Search results for "Blastomas"

showing 3 items of 3 documents

Perfusion of surgical cavity wall enhancement in early post-treatment MR imaging may stratify the time-to-progression in glioblastoma

2017

Objective To determine if perfusion in surgical cavity wall enhancement (SCWE) obtained in early post-treatment MR imaging can stratify time-to-progression (TTP) in glioblastoma. Materials and methods This study enrolled 60 glioblastoma patients with more than 5-mm-thick SCWEs as detected on contrast-enhanced MR imaging after concurrent chemoradiation therapy. Two independent readers categorized the shape and perfusion state of SCWEs as nodular or non-nodular and as having positive or negative perfusion compared with the contralateral grey matter on arterial spin labeling (ASL). The perfusion fraction on ASL within the contrast-enhancing lesion was calculated. The independent predictability…

MaleCentral Nervous Systemlcsh:MedicineContrast MediaKaplan-Meier EstimatePathology and Laboratory MedicineNervous SystemDiagnostic Radiology030218 nuclear medicine & medical imaging0302 clinical medicineFunctional Magnetic Resonance ImagingMedicine and Health SciencesBlastomasMedicinelcsh:ScienceNeurological TumorsBrain MappingMultidisciplinarymedicine.diagnostic_testBrain NeoplasmsRadiology and ImagingChemoradiotherapyCombined Modality TherapyMagnetic Resonance ImagingDacarbazinePerfusionmedicine.anatomical_structureOncologyNeurology030220 oncology & carcinogenesisDisease ProgressionFemaleAnatomymedicine.symptomPerfusionResearch Articlemedicine.drugImaging TechniquesSurgical and Invasive Medical ProceduresNeuroimagingGrey matterResearch and Analysis MethodsLesion03 medical and health sciencesSigns and SymptomsText miningDiagnostic MedicineArterial Spin LabellingImage Interpretation Computer-AssistedTemozolomideHumansAgedTemozolomideSurgical Resectionbusiness.industryProportional hazards modellcsh:RCancers and NeoplasmsBiology and Life SciencesMagnetic resonance imagingmedicine.diseaseLesionslcsh:QSpin LabelsGlioblastomabusinessNuclear medicineGlioblastoma MultiformeNeuroscienceGlioblastomaPLOS ONE
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Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs

2017

Background Mismatch repair proteins (MMRPs) are a group of nuclear enzymes that participate in the repair of base mismatches that occur during DNA replication in all proliferating cells. The most studied MMRPs are hMSH2 and hMLH1, which are known to be highly expressed in normal tissues. A loss of MMRPs leads to the accumulation of DNA replication errors in proliferating cells. Ki-67 is a biomarker regarded to be the gold-standard tool for determining cell proliferation by immunohistochemical methods. The aim of this study was to investigate the immunohistochemical expression of hMLH1, hMSH2 and Ki-67 proteins in ameloblastomas and tooth germs, to contribute to the understanding of the deve…

congenital hereditary and neonatal diseases and abnormalitiesPathologymedicine.medical_specialtyhMSH2hMLH1Ameloblastoma03 medical and health sciencesTooth germsGERMEN DENTARIO0302 clinical medicinemedicineHumansHOMOLOGO 1 DE LA PROTEINA MutL (1)AmeloblastomaGeneral DentistryTooth GermsOral Medicine and PathologyAmeloblastomasbiologyCell growthResearchDNA replicationTooth Germnutritional and metabolic diseases030206 dentistry:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseImmunohistochemistryJaw NeoplasmsANTIGENO Ki-67PROTEINA 2 HOMOLOGA a MutS (1)digestive system diseasesKi-67 AntigenMutS Homolog 2 ProteinAMELOBLASTOMAOtorhinolaryngology030220 oncology & carcinogenesisKi-67UNESCO::CIENCIAS MÉDICASbiology.proteinKi-67Biomarker (medicine)ImmunohistochemistrySurgeryDNA mismatch repairMutL Protein Homolog 1Medicina Oral Patología Oral y Cirugia Bucal
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Comparison of the value of PCNA and Ki-67 as markers of cell proliferation in ameloblastic tumors

2012

Objectives: The aim of this study was to compare among PCNAand Ki-67 as the most reliable immunohisto chemical marker for evaluating cell proliferation in ameloblastic tumors. Study Design: Observational, retrospective, and descriptive study of a large series of ameloblastic tumors, com- D esign: Observational, retrospective, and descriptive study of a large series of ameloblastic tumors, com- esign: Observational, retrospective, and descriptive study of a large series of ameloblastic tumors, com posed of 161 ameloblastomas and four ameloblastic carcinomas, to determine and compare PCNA and Ki-67 expression using immunohistochemistry techniques. Results: When analyzing Ki-67 positivity, the…

Pathologymedicine.medical_specialtyCARCINOMADesmoplastic ameloblastomagovernment.form_of_governmentOdontologíaAmeloblastomaANTIGENO NUCLEAR DE CELULA EN PROLIFERACIONChemical markerCell proliferation markersstomatognathic systemProliferating Cell Nuclear AntigenProliferation ratemedicinePCNAHumansGeneral DentistryCell ProliferationRetrospective StudiesAmeloblastomasOral Medicine and PathologybiologyCell growthbusiness.industry:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludANTIGENO Ki-67Proliferating cell nuclear antigenAmeloblastic carcinomaKi-67 AntigenAMELOBLASTOMAOtorhinolaryngologyKi-67UNESCO::CIENCIAS MÉDICASbiology.proteingovernmentKi-67ImmunohistochemistryResearch-ArticleMouth NeoplasmsSurgerybusinessBiomarkersAmeloblastic carcinoma
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