Search results for "Blood group antigens"
showing 10 items of 36 documents
Studies on serum groups in the Kumaon region, India
1970
A total of 469 individuals belonging to 4 endogamous groups (Brahamins, Rajputs, Doms and Tharus) from the Kumaon region (North India) were tested for Hp, Gc, Gm and Inv systems.
Associations between leprosy and serum protein groups
1970
Serum protein group typings were done on a sample of n=173 adult healthy Negroes from the Macua tribe in Mozambique and on n=129 leprous individuals from the same tribe. Unfortunately, the type of leprosy is not known. Whilst between leprosy and haptoglobins, transferrins and Pi proteins no associations could be observed, statistically significant associations between leprosy and ceruloplasmin resp. β2 I were found. It is pointed out that these associations should be confirmed by further research on other populations and with respect to type and process of leprosy, until biological and population genetical interpretations will be possible.
Blood group related antigens in ocular cicatricial pemphigoid
2004
Aim: To study the MUC5AC and the blood group related antigen expression in ocular cicatricial pemphigoid (OCP) according to the distribution of Lewis and secretor phenotypes in OCP patients compared to normal subjects. Methods: Immunostaining was performed on conjunctival biopsy specimens from 22 consecutive patients suffering from OCP, using monoclonal antibodies (Mabs) directed against the peptidic core MUC5AC mucin (anti-M1/MUC5AC Mabs) and against the saccharide moieties (anti-blood group related antigens). These latter included anti-Lea, anti-Leb, anti-sialyl Lea, and H type 2 Mabs, which immunoreact with Lewis positive and non-secretor (Lea), Lewis positive and secretor (Leb), Lewis p…
Spacer-separated sialyl LewisX cyclopeptide conjugates as potential E-selectin ligands.
2006
Completely protected sialyl LewisX azide was synthesized from a neolactosamine azide precursor carrying a 3-O-allyloxycarbonyl group as the temporary protecting group. After its Pd(0)-catalyzed deprotection and stereoselective alpha-fucosylation, the obtained LewisX azide was subjected to O-deacetylation in the galactose unit and subsequent regio- and stereoselective sialylation. Reduction of the anomeric azido group afforded the sialyl LewisX amine building block. Two molecules of this tetrasaccharide ligand were conjugated to a preformed cyclooctapeptide containing two equidistant l-asparagine units equipped with carboxy-terminated tetraethyleneglycol side chains to give, after deprotecti…
Nachweis der Faktoren Gm (1,2,4,5,21) und In V(1) in menschlichen Sekreten: Speichel, Schwei�, Nasensekret und Sperma
1977
Im Sperma sind bei genugend Substrat Gm- und InV-Faktoren nachweisbar. An Uberlagerungen durch Nasen- oder Scheidensekret mus gedacht werden. Dagegen wirkt sich Schweis als Verunreinigung nicht storend aus. Im Speichel konnen keine Gm-, wohl aber InV-Merkmale festgestellt werden. Die Gummierung der Briefmarken reagiert unspezifisch mit InV-Antiseren und kommt daher als Fehlerquelle in Betracht. Der Beweiswert von Gm- und InV-Befunden bei Spurenuntersuchungen ergibt sich aus den Phanotyp-Frequenzen, die im Serum von 400 nichtverwandten Personen festgestellt wurden.
A NEW PCR-BASED TYPING OF THE RODGERS AND CHIDO ANTIGENIC DETERMINANTS OF THE FOURTH COMPONENT OF HUMAN COMPLEMEMT
1994
The Rodgers (Rg) and Chido (Ch) blood groups are antigenic determinants of the fourth component of human complement C4. They are associated with the two isotypes of C4, C4A and C4B, respectively. They serve as markers to distinguish C4A from C4B as well as for the definition of subtypes of common and rare allotypes. As an alternative to the serological typing method using human alloantisera, a PCR typing procedure with sequence-specific primers (PCR-SSP) was designed. The method was tested on selected DNA samples from individuals with well-defined C4 allotypes. No false-positive or false-negative typing results were obtained and all the determinant combinations could be distinguished. The P…
Untersuchungen zur Populationsgenetik von Island, insbesondere der Region Dalas�sla
1967
The authors report the results of a population genetic survey of the Dalasýsla region (West-Iceland). Our sample size includes n=193 male and female individuals of different age. These individuals are partly related. The following blood and serum groups were determined: ABO, MNS, Rh, P; Hp, Gc, Gm, InV, and Lp. In all these systems observed and expected phenotype frequencies are found to be in good agreement. The following gene frequencies turned out: p1A=.0888, p2A=.0456, qB=.0293, rO=.8363; pMS=.2256, pMs=.4474, pNS=.0540, pNs=.2730; cde=.4123, Cde=.0966, cDe=.0338, CDe=.2984, cDE=.1589; pP=.4833; Hp1=.5157, Hp2=.4843; Gc1=.7340, Gc2=.2660; Gm1=.1846, Gm1,2=.1444, Gm12=.6710. The frequenc…
Highly regioselective synthesis of a 3-O-sulfonated arabino Lewisa asparagine building block suitable for glycopeptide synthesis
2006
Using the stannylene method, the trisaccharide 2-acetamido-3-O-[6-O-benzyl-beta-D-galactopyranosyl]-4-O-[2,3,4-tri-O-benzyl-beta-D-arabinopyranosyl]-6-O-benzyl-2-deoxy-beta-D-glucopyranosyl azide was regioselectively sulfonated and, after reduction of the anomeric azide, coupled to Fmoc alpha-allyl aspartate. After Pd(0)-catalyzed deallylation, the sulfatyl Lewis(a) asparagine building block was obtained, suitable for solid-phase glycopeptide synthesis applying the fluoride labile PTMSEL linker system.
Synthesis of tumor-associated glycopeptide antigens.
2002
Carbohydrates and peptides linked together in glycoproteins constitute important components of the molecular communication between cells in multicellular organisms. Cell morphogenesis and tumorigenesis are accompanied by changes in the glycoprotein profiles of the outer cell membranes. Glycopeptide fragments of glycoproteins that have altered structures in tumor cells are of interest as tumor-associated antigens for the distinction between normal cells and tumor cells. In contrast to glycoproteins isolated from biological sources, synthetic glycopeptides are obtained in pure form and exactly specified structures. The methods developed for the synthesis of glycopeptides with tumor-associated…
Study of some serum group systems in the Mahishyas and the Muslims in 24-Parganas district, West Bengal
1974
A survey of serum Pi, Cp, Hp and Tf was carried out in 104 Bengali Hindu Mahishya and 123 Bengali Muslim of West Bengal, India.