Search results for "Blindness"

showing 10 items of 85 documents

The role of arginine-vasopressin for pineal melatonin synthesis in the rat: involvement of vasopressinergic receptors.

1991

Abstract The endogenously synthesized nonapeptide arginine vasopressin (AVP) is thought to be involved in transduction of photic information to the pineal gland. The enhancement of circulating AVP leads to a suppression of the nocturnal melatonin surge the mechanisms of which are unknown so far. We therefore studied the effect of dDAVP, an AVP analog with antidiuretic but without vasopressor activity, on pineal melatonin synthesis in Sprague-Dawley and AVP-deficient Brattleboro rats. The nocturnal intra-arterial application of dDAVP mimicked the inhibitory effect of AVP on the activity of the rate-limiting enzyme for pineal melatonin synthesis, N-acetyltransferase (NAT), in both rat strains…

Maleendocrine systemmedicine.medical_specialtyVasopressinReceptors VasopressinArylamine N-AcetyltransferaseBlindnessPineal GlandMelatoninPineal glandInternal medicinemedicineAnimalsDeamino Arginine VasopressinCircadian rhythmReceptorMelatoninReceptors Angiotensinbiologyurogenital systemSuprachiasmatic nucleusGeneral NeuroscienceRats BrattleboroRats Inbred Strainsbiology.organism_classificationBrattleboro ratRatsArginine VasopressinEndocrinologymedicine.anatomical_structurenervous systemInjections Intra-Arterialhormones hormone substitutes and hormone antagonistsEndocrine glandmedicine.drugNeuroscience letters
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Neuromuscular function and balance of prepubertal and pubertal blind and sighted boys

2006

Aim: To compare the neuromuscular function and balance of blind prepuberty- and puberty-aged boys to those with normal sight. Methods: Thirty-three prepubertal (aged 9–13 y) and pubertal (aged 15–18 y) blind and sighted boys were tested for muscle mass thickness, electromyography and maximal isometric strength, dynamic explosive actions, and balance. Results: There was no difference in the muscle mass thickness, maximal strength or vertical jump between the blind and sighted boys. However, fitness-ball throwing and five-jump distances were significantly shorter in both blind groups compared to the sighted groups. One-leg stance of the prepuberty-aged sighted boys was 109 (67) s and in blind…

Malemedicine.medical_specialtyAdolescentgenetic structuresPhysical fitnessBlindsightIsometric exerciseElectromyographyAudiologyBlindnessVertical jumpPrepubertymedicineHumansMuscle StrengthChildMuscle SkeletalPostural BalanceBalance (ability)medicine.diagnostic_testElectromyographybusiness.industryGeneral Medicineeye diseasesSurgeryCross-Sectional StudiesPhysical FitnessPediatrics Perinatology and Child HealthBody CompositionbusinessThrowingActa Paediatrica
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Branch retinal vein occlusion associated with the 20210 G-to-A prothrombin variant.

2000

Purpose To describe a case of branch retinal vein occlusion (BRVO) in a patient who tested positive for the 20210 A allele of the prothrombin (PT) gene. Methods A 48-year-old man had visual loss in the right eye secondary to BRVO confirmed by ophthalmoscopy and fluorescein angiography. His medical history was not remarkable for common risk factors for retinal occlusive diseases. Results Laboratory tests for hypercoagulability were positive for PT 20210 A variant. The patient's family tested negative for the PT variant. Conclusions Laboratory tests for coagulopathy, including the PT 20210 A variant, should be added to the examination of patients with central or BRVO, especially if most commo…

Malemedicine.medical_specialtyEye diseaseVisual AcuityBlindnessOphthalmoscopy03 medical and health scienceschemistry.chemical_compound0302 clinical medicineOphthalmologyRetinal Vein OcclusionCoagulopathyMedicineHumansPoint MutationFluorescein AngiographyClotting factormedicine.diagnostic_testbusiness.industryGenetic VariationRetinalGeneral MedicineMiddle Agedmedicine.diseaseFluorescein angiographyThrombosisSurgeryOphthalmologychemistry030221 ophthalmology & optometryBranch retinal vein occlusionProthrombinbusiness030217 neurology & neurosurgeryEuropean journal of ophthalmology
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Drug‐refractory myasthenia gravis: Clinical characteristics, treatments, and outcome

2022

[Objective] To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment.

