Search results for "Bios"

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD

2007

B cell homeostasis is regulated by multiple signaling processes, including nuclear factor-kappaB (NF-kappaB), BAFF-, and B cell receptor signaling. Conditional disruption of genes involved in these pathways has shed light on the mechanisms governing signaling from the cell surface to the nucleus. We describe a novel mouse strain that expresses solely and excessively a naturally occurring splice variant of CYLD (CYLD(ex7/8) mice), which is a deubiquitinating enzyme that is integral to NF-kappaB signaling. This shorter CYLD protein lacks the TRAF2 and NEMO binding sites present in full-length CYLD. A dramatic expansion of mature B lymphocyte populations in all peripheral lymphoid organs occur…

Triassic lingulide brachiopods from the Iberian Range (Spain)

1999

Abstract During the Middle Triassic marine transgression in Spain, several lingulide populations were fossilized in the Iberian Range (western part of Sephardic Province) and the recorded specimens have been described previously under several specific names. The paleontological aspects of the Jalance (Valencia province) section have been studied for the first time. Its exceptionally large population was fossilized in situ as flat-lying valves and can be interpreted as an autochthonous association related to a very shallow marine environment. The lingulide specimens belong to the genus Lingularia Biernat & Emig , 1993 , but the species name remains under debate, probably Lingularia smirnovae…

The armoured mite fauna (Acari: Oribatida) from a long-term study in the Scots pine forest of the Northern Vidzeme Biosphere Reserve, Latvia

2014

In 1992-2012, a considerable amount of soil micro-arthropods has been collected annually as a part of a project of the National Long-Term Ecological Research Network of Latvia at the Mazsalaca Scots Pine forest sites of the North Vidzeme Biosphere Reserve. Until now, the data on oribatid species have not been published. This paper presents a list of oribatid species collected during 21 years of ongoing research in three pine stands of different age. The faunistic records refer to 84 species (including 17 species new to the fauna of Latvia), 1 subspecies, 1 form, 5 morphospecies and 18 unidentified taxa. The most dominant and most frequent oribatid species are Oppiella (Oppiella) nova, Tecto…

Horizon scanning the European bio‐based economy: a novel approach to the identification of barriers and key policy interventions from stakeholders in…

2016

There is international recognition that developing a climate-smart bioeconomy is essential to the continuation of economic development, reduction of greenhouse gas emissions, and adaptation to climatic change; Bio-based products have an important role in making this transition happen. Supporting policy interventions have been put forward at European and national levels to support innovation and development of bio-based products and services. This study asks whether suggested policy interventions reflect the needs of stakeholders and examines how these needs vary between European regions. This consultation was performed through an online survey of 447 experts actively involved in bio-based r…

Effects of essential oils and selected compounds from Lamiaceae family as adjutants on the treatment of subjects with periodontitis and cardiovascula…

2021

Essential oils from different plant species were found to contain different compounds exhibiting anti-inflammatory effects with the potential to be a valid alternative to conventional chemotherapy that is limited in long-term use due to its serious side effects. Generally, the first mechanism by which an organism counteracts injurious stimuli is inflammation, which is considered a part of the innate immune system. Periodontitis is an infectious and inflammatory disease caused by a dysbiosis in the subgingival microbiome that triggers an exacerbated immune response of the host. The immune–inflammatory component leads to the destruction of gingival and alveolar bone tissue. The main anti-infl…

A homolog of the putative tumor suppressor QM in the sponge Suberites domuncula: downregulation during the transition from immortal to mortal (apopto…

1999

Abstract The activation of components of the transcription factors such as AP-1 or c-jun is essential for a physiological response of metazoan cells during aging. The activity of such proto-oncoproteins is under enzymatic control. The function of c-jun is additionally modulated by the QM protein. Here, we studied the expression of the gene, encoding the QM-like protein in the sponge Suberites domuncula . These animals contain high levels of telomerase in their somatic cells. To understand the switch from telomerase-positive immortal cells to telomerase-negative mortal cells which undergo apoptosis, the expression of the QM-like gene was measured in this system. The cDNA, termed QMSD , encod…

Rapid and eco-friendly synthesis of graphene oxide-silica nanohybrids

2014

Random Tanglegram Partitions (Random TaPas): An Alexandrian Approach to the Cophylogenetic Gordian Knot

2018

Abstract Symbiosis is a key driver of evolutionary novelty and ecological diversity, but our understanding of how macroevolutionary processes originate extant symbiotic associations is still very incomplete. Cophylogenetic tools are used to assess the congruence between the phylogenies of two groups of organisms related by extant associations. If phylogenetic congruence is higher than expected by chance, we conclude that there is cophylogenetic signal in the system under study. However, how to quantify cophylogenetic signal is still an open issue. We present a novel approach, Random Tanglegram Partitions (Random TaPas) that applies a given global-fit method to random partial tanglegrams of …

The new world of biosimilars: what diabetologists need to know about biosimilar insulins

2010

Biosimilar pharmaceuticals are emerging as patent protection on the original biopharmaceutical products expires. However, biopharmaceuticals are particularly complex molecules, and biosimilar insulins present special challenges. In part this reflects their structure and chemical modification after synthesis to attain a biologically active form. Their therapeutic window is narrow and the accuracy of their dosing is highly dependent on the formulation and quality of the administration device. For these reasons, the European Medicines Agency has issued stringent guidelines that must be fulfilled in order to receive approval as a biosimilar soluble insulin. Prescribers should therefore consider…

Eomyops noeliae sp. nov., a new Eomyidae (Mammalia, Rodentia) from the Aragonian of Spain

2009

Abstract A new species of Eomyops, Eomyops noeliae, is described. from the locality MT-20A (Morteral section, Magro basin, eastern Spain). It is intermediate in size between the large eomiid, E. hebeiseni, and the small species of the group E. catalaunicus, E. bodvanus and E. oppligeri. The age range is Lower Aragonian. MT-20A is located between deposits that contain Megacricetodon primitivus and M. collongensis. Morphologically, E. noeliae sp. nov. is clearly different from the rest of species of the genus, due to an important reduction of the lingual anteroloph of M1,2,3 and the labial anterolophid of M3. The lower incisor shows two parallel ridges along the enamel like the type species o…