Search results for "Biomedical"
showing 10 items of 2328 documents
Biomechanical analysis of the humeral tray positioning in reverse shoulder arthroplasty design
2017
Despite the widespread use of reverse total shoulder arthroplasty, the fundamental effects of implant configuration on certain biomechanical outcomes have not been completely elucidated especially for the most innovative prostheses. Aim of this work is to investigate the behaviour of a new reverse shoulder prosthesis, characterized by a humeral tray with a variable offset, designed to increase the range of motion and to reduce the impingement. The purposes of this study were to evaluate the effect of reverse shoulder implant design parameters on the deltoid muscle forces, required to produce abduction, and on the shoulder range of motion, in order to provide a more systematic understanding …
Three dimensional reconstruction of intracoronary ultrasound images: roadmapping with simultaneously digitised coronary angiograms
2002
Three dimensional reconstruction of intracoronary ultrasound images offers a better appreciation of the axial relationship of vessel features and permits volumetric assessment, both of which depend critically on the spatial accuracy of the technique. This in turn is dependent on precise longitudinal orientation of the transducer in the vessel. The authors have developed a system which utilises simultaneously digitised fluoroscopic tracking of the radio-opaque transducer to orient the corresponding 2D ICUS images. This system may offer improved spatial accuracy of the three dimensional reconstruction and a means of precise identification of the 2D ICUS image which corresponds with a selected…
An open access database for the evaluation of heart sound algorithms
2016
In the past few decades, analysis of heart sound signals (i.e. the phonocardiogram or PCG), especially for automated heart sound segmentation and classification, has been widely studied and has been reported to have the potential value to detect pathology accurately in clinical applications. However, comparative analyses of algorithms in the literature have been hindered by the lack of high-quality, rigorously validated, and standardized open databases of heart sound recordings. This paper describes a public heart sound database, assembled for an international competition, the PhysioNet/Computing in Cardiology (CinC) Challenge 2016. The archive comprises nine different heart sound databases…
Curcumin entrapped into lipid nanosystems inhibits neuroblastoma cancer cell growth and activates Hsp70 protein
2010
Curcumin is a natural anti-cancer compound utilized on a wide variety of human cancer cell lines and animal carcinogenesis models. However, its clinical application has been limited for its minimal systemic bioavailability. Nanoparticle-based drug delivery approaches have the potential for rendering hydrophobic molecules such as curcumin dispersible in aqueous media, thus overtaking the limits of its poor solubility. In this paper, we reported the preparation and chemical-physical characterization of Nanostructured Lipid Carriers (NLC) containing curcumin, based on Imwitor, Compritol or Precirol as lipid matrix. By in vitro experiments, we have demonstrated that these nano-systems are able …
Use and acceptance of new technology by older people. Findings of the international MOBILATE survey: ‘Enhancing mobility in later life’
2005
Technology has become part of today’s life. It constitutes a fundamental aspect of the environment also for older people who are not familiar with most of the new technologies. Is their use of technology based on certain abilities and is this related with such factors as income, lack of alternatives, past performance, or availability of equipment? Methods The MOBILATE 2000 database of a survey conducted in 5 European countries was aimed at the enhancement of out-of-home mobility of older people. The project offers data describing the use and acceptance of new technologies. Insight can be gained into the characteristics of users and non-users of more or less common technologies like ATM, tic…
Special Issue on “Frontier Biomechanical Challenges in Cardiovascular Physiopathology”
2017
This special issue collects a number of original contributions, which were presented and discussed during the thematic Symposium organized by the Italian Chapter of the European Society of Biomechanics (ESB) in collaboration with the Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT – IRCCS), the Fondazione RiMED and the University of Palermo. The Symposium focused on recent advances in cardiovascular biomechanics, and the promise they hold for clinical therapeutic strategies and future research.
Finite element analysis of two total knee joint prostheses
2012
Aim of this work is to compare two different total knee prostheses that differ mainly in the shape of the polyethylene (PE) component inserted between the femoral and tibial plates. The best solution between them has been originally reshaped in order to reduce stress peaks. The study procedure has been divided into the following steps. First step is the digitalisation of the shape of the prostheses by means of a 3D laser scanner. The morphology of two prototypes of the prostheses has been acquired by elaborating multiple Moire fringe patterns projected on their surfaces. Second step consisted on the manipulation of these data in a CAD module, that is the interpolation of raw data into NURBS…
Effect of Motion Artifact on Digital Camera Based Heart Rate Measurement
2017
International audience; Depression is one of the most prevalent mental disorders, burdening many people world-wide. A system with the potential of serving as a decision support system is proposed, based on novel features extracted from facial expression geometry and speech, by interpreting non-verbal manifestations of depression. The proposed system has been tested both in gender independent and gender based modes, and with different fusion methods. The algorithms were evaluated for several combinations of parameters and classification schemes, on the dataset provided by the Audio/Visual Emotion Challenge of 2013 and 2014. The proposed framework achieved a precision of 94.8% for detecting p…
Three-dimensional cardiac computational modelling: methods, features and applications
2015
[EN] The combination of computational models and biophysical simulations can help to interpret an array of experimental data and contribute to the understanding, diagnosis and treatment of complex diseases such as cardiac arrhythmias. For this reason, three-dimensional (3D) cardiac computational modelling is currently a rising field of research. The advance of medical imaging technology over the last decades has allowed the evolution from generic to patient-specific 3D cardiac models that faithfully represent the anatomy and different cardiac features of a given alive subject. Here we analyse sixty representative 3D cardiac computational models developed and published during the last fifty …
Validation of portable 2D force binding systems for cross-country skiing
2013
The aim of the present study was to design, construct and scientifically validate a two-dimensional force measurement binding system for cross-country skiing. The system consists of two force measurement bindings. One binding was designed for analysing classic skiing (vertical and anterior–posterior [along the ski] force components) and the other one for skate (freestyle) skiing (vertical and medio-lateral [transverse to the ski] force components). Validation was accomplished using a three-step process: (1) accuracy tests for the sensors in two temperatures, (2) sport-specific imitation jump test on standard force plates in a laboratory and (3) comparing the system against force measurement…