Maleprogressive multifocal leukoencepdiarrheacholinergic receptorplasma exchangemiddle agedadultimmunologic factornauseaanemiahypertrichosisageddrug withdrawaldiabetes mellitusdisease severityTRIALsafetycorticosteroidhypertensionImmunologyMiastenia gravismethotrexateArticlebulbar paralysispancytopeniaMuscular DiseasescompulsionMyasthenia Gravischolinesterase inhibitorcross-sectional studyHumansImmunologic FactorshumanRITUXIMABarthralgiaNeurologíaMalalties muscularsAgedRetrospective Studiesmyasthenia gravisleukopeniaabdominal painDrug testingmajor clinical studyCross-Sectional StudiesDrug side effectscyclophosphamideobservational studyNeurology (clinical)immunoglobulinFEATURESefficacyclinical outcomeelectrophysiological procedurescomputer assisted tomographyDOUBLE-BLINDTratamiento médicorituximabOutcome Assessment Health CareImmunologiamuscle specific tyrosine kinaseRegistriestacrolimusazathioprineMedicamentoGeneral Neurosciencenephrotoxicitygeneral condition deteriorationhyperplasiatrialMiddle Agedliver toxicitydrug toxicityunclassified drugfemaleEfectes secundaris dels medicamentsSAFETYFemaledouble-blindheadacheblindnessAdultAssaigs clínics de medicamentsmalefeaturesfollow uppneumoniacyclosporinemycophenolate mofetilprotein tyrosine kinaseimmunosuppressive agentallergyalopeciaEFFICACYclinical featureosteopeniaSpainprednisonehyperglycemiaautoantibodyFollow-Up Studies
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Microaneurysms detection with the radon cliff operator in retinal fundus images

2010

ABSTRACT Diabetic Retinopathy (DR) is one of the leading causes of blindness in the industrialized world. Early detection is thekey in providing effective treatment. However, the current number of trained eye care specialists is inadequate to screenthe increasing number of diabetic patients. In recent years, automated and semi-automated systems to detect DR withcolor fundus images have been developedwith encouraging,but not fully satisfactory results. In this study we present theinitial results of a new techniquefor the detection and localization of microaneurysms,an early sign of DR. The algorithmis based on three steps: candidates selection, the actual microaneurysms detection and a Þnal …

MicroaneurysmRetinaBlindnessComputer sciencebusiness.industryImage processingRetinalDiabetic retinopathyFundus (eye)medicine.diseasechemistry.chemical_compoundmedicine.anatomical_structurechemistrymedicineComputer visionSegmentationArtificial intelligencebusinessRetinopathySPIE Proceedings
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The temple of visual culture and people with visual impairments: museum accessibility as mental colonization

Accessibility raises political and cultural questions about inclusion and inclusive practices. Museums worldwide now offer multisensory access programs for people with visual impairments, which could appear as an actual implementation of the purpose of the Convention on the Rights of Persons with Disabilities of full inclusion and respect of disabled pleople as part of human diversity. However, by focusing on touch, they often passively exclude people with visual impairments because of their foundation in ocularcentric assumptions about knowledge, misconceptions about visual impairments, and aesthetic and epistemological potential of other 'senses'. Differently, approaches deeply aware of s…

Museum accessibility blindness ocularnormativity mental colonization
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Anger is superior to happiness in change blindness as indicated by behavioral and electrophysiological measures

