Search results for "Blood"

showing 10 items of 5199 documents

Der gegenwärtige Stand der Blutfiltration - Grundlagen und klinische Bedeutung von Leukozytendepletions- und Mikroaggregatfiltern bei der Bluttransfu…

1993

In this review the role of the latest generation of leukodepletion blood filters and the adverse reaction of leukocytes i.e. alloimmunisation, immunosuppression, nonhaemolytic febrile transfusion reaction, platelet refractoriness, transmission of infectious agents are described and discussed. Leukocyte-poor blood component is indicated for patients with a history of nonhaemolytic febrile transfusion reaction, in avoiding alloimmunisation in patients waiting for transplantation or platelet refractoriness and in preventing CMV-infection. In the review the role of microaggregate filters in transfusion complications, namely, nonhaemolytic febrile transfusion reaction, thrombocytopenia, adult re…

ARDSBlood transfusionRespiratory distressbusiness.industrymedicine.medical_treatmentImmunosuppressionGeneral MedicineCritical Care and Intensive Care Medicinemedicine.diseaseBlood cellTransplantationAnesthesiology and Pain Medicinemedicine.anatomical_structureBlood productIntensive careImmunologyEmergency MedicinemedicinebusinessAINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie
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Coronavirus Disease 2019–Associated Coagulopathy

2021

Patients with the severe form of coronavirus disease 2019 (COVID-19) have been frequently found to suffer from both arterial and venous thrombotic events due to the perpetuation of a hypercoagulable state. This phenomenon, termed COVID-19-associated coagulopathy (CC), is now considered a major component of the pathophysiology of this novel infectious disease, leading to widespread thrombosis. While at first, the vascular insults may be limited to the pulmonary microvasculature, as the disease progresses, systemic involvement occurs, culminating in distant organ thrombosis and multi-organ dysfunction syndrome. In this review article, we discuss recent insights into the pathophysiologic mecha…

ARDSPAI-1 Plasminogen Activator Inhibitor 1VTE venous thromboembolismDiseaseReview030204 cardiovascular system & hematologyCoronavirus Disease 20190302 clinical medicineCoagulopathy030212 general & internal medicineDIC disseminated intravascular coagulationDisseminated intravascular coagulationCOVID-19 Coronavirus disease 2019DVT deep vein thrombosisGeneral MedicineBlood Coagulation DisordersThrombosisICU intensive care unitTMA thrombotic microangiopathyDisease ProgressionCoronavirus Disease 2019 COVID-19 CoagulopathyVWF von Willebrand factormedicine.medical_specialtyThrombotic microangiopathyACE2 angiotensin-converting enzyme 2SARS-CoV-2 severe acute respiratory syndrome coronavirus 203 medical and health sciencesmedicineCoagulopathyHumansIntensive care medicineLY30 lysis at 30 minutesARDS acute respiratory distress syndromeHemostasisNO nitric oxideCoagulationbusiness.industrySARS-CoV-2COVID-19Thrombosismedicine.diseasetPA tissue plasminogen activatorReview articleIL interleukinCoronavirusVascular DisorderPE pulmonary embolismTF tissue factorbusinessCC COVID-associated coagulopathyMayo Clinic Proceedings
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Quantification of atelectatic lung volumes in two different porcine models of ARDS.

2006

BACKGROUND: Cyclic recruitment during mechanical ventilation contributes to ventilator associated lung injury. Two different pathomechanisms in acute respiratory distress syndrome (ARDS) are currently discussed: alveolar collapse vs persistent flooding of small airways and alveoli. We compare two different ARDS animal models by computed tomography (CT) to describe different recruitment and derecruitment mechanisms at different airway pressures: (i) lavage-ARDS, favouring alveolar collapse by surfactant depletion; and (ii) oleic acid ARDS, favouring alveolar flooding by capillary leakage. METHODS: In 12 pigs [25 (1) kg], ARDS was randomly induced, either by saline lung lavage or oleic acid (…

ARDSPulmonary AtelectasisVentilator-associated lung injurySwinemedicine.medical_treatmentBlood PressureLung injurySodium ChlorideImage Processing Computer-AssistedMedicineAnimalsLung volumesContinuous positive airway pressureMechanical ventilationRespiratory Distress SyndromeLungContinuous Positive Airway Pressurebusiness.industryPulmonary Gas ExchangeRespiratory diseaserespiratory systemmedicine.diseaserespiratory tract diseasesPulmonary AlveoliDisease Models AnimalAnesthesiology and Pain Medicinemedicine.anatomical_structureAnesthesiabusinessLung Volume MeasurementsTomography X-Ray ComputedOleic AcidBritish journal of anaesthesia
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Random allogeneic blood transfusion in pigs: characterisation of a novel experimental model.

