Search results for "Bk"
showing 10 items of 151 documents
11,12-EET Stimulates the Association of BK Channel α and β1 Subunits in Mitochondria to Induce Pulmonary Vasoconstriction
2012
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca(2+)-activated potassium (BK) channels. However, in the lung 11,12-EET contributes to hypoxia-induced pulmonary vasoconstriction. Since pulmonary artery smooth muscle cells also express BK channels, we assessed the consequences of BKβ(1) subunit deletion on pulmonary responsiveness to 11,12-EET as well as to acute hypoxia. In buffer-perfused mouse lungs, hypoxia increased pulmonary artery pressure and this was significantly enhanced in the presence of NO synthase (NOS) and cyclooxygenase (…
Properties and roles of BKCa channels in cultured cerebellar granule neuron: Experimental and simulation studies
2006
We studied the properties and roles of large-conductance calcium-sensitive potassium channels (BK"C"a) in cultured rat cerebellar granule neurons. In intact cells these channels had chord conductances of 130-200pS. The conductance, threshold for channel activation and the mean open time and open probability depend on the age of cells. In computer simulations the elimination of BK"C"a channel decreases the maximum and minimum peak values of an action potential, causes reduced hyperpolarization and increases firing frequency. The observed alterations may be linked to the complexity of granule neuron excitability during maturation and provide new insight into modeling the developmental changes…
Epilepsijas ārstēšana, medikamentu aprite un to ietekme uz koncentrēšanās spējām Bērnu klīniskajā universitātes slimnīcā
2017
Ievads: Latvijā netiek veidots reģistrs, kurā atspoguļotos epilepsijas ārstēšanas specifika 0 – 18 gadu vecuma grupā. Mērķis: noskaidrot epilepsijas ārstēšanas specifiku, pielietotās diagnostikas metodes, hospitalizēto, pirmreizēji diagnosticēto, medikamentozo terapiju uzsākušo pacientu skaitu; veikt zāļu apriti 2014. - 2016.gadam Bērnu Klīniskās Universitātes slimnīcas (BKUS) pacientiem vecuma grupā no 0 līdz 18 gadiem. Metode: BKUS arhīvā pieejamo bērnu slimības karšu analīze, intervija ar BKUS neirologu un pilotpētījums, izvēloties “Vizuālā mājiena meklēšanas”, “Perceptuālās saskaņošanas”, “Šternberga skenēšanas” testus. Rezultāti: 2014. – 2016. gadam BKUS saistībā ar epileptisku lēkmi h…
Postnatal overfeeding in rats leads to moderate overweight and to cardiometabolic and oxidative alterations in adulthood.
2011
In contrast to the masses of data on obesity, few data are available concerning the cardiometabolic and oxidative consequences of moderate overweight. The model of postnatal overfeeding (OF) induces an increase in body weight at weaning that remains during adult life. Litters of Wistar rats were either maintained at 12 pups (normal-fed group, NF), or reduced to 3 pups at birth in order to induce OF. At 6 months of age, metabolic parameters, circulating oxidative stress and aortic and coronary vasoreactivity were assessed. Cardiac susceptibility to ischemia-reperfusion injury was also evaluated ex vivo as were markers of cardiac remodeling. OF led to an increase in body weight at weaning (+5…
Cytomegalovirus and BK-Virus co-infection of a clinically non-functioning adrenal adenoma: innocent bystanders or new pathogenetic agents?
2006
We report a case of a 64-year-old woman who underwent left adrenalectomy with removal of a 8,5 cm clinically non-functioning adrenocortical adenoma and a 4-cm myelolipoma. Molecular testing for viral infection demonstrated the presence of cytomegalovirus (CMV) DNA sequences in the adrenal adenoma, but not in the myelolipoma (confirmed by immunohistochemistry). Moreover, the adrenal adenoma was also positive for parvovirus B19, and both adrenal tumor samples were positive for polyomavirus BK (BKV) and adenovirus DNA sequences. This is the first report of co-infection of an adrenocortical adenoma by CMV and BKV. The role of these viruses in adrenal tumorigenesis was postulated.
Genesis of the Lower Triassic bonebeds from Gogolin (S Poland): The impact of microbial mats on trapping of vertebrate remains
2017
Three bone-bearing horizons, consis ting of seven bone-bearing beds with fi sh and reptile remains, were recently discovered in the Uppermost Röt (Buntsandstein, Lower Tri assic) peritidal and shallow marine carbonates in the vi- cinity of Gogolin (S Poland). The aim of this study is to reco gnize the genesis and deposi tional environments of the bonebeds. Detailed fi eldwork, microfacies analysis, and SEM-EDS anal ysis reveal that the vertebrate remains occur to a great extent alongside evidence for former microbial activity. The reptile remains represent at least Dactylosaurus and Nothosaurus (Sauropterygia) genera, while the fi sh remains belong to the Chondrichthyes and Actinopterygii. …
Ilgtspējīgas attīstības sociālā dimensija un sociālā inovācija: tēžu krājums
2016
SUSTINNO
Ienākumu nevienlīdzība
2021
Bakalaura darba tēma ir „Ienākumu nevienlīdzība”. Darbā aprakstīti nevienlīdzīgas ekonomiskās situācijas cēloņi, veikta analīze Amerikas Savienoto valstu, Eiropas Savienības un Latvijas makroekonomiskajiem rādītājiem, veicot to ekonomiku salīdzinājumu. Bakalaura darba mērķis ir pamatojoties uz pieejamo informācijas bāzi izpētīt un analizēt ienākumu nevienlīdzību izmantojot makroekonomiskos rādītājus, kā arī veikt izpēti Amerikas, Eiropas un Latvijas ienākumu vienlīdzības sadalei. Veicot darbu secināju, ka Latvijai būtu īpaši jāfokusējas uz ekonomiskās nevienlīdzības novēršanu, ņemot vērā Latvijas pašreizējo pozīciju Eiropas Savienībā, kas parāda, ka Latvijā nevienlīdzība ir viena no augstāk…
Towards saturation of the electron-capture delayed fission probability: The new isotopes $^{240}Es$ and $^{236}Bk$
2016
Abstract The new neutron-deficient nuclei 240 Es and 236 Bk were synthesised at the gas-filled recoil separator RITU. They were identified by their radioactive decay chains starting from 240 Es produced in the fusion–evaporation reaction 209 Bi( 34 S,3n) 240 Es. Half-lives of 6 ( 2 ) s and 22 − 6 + 13 s were obtained for 240 Es and 236 Bk, respectively. Two groups of α particles with energies E α = 8.19 ( 3 ) MeV and 8.09 ( 3 ) MeV were unambiguously assigned to 240 Es. Electron-capture delayed fission branches with probabilities of 0.16 ( 6 ) and 0.04 ( 2 ) were measured for 240 Es and 236 Bk, respectively. These new data show a continuation of the exponential increase of ECDF probabilitie…