2012

Neuropsychology and Physiological PsychologyPhysiology (medical)General Neurosciencemedia_common.quotation_subjectChange blindnessHappinessAngerPsychologymedia_commonDevelopmental psychologyInternational Journal of Psychophysiology
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Dialogue in the Dark: Shedding Light on the Development of Social Enterprises in China

2015

International audience; The application of for-profit business practices to nonprofit organizations, social enterprises are a way for nonprofit organizations to find funding in a time of rising costs, falling donations, and increased competition from for-profit businesses in the social sector. Although well established in the mature economies of the West, these enterprises are a novelty in the emerging economies of Asia and in the transitional economies of the former communist world. The experiences of Dialogue in the Dark, a social enterprise concerned with the problems associated with blindness, highlight the unique challenges that social enterprises face in China and offer lessons for en…

Organizational Behavior and Human Resource ManagementChinaBlindness1. No povertyNoveltyFace (sociological concept)Social Enterprisesmedicine.diseaseBlindness[SHS.ECO]Humanities and Social Sciences/Economics and Finance[SHS]Humanities and Social SciencesCompetition (economics)Market economyNon-profit entrepreneurshipmedicineEconomics[SHS.GESTION]Humanities and Social Sciences/Business administrationBusiness and International ManagementEconomic systemEmerging marketsChina[SHS.ECO] Humanities and Social Sciences/Economics and Finance[SHS.GESTION] Humanities and Social Sciences/Business administrationCommunismSocial economy
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CEGUERA AL PATROCINADOR: APLICACIÓN A CARTELES DE EVENTOS DEPORTIVOS

2018

Advertising posters in sports sponsorship are versatile marketing tools with significant media impact and high visibility. However, the academic literature on the impact of advertising posters in this field is scarce. The purpose of this research is to measure the spontaneous recall of and attention toward busi­ness brands sponsoring sports events while assessing their location and congruence level. The sample was segmented according to gender. The experiment involved 12 stimuli related to three sporting disci­plines corroborating the issue of media blindness with respect to advertising posters. Consistent with the placement theory, we found that the position of the sponsoring brand affecte…

Organizational Behavior and Human Resource ManagementInformation Systems and ManagementStrategy and ManagementManagement Science and Operations ResearchPatrocinioImage transferManagement of Technology and Innovation0502 economics and businessmedicineBusiness and International Managementseguimiento ocularMedia impactMarketingBlindnessRecall05 social sciencescartel deportivoAdvertisingmedicine.diseaseemplazamientoIndustrial relationsBusiness Management and Accounting (miscellaneous)050211 marketingrecuerdoPsychology050212 sport leisure & tourism
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Norrie gene product is necessary for regression of hyaloid vessels.

2004

To investigate the nature and origin of the vitreous membranes in mice with knock-out of the Norrie gene product (ND mice).Eighty-two eyes of ND mice of different age groups (postnatal day [P]0-13 months) and 95 age-matched wild-type control mice were investigated. In vitreoretinal wholemounts and in sagittal sections, vessels and free cells were visualized by labeling for lectin. In addition, staining with a marker for macrophages (F4/80) and collagen XVIII/endostatin known to be involved in regression of hyaloid vessels was performed for light and electron microscopic investigations. Endostatin expression was confirmed by Western blot analysis.Wild-type controls showed the typical pattern…

Pathologymedicine.medical_specialtygenetic structuresAngiogenesisBlotting WesternNerve Tissue ProteinsBiologyRetinal NeovascularizationBlindnessGene productchemistry.chemical_compoundMiceVasculogenesismedicineAnimalsEye AbnormalitiesEye ProteinsMicroscopy ImmunoelectronMice KnockoutMembranesRetinal DegenerationRetinal VesselsRetinalGenetic Diseases X-LinkedAnatomyAntigens Differentiationeye diseasesEndostatinsVitreous Bodymedicine.anatomical_structurechemistryCirculatory systemcardiovascular systemsense organsEndostatinBlood vesselInvestigative ophthalmologyvisual science
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