Search results for "Blocking"

Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocking Antibody against PD-1+ Chemoresistant Lung Cancer Cells

2022

Abstract Purpose: Antibodies against the lymphocyte PD-1 (aPD-1) receptor are cornerstone agents for advanced non–small cell lung cancer (NSCLC), based on their ability to restore the exhausted antitumor immune response. Our study reports a novel, lymphocyte-independent, therapeutic activity of aPD-1 against NSCLC, blocking the tumor-intrinsic PD-1 receptors on chemoresistant cells. Experimental Design: PD-1 in NSCLC cells was explored in vitro at baseline, including stem-like pneumospheres, and following treatment with cisplatin both at transcriptional and protein levels. PD-1 signaling and RNA sequencing were assessed. The lymphocyte-independent antitumor activity of aPD-1 was explored in…

Call admission control scheme using borrowable guard channels and prioritizing fresh calls retrials in small cell networks

2014

International audience; Recent trends in mobile cellular networks turn towards deployment of Small Cell Networks (SCNs), where, the cell size gets smaller, and thus the number of subscribers served in a cell will be relatively smaller, such that traffic models with a finite source of subscribers should be considered. Smaller cells cause the mobile subscribers to cross several cells during an ongoing conversation resulting in frequent handovers. Most of works dealing with Call Admission Control (CAC) problems based on guard channels scheme in cellular mobile networks consider models without retrials (reapeted calls phenomenon). However, almost all existing works which take into account retri…

Digital Device Usage Time and Ocular Symptoms during COVID-19 Pandemic

2021

Bakalaura darbs ir uzrakstīts angļu valodā uz 25 lappusēm. Tas satur 10 attēlus, 6 tabulas un 22 atsauces uz literatūras avotiem. Šī pētījuma galvenais mērķis bija novērtēt kā digitālo ierīču lietošanas izmaiņas ikdienā pirms Covid-19 pandēmijas un pandēmijas laikā Itālijā ietekmē acu nogurumu. Digitālo ierīču ietekme uz acīm tika novērtēta, apkopojot pētījuma dalībnieku atbildes uz anketas jautājumiem. Digitālo ierīču izmantošana mūsdienās ir plaši izplatīta, tās ir jāizmanto, bet ievērojot nepieciešamos piesardzības pasākumus, lai neradītu traucējumus redzes un psihiskajā sistēmās.

Disponibilidad de productos y servicios en línea en el mercado único digital

2021

En el sector del comercio electrónico de la UE, los consumidores han visto en multitud de ocasiones obstaculizadas las transacciones en línea cuando intentaban adquirir el producto o contratar el servicio de un comerciante situado en otro Estado miembro debido a la técnica del bloqueo geográfico. Conocedor de ello, el legislador vela por la represión de las prácticas discriminatorias en las transacciones comerciales en la UE; esto es, por que no se den situaciones en las que no exista una justificación objetiva para el trato diferente por razón de la nacionalidad, de la residencia o del lugar de establecimiento (incluidos criterios indirectos como la dirección IP o los datos de pago) del cl…

Ojituksen ja ennallistamisen aiheuttamat muutokset kasvilajistossa ja –yhteisöissä

2013

Verkostonäkökulma ennallistamiskohteiden valinnassa

2013

Verkostonäkökulma korostuu vahvasti luonnonsuojelun suunnittelussa Suomessa ja maailmalla. Suojelualueita ei voi nähdä yksittäisinä eristyneinä alueina, vaan luonnonsuojelualueiden verkosto ja koko ympäröivä maisema ylläpitävät yhdessä tietyn alueen eliölajistoa. Parhaiden alueiden kytkeytyvyyden varmistamista ja verkostojen ylläpitämistä on myös ehdotettu ratkaisuksi biodiversiteetin säilyttämiselle, kun ilmastonmuutos pakottaa lajeja siirtymään uusille asuinalueille. Verkostonäkökulma kannattaa huomioida myös ennallistamiskohteiden valinnassa – mikä ei kuitenkaan ole yksiselitteistä ja helppoa. nonPeerReviewed

Ekosysteemin ennallistamisen ja luonnonhoidon ekologia

2013

Decomposition of nitrous oxide upon nickel oxide-magnesium oxide solid solutions

1966

The decomposition of N 2 O has been studied over MgO catalysts, doped with NiO and NiO + Li 2 O from 1 to 10% (atomic). For pure MgO, activity is low, but is enhanced by addition of Ni 2+ ions. The apparent activation energy is reduced from 35 kcal/mole for pure MgO, to about 18 kcal/mole. Oxygen acts as a poison, and it is chemisorbed on the catalyst. The presence of lithium greatly increases the apparent activation energy. The results are interpreted in terms of oxygen chemisorption and of its influence on the course of the reaction.

Easy Method for the Transformation of Levulinic Acid into Gamma-Valerolactone Using a Nickel Catalyst Derived from Nanocasted Nickel Oxide

2019

Different nickel catalysts have been tested for the transformation of levulinic acid into &gamma

Surface interaction of Ni/Mo oxides on ultrastable Y zeolites

1986

The interactions of NiO, MoO 3 and their mixtures with the acid surface of an H-Y ultrastable zeolite have been studied on a series of samples. These samples were prepared by impregnation, calcination and reduction, (if necessary), of Ni and Mo salts, on an H-Y ultrastable zeolite (HYUS). By using i.r. spectroscopy and X-ray diffraction techniques it has been observed that MoO 3 interacts with most of the hydroxyl groups while NiO interacts only with those appearing at 3640 and 3550 cm −1 . In the samples containing both oxides a strong interaction between them is shown, while the acidity of the original HYUS is partially regenerated. The influence of the order of impregnation on the final …