2019

BackgroundOrgan cross-talk describes interactions between a primary affected organ and a secondarily injured remote organ, particularly in lung-brain interactions. A common theory is the systemic distribution of inflammatory mediators that are released by the affected organ and transferred through the bloodstream. The present study characterises the baseline immunogenic effects of a novel experimental model of random allogeneic blood transfusion in pigs designed to analyse the role of the bloodstream in organ cross-talk.MethodsAfter approval of the State and Institutional Animal Care Committee, 20 anesthetized pig were randomized in a donor and an acceptor (eachn = 8): the acceptor animals …

ARDSmedicine.medical_specialtyBlood transfusionEmergency and Critical Caremedicine.medical_treatmentSurgery and Surgical Specialtieslcsh:MedicineInflammation030204 cardiovascular system & hematologyGeneral Biochemistry Genetics and Molecular BiologyPulmonary function testing03 medical and health sciences0302 clinical medicinemedicineExperimental modelAdverse effectRespiratory MedicineCrosstalkLungAnesthesiology and Pain ManagementWhole bloodInflammationLungbusiness.industryTransfusionGeneral Neurosciencelcsh:RBrain030208 emergency & critical care medicineHematologyGeneral Medicinemedicine.diseaseBloodPig modellmedicine.anatomical_structureAnesthesiaARDSHistopathologymedicine.symptomGeneral Agricultural and Biological SciencesbusinessPeerJ
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Safety and immunomodulatory effects of three probiotic strains isolated from the feces of breast-fed infants in healthy adults: SETOPROB study.

2013

We previously described the isolation and characterization of three probiotic strains from the feces of exclusively breast-fed newborn infants: Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036. These strains were shown to adhere to intestinal mucus in vitro, to be sensitive to antibiotics and to resist biliary salts and low pH. In the present study, a multicenter, randomized, double-blind, placebo-controlled trial with 100 healthy volunteers in three Spanish cities was carried out to evaluate the tolerance, safety, gut colonization and immunomodulatory effects of these three probiotics. Volunteers underwent a 15-day washout perio…

ARN Bacterianoved/biology.organism_classification_rank.speciesPhysiologylcsh:Medicine:Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment::Ecosystem::Biodiversity::Biota::Microbiota [Medical Subject Headings]law.inventionFecesProbioticAntibioticslawLactobacillus:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Child Nutritional Physiological Phenomena::Infant Nutritional Physiological Phenomena::Breast Feeding [Medical Subject Headings]lcsh:Science:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::RNA::RNA Bacterial [Medical Subject Headings]BifidobacteriumMultidisciplinaryBifidobacterium brevebiologyLacticaseibacillus rhamnosusMicrobiotaHibridación in SituInterleukin-10:Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Lactobacillaceae::Lactobacillus [Medical Subject Headings]Breast FeedingBloodCytokinesFemaleResearch ArticleAdult:Anatomy::Fluids and Secretions::Feces [Medical Subject Headings]Lactobacillus paracasei:Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Clostridium::Clostridium difficile [Medical Subject Headings]Microbiology:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::Nucleic Acid Probes::Oligonucleotide Probes [Medical Subject Headings]Double-Blind MethodLactobacillus rhamnosusHumansImmunologic Factors:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Histocytological Preparation Techniques::Staining and Labeling::In Situ Hybridization [Medical Subject Headings]FecesSafety studiesved/biologyProbioticslcsh:RClostridium difficile:Organisms::Bacteria::Gram-Positive Bacteria::Actinobacteria::Bifidobacterium [Medical Subject Headings]biology.organism_classificationImmunoglobulin ALactobacilluslcsh:QInterleukin-4BifidobacteriumBreast feedingSondas de OligonucleótidosPLoS ONE
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Alkamides from Echinacea angustifolia Interact with P-Glycoprotein of Primary Brain Capillary Endothelial Cells Isolated from Porcine Brain Blood Ves…

2013

The blood-brain barrier prevents the passage of toxic compounds from blood circulation into brain tissue. Unfortunately, drugs for the treatment of neurodegenerative diseases, brain tumors, and other diseases also do not cross the blood-brain barrier. In the present investigation, we used isolated porcine brain capillary endothelial cells and a flow cytometric calcein-AM assay to analyze inhibition of P-glycoprotein, a major constituent of the blood-brain barrier. We tested 8 alkamides isolated from Echinacea angustifolia and found that four of them inhibited P-glycoprotein-mediated calcein transport in porcine brain capillary endothelial cells.

ATP Binding Cassette Transporter Subfamily BPolyunsaturated AlkamidesSwinePharmaceutical ScienceATP-binding cassette transporterCapillary endothelial cellsPharmacologyBlood–brain barrierEchinaceaAnalytical Chemistrychemistry.chemical_compoundDrug DiscoverymedicineAnimalsCells CulturedP-glycoproteinPharmacologyDose-Response Relationship DrugMolecular StructurebiologyEchinacea angustifoliaOrganic ChemistryBrainEndothelial CellsBiological TransportFlow CytometryFluoresceinsbiology.organism_classificationCalceinmedicine.anatomical_structureComplementary and alternative medicinechemistryBlood-Brain BarrierBlood circulationbiology.proteinMolecular MedicinePorcine brainPlanta Medica
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Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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Intraoperative transfusion practices in Europe

2016

PubMed: 26787795

AUSTRIAN BENCHMARKMaleBlood transfusionmedicine.medical_treatment610 Medizinanaemia anesthesia blood transfusion surgery transfusion trigger030204 cardiovascular system & hematologyGUIDELINESsurgeryCohort Studies0302 clinical medicine030202 anesthesiologyMedicine and Health SciencesMedicineProspective StudiesProspective cohort studyddc:610Research Support Non-U.S. Gov'tMiddle AgedHospitalsEuropeFemaleAllogeneic transfusionCohort studymedicine.medical_specialtyTransfusion rateObservational Studyanesthesiablood transfusionELECTIVE SURGERYClinical Practice03 medical and health sciencesJournal Articleanaemia ; anesthesia ; blood transfusion ; surgery ; transfusion triggerHumansBlood TransfusionElective surgeryCHLC ANSIntensive care medicineanaemiatransfusion triggerIntraoperative Carebusiness.industryPREOPERATIVE ANEMIAPATIENT BLOOD MANAGEMENTClinical trialAnesthesiology and Pain MedicineEmergency medicinebusinessPacked red blood cellsREQUIREMENTSBritish journal of anaesthesia
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Periscopes, chimneys, sandwich and VORTEC to facilitate abdominal and thoracoabdominal aortic aneurysm repair

2012

The VORTEC (VIABAHN open revascularization technique) and the chimney graft technique are tools with which to maintain or restore blood flow to the aortic branches and can be used intentionally or as a bailout procedure in open surgery or endovascular procedures. VORTEC is a stent graft-based vascular connection technique that achieves end-to-end anastomosis configuration; it is especially useful when the traditional suture technique proves (can be) cumbersome. It is also a speedy tool with virtually no blood flow interruption and no anastomotic bleeding, and patency rates compare favorably with sutured anastomosis. The chimney/periscope, as well as the sandwich graft technique (CHIMPES), i…

Abdominal aorta Thoracic aorta Aortic aneurysm Blood vessel prosthesis Endovascular procedures
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Hypotensive Hemostasis in Patients Presenting with Ruptured Aortic Aneurysm

2017

Hypotensive hemostasis in aortic rupture has been showed to be feasible and advantageous, especially in trauma patients. To date, there are no randomized studies on hypotensive hemostasis in patients with ruptured abdominal aortic aneurysm (rAAA), but observational studies indicate similar advantages when hypotensive hemostasis is used for endovascular aneurysm repair (EVAR) as in trauma patients. Actually, in EVAR for rAAA, a target systolic blood pressure of 90 mmHg or even lower is considered safe in conscious patients. Fluids should be administrated judiciously with the sole aim of maintaining adequate cardiac output and tissue oxygenation, whereas vasoactive pressors or dilatators may …

Abdominal compartment syndromebusiness.industrymedicine.medical_treatmentHypotensive; Hemostasis; Ruptured; Aortic AneurysmHemodynamics030208 emergency & critical care medicineRuptured Aortic Aneurysm030204 cardiovascular system & hematologyHypotensiveHemostasimedicine.diseaseEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareAbdominal aortic aneurysmRupturedAortic Aneurysm03 medical and health sciences0302 clinical medicineBlood pressureAnesthesiaHemostasiscardiovascular systemmedicinebusinessAortic rupture
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