and future

2018

There are some critical issues that determine the sustainability of the ESADA project in the long term. We need to develop strategies to maintain high data quality and enable new research activities related to the database. Funding may be provided by public and academic institutions or by collaborations with industry. We plan to submit EU research or public health projects, and cooperation with other cohorts will help to reach the critical mass necessary to cover the entire European area. Again, the CRC is a very good opportunity to pursue this goal, not only for the visibility provided by the endorsement of a leading society like the ERS, but also for the practical support in submission of…