Search results for "Biophysics"

Solubilization of an oligomycin-sensitive ATPase complex fromRhodospirillum rubrumchromatophores and its inhibition by various antibiotics

1978

Synthetic/ECM-inspired hybrid platform for hollow microcarriers with ROS-triggered nanoporation hallmarks

2017

Reactive oxygen species (ROS) are key pathological signals expressed in inflammatory diseases such as cancer, ischemic conditions and atherosclerosis. An ideal drug delivery system should not only be responsive to these signals but also should not elicit an unfavourable host response. This study presents an innovative platform for drug delivery where a natural/synthetic composite system composed of collagen type I and a synthesized polythioether, ensures a dual stimuli-responsive behaviour. Collagen type I is an extracellular matrix constituent protein, responsive to matrix metalloproteinases (MMP) cleavage per se. Polythioethers are stable synthetic polymers characterized by the presence o…

Protein dynamical transition vs. liquid-liquid phase transition in protein hydration water

2013

In this work, we compare experimental data on myoglobin hydrated powders from elastic neutron scattering, broadband dielectric spectroscopy, and differential scanning calorimetry. Our aim is to obtain new insights on the connection between the protein dynamical transition, a fundamental phenomenon observed in proteins whose physical origin is highly debated, and the liquid-liquid phase transition (LLPT) possibly occurring in protein hydration water and related to the existence of a low temperature critical point in supercooled water. Our results provide a consistent thermodynamic/dynamic description which gives experimental support to the LLPT hypothesis and further reveals how fundamental …

Correlations of isokinetic and psychophysical back lift and static back extensor endurance tests in men

1994

Isokinetic lift, psychophysical lift, and static back endurance tests are among the most widely used measurements of muscle function for determining risk for, and recovery from, back problems. After determining test repeatability we examined the degree of association between these test measures in 100 men selected to represent a variety of occupations and lifestyles. Isokinetic lifting had low correlations with test results for psychophysical lifting (r = 0.28) and static back endurance (r = 0.24). Static back endurance and psychophysical lift test results were not at all correlated (r = 0.03). RELEVANCE--:Muscle function measurements for back problems are sometimes arbitrarily selected due…

The bromine nuclear quadrupole moment revisited

2013

For the bromine atom and the hydrogen bromide molecule, we report results for the electric-field gradient at the bromine nucleus based on quantum-chemical calculations. Highly accurate values are obtained by using coupled-cluster methods for the treatment of electron correlation, by minimising remaining basis-set effects through the use of large atomic-orbital sets, and by taking into account relativistic effects. For hydrogen bromide, zero-point vibrational corrections are considered as well. The obtained results for the bromine electric-field gradients are used to derive values for the Br-79 quadrupole moment: 308.1 and 309.3 mb based on data for the bromine atom and hydrogen bromide, res…

23. Resting state functional magnetic resonance imaging analysis of the brain of pathological gamblers

2018

Purpose Gambling disorder has been recently reclassified under the category “substance-related and addictive disorders”. Recent studies performed through functional MRI (fMRI) have shown that the perseverance of some behaviors can alter brain activation [1] , [2] . In this work we aim at investigating functional connectivity changes in pathological gamblers (PGs) in comparison to healthy controls (HCs) by means of resting state functional Magnetic Resonance Imaging (rs-fMRI). Methods and materials Thirteen HCs and fourteen PGs were recruited (all right handed males; drugs free; mean age 36 ± 10 yrs). All acquisitions were performed through a 1,5 T MRI scanner using a 8-channels phased-array…

Spreading Depression Induces Permanent Cell Swelling Under Penumbra Conditions

2000

Background. Spreading depression (SD) is known to go along with temporary breakdown of ion gradients and cell swelling which spontaneously normalizes. Here, the effects of SD at reduced flow conditions as encountered in the ischemic penumbra are examined.

Comparative evaluation of data preprocessing software tools to increase efficiency and accuracy in diffusion kurtosis imaging

2016

26P Cellulose beads prepared in deep eutectic solvent function as carrier and cytoprotective encapsulation matrix for CAR-T cells in T-cell therapy a…

2020

Cybertherapy meets Facebook, Blogger and Second Life: an Italian experience

2009

Our project is based on the study of Cybertherapy in the international sphere (USA, Northern Europe) and on the application of this discipline to the Italian psychiatric and psychological reality. CyberTherapy can be used as an "aim", referring to it as real and proper therapy, which lives on personalized paths created by a qualified staff, conceived as ludic, for recreational, psycoterapic, and educational purpose. Moreover, Cybertherapy can be used as a "mean" (and in this way we want to propose it) with the aim of making the user, who feels a psychiatric or a psychological uneasiness, to become closer to qualified staff; a considerable advantage of this discipline is to reduce to a